| Malignant astrocytic glioma: genetics, biology, and paths to treatment FB Furnari, T Fenton, RM Bachoo, A Mukasa, JM Stommel, A Stegh, ... Genes & development 21 (21), 2683-2710, 2007 | 2906 | 2007 |
| Telomere shortening and tumor formation by mouse cells lacking telomerase RNA MA Blasco, HW Lee, MP Hande, E Samper, PM Lansdorp, RA DePinho, ... Cell 91 (1), 25-34, 1997 | 2682 | 1997 |
| ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF TG Boulton, SH Nye, DJ Robbins, NY Ip, E Radzlejewska, ... Cell 65 (4), 663-675, 1991 | 2533 | 1991 |
| Hepatocellular carcinoma pathogenesis: from genes to environment PA Farazi, RA DePinho Nature Reviews Cancer 6 (9), 674-687, 2006 | 2458 | 2006 |
| The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy, RA DePinho, ... Science 310 (5754), 1642-1646, 2005 | 2360 | 2005 |
| The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress RJ Shaw, M Kosmatka, N Bardeesy, RL Hurley, LA Witters, RA DePinho, ... Proceedings of the National Academy of Sciences 101 (10), 3329-3335, 2004 | 2146 | 2004 |
| The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 J Pomerantz, N Schreiber-Agus, NJ Liégeois, A Silverman, L Alland, ... Cell 92 (6), 713-723, 1998 | 2016 | 1998 |
| Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ... Cell 149 (3), 656-670, 2012 | 2001 | 2012 |
| Role of the INK4a locus in tumor suppression and cell mortality M Serrano, HW Lee, L Chin, C Cordon-Cardo, D Beach, RA DePinho Cell 85 (1), 27-37, 1996 | 1973 | 1996 |
| The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus JJL Jacobs, K Kieboom, S Marino, RA DePinho, M Van Lohuizen Nature 397 (6715), 164-168, 1999 | 1950 | 1999 |
| Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway J Son, CA Lyssiotis, H Ying, X Wang, S Hua, M Ligorio, RM Perera, ... Nature 496 (7443), 101-105, 2013 | 1925 | 2013 |
| FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress Z Tothova, R Kollipara, BJ Huntly, BH Lee, DH Castrillon, DE Cullen, ... Cell 128 (2), 325-339, 2007 | 1793 | 2007 |
| HDAC2 negatively regulates memory formation and synaptic plasticity JS Guan, SJ Haggarty, E Giacometti, JH Dannenberg, N Joseph, J Gao, ... Nature 459 (7243), 55-60, 2009 | 1775 | 2009 |
| Longevity, stress response, and cancer in aging telomerase-deficient mice KL Rudolph, S Chang, HW Lee, M Blasco, GJ Gottlieb, C Greider, ... Cell 96 (5), 701-712, 1999 | 1654 | 1999 |
| Pancreatic cancer biology and genetics N Bardeesy, RA DePinho Nature Reviews Cancer 2 (12), 897-909, 2002 | 1639 | 2002 |
| Essential role of mouse telomerase in highly proliferative organs HW Lee, MA Blasco, GJ Gottlieb, JW Horner, CW Greider, RA DePinho Nature 392 (6676), 569-574, 1998 | 1581 | 1998 |
| Malignant glioma: genetics and biology of a grave matter EA Maher, FB Furnari, RM Bachoo, DH Rowitch, DN Louis, WK Cavenee, ... Genes & development 15 (11), 1311-1333, 2001 | 1563 | 2001 |
| Genetics and biology of pancreatic ductal adenocarcinoma AF Hezel, AC Kimmelman, BZ Stanger, N Bardeesy, RA DePinho Genes & development 20 (10), 1218-1249, 2006 | 1552 | 2006 |
| Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment Q Wang, B Hu, X Hu, H Kim, M Squatrito, L Scarpace, AC DeCarvalho, ... Cancer cell 32 (1), 42-56. e6, 2017 | 1532 | 2017 |
| Telomere dysfunction induces metabolic and mitochondrial compromise E Sahin, S Colla, M Liesa, J Moslehi, FL Müller, M Guo, M Cooper, ... Nature 470 (7334), 359-365, 2011 | 1397 | 2011 |
