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Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Q Zhang, P Bastard, Z Liu, J Le Pen, M Moncada-Velez, J Chen, M Ogishi, ... Science 370 (6515), 2020 | 2216 | 2020 |
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ... Science Immunology 6 (62), 2021 | 477 | 2021 |
Human genetic and immunological determinants of critical COVID-19 pneumonia Q Zhang, P Bastard, A Cobat, JL Casanova Nature, 1-15, 2022 | 250 | 2022 |
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine P Bastard, E Michailidis, HH Hoffmann, M Chbihi, T Le Voyer, J Rosain, ... Journal of Experimental Medicine 218 (4), 2021 | 157 | 2021 |
IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21–producing B helper CD8+ T cells R Yang, AR Masters, KA Fortner, DP Champagne, N Yanguas-Casás, ... Journal of Experimental Medicine 213 (11), 2281-2291, 2016 | 147 | 2016 |
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies J Manry, P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, ... Proceedings of the National Academy of Sciences 119 (21), 2022 | 142 | 2022 |
Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation Q Zhang, P Bastard, A Bolze, E Jouanguy, SY Zhang, CHG Effort, A Cobat, ... Med 1 (1), 14-20, 2020 | 142 | 2020 |
Mitochondrial Stat3, the Need for Design Thinking R Yang, M Rincon International Journal of Biological Sciences 12 (5), 532, 2016 | 126 | 2016 |
Inherited human IFN-γ deficiency underlies mycobacterial disease G Kerner, J Rosain, A Guérin, A Al-Khabaz, C Oleaga-Quintas, ... The Journal of clinical investigation 130 (6), 2020 | 115 | 2020 |
Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria R Yang, F Mele, L Worley, D Langlais, J Rosain, I Benhsaien, H Elarabi, ... Cell 183 (7), 1826-1847. e31, 2020 | 110 | 2020 |
Homozygosity for TYK2 P1104A underlies tuberculosis in about 1% of patients in a cohort of European ancestry G Kerner, N Ramirez-Alejo, Y Seeleuthner, R Yang, M Ogishi, A Cobat, ... Proceedings of the National Academy of Sciences 116 (21), 10430-10434, 2019 | 105 | 2019 |
Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function R Yang, D Lirussi, TM Thornton, DM Jelley-Gibbs, SA Diehl, LK Case, ... Elife 4, e06376, 2015 | 92 | 2015 |
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child M Ogishi, R Yang, C Aytekin, D Langlais, M Bourgey, T Khan, F Al Ali, ... Nature Medicine, 1-9, 2021 | 89 | 2021 |
RP105 protects against apoptosis in ischemia/reperfusion-induced myocardial damage in rats by suppressing TLR4-mediated signaling pathways J Yang, X Guo, J Yang, J Ding, S Li, R Yang, Z Fan, C Yang Cellular Physiology and Biochemistry 36 (6), 2137-2148, 2015 | 72 | 2015 |
Fine-Tuning of CD8+ T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus DP Champagne, KM Hatle, KA Fortner, A D’Alessandro, TM Thornton, ... Immunity 44 (6), 1299-1311, 2016 | 70 | 2016 |
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy V Béziat, F Rapaport, J Hu, M Titeux, MB des Claustres, M Bourgey, ... Cell, 2021 | 67 | 2021 |
Resveratrol pretreatment protects rat hearts from ischemia/reperfusion injury partly via a NALP3 inflammasome pathway W Dong, R Yang, J Yang, J Yang, J Ding, H Wu, J Zhang International journal of clinical and experimental pathology 8 (8), 8731, 2015 | 61 | 2015 |
Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease T Le Voyer, AL Neehus, R Yang, M Ogishi, J Rosain, F Alroqi, M Alshalan, ... Proceedings of the National Academy of Sciences 118 (15), 2021 | 60 | 2021 |
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells R Yang, DT Avery, KJL Jackson, M Ogishi, I Benhsaien, L Du, X Ye, J Han, ... Science Immunology 7 (73), eabq3277, 2022 | 44 | 2022 |