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Han Wee Ong
Han Wee Ong
University of North Carolina at Chapel Hill, Eshelman School of Pharmacy
在 live.unc.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Visible‐Light‐Mediated Metal‐Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)−H Alkanes
J Hou, A Ee, H Cao, HW Ong, JH Xu, J Wu
Angewandte Chemie International Edition 57 (52), 17220-17224, 2018
2352018
Visible‐Light‐Induced Selective Defluoroborylation of Polyfluoroarenes, gem‐Difluoroalkenes, and Trifluoromethylalkenes
W Xu, H Jiang, J Leng, HW Ong, J Wu
Angewandte Chemie 132 (10), 4038-4045, 2020
1672020
PROTAC linkerology leads to an optimized bivalent chemical degrader of polycomb repressive complex 2 (PRC2) components
FM Bashore, CA Foley, HW Ong, JM Rectenwald, RP Hanley, ...
ACS chemical biology 18 (3), 494-507, 2023
162023
How many kinases are druggable? A review of our current understanding
B Anderson, P Rosston, HW Ong, MA Hossain, ZW Davis-Gilbert, ...
Biochemical Journal 480 (16), 1331-1363, 2023
112023
Parasite and host kinases as targets for antimalarials
HW Ong, J Adderley, AB Tobin, DH Drewry, C Doerig
Expert Opinion on Therapeutic Targets 27 (2), 151-169, 2023
92023
Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A
X Yang, HW Ong, RJ Dickmander, JL Smith, JW Brown, W Tao, E Chang, ...
ACS omega 8 (42), 39546-39561, 2023
82023
Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore
HW Ong, A Truong, F Kwarcinski, C de Silva, K Avalani, TM Havener, ...
European journal of medicinal chemistry 249, 115043, 2023
82023
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology
A Castano, M Silvestre, CI Wells, JL Sanderson, CA Ferrer, HW Ong, ...
Elife 12, e88206, 2023
72023
CK2 Chemical Probes: Past, Present, and Future
HW Ong, DH Drewry, AD Axtman
Kinases and Phosphatases 1 (4), 288-305, 2023
52023
Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro
KA Galal, A Truong, F Kwarcinski, C de Silva, K Avalani, TM Havener, ...
Journal of Medicinal Chemistry 65 (19), 13172-13197, 2022
42022
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective
HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, ...
ACS Chemical Neuroscience 14 (9), 1672-1685, 2023
32023
A potent and selective CDKL5/GSK3 chemical probe is neuroprotective
HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, ...
bioRxiv, 2023
12023
Coordination of the Hemilabile Ligand Diphenylvinylphosphine to Ru4(µ-H)4(CO)12: Synthesis, Stability and Structural Studies
RKE Neo, HW Ong, ZX Wong, E Kumaran, R Ganguly, WK Leong, ...
Journal of Cluster Science 33 (5), 2337-2343, 2022
12022
Strategic Fluorination to Achieve a Potent, Selective, Metabolically-Stable, and Orally-Bioavailable Inhibitor of CSNK2.
HW Ong, X Yang, J Smith, S Taft-Benz, S Howell, R Dickmander, ...
2024
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication
HW Ong, X Yang, JL Smith, RJ Dickmander, JW Brown, TM Havener, ...
Journal of Medicinal Chemistry, 2024
2024
Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB
HW Ong, C de Silva, K Avalani, F Kwarcinski, CR Mansfield, M Chirgwin, ...
ACS Medicinal Chemistry Letters 14 (12), 1774-1784, 2023
2023
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