Visible‐Light‐Mediated Metal‐Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)−H Alkanes J Hou, A Ee, H Cao, HW Ong, JH Xu, J Wu Angewandte Chemie International Edition 57 (52), 17220-17224, 2018 | 235 | 2018 |
Visible‐Light‐Induced Selective Defluoroborylation of Polyfluoroarenes, gem‐Difluoroalkenes, and Trifluoromethylalkenes W Xu, H Jiang, J Leng, HW Ong, J Wu Angewandte Chemie 132 (10), 4038-4045, 2020 | 167 | 2020 |
PROTAC linkerology leads to an optimized bivalent chemical degrader of polycomb repressive complex 2 (PRC2) components FM Bashore, CA Foley, HW Ong, JM Rectenwald, RP Hanley, ... ACS chemical biology 18 (3), 494-507, 2023 | 16 | 2023 |
How many kinases are druggable? A review of our current understanding B Anderson, P Rosston, HW Ong, MA Hossain, ZW Davis-Gilbert, ... Biochemical Journal 480 (16), 1331-1363, 2023 | 11 | 2023 |
Parasite and host kinases as targets for antimalarials HW Ong, J Adderley, AB Tobin, DH Drewry, C Doerig Expert Opinion on Therapeutic Targets 27 (2), 151-169, 2023 | 9 | 2023 |
Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A X Yang, HW Ong, RJ Dickmander, JL Smith, JW Brown, W Tao, E Chang, ... ACS omega 8 (42), 39546-39561, 2023 | 8 | 2023 |
Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore HW Ong, A Truong, F Kwarcinski, C de Silva, K Avalani, TM Havener, ... European journal of medicinal chemistry 249, 115043, 2023 | 8 | 2023 |
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology A Castano, M Silvestre, CI Wells, JL Sanderson, CA Ferrer, HW Ong, ... Elife 12, e88206, 2023 | 7 | 2023 |
CK2 Chemical Probes: Past, Present, and Future HW Ong, DH Drewry, AD Axtman Kinases and Phosphatases 1 (4), 288-305, 2023 | 5 | 2023 |
Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro KA Galal, A Truong, F Kwarcinski, C de Silva, K Avalani, TM Havener, ... Journal of Medicinal Chemistry 65 (19), 13172-13197, 2022 | 4 | 2022 |
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, ... ACS Chemical Neuroscience 14 (9), 1672-1685, 2023 | 3 | 2023 |
A potent and selective CDKL5/GSK3 chemical probe is neuroprotective HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, ... bioRxiv, 2023 | 1 | 2023 |
Coordination of the Hemilabile Ligand Diphenylvinylphosphine to Ru4(µ-H)4(CO)12: Synthesis, Stability and Structural Studies RKE Neo, HW Ong, ZX Wong, E Kumaran, R Ganguly, WK Leong, ... Journal of Cluster Science 33 (5), 2337-2343, 2022 | 1 | 2022 |
Strategic Fluorination to Achieve a Potent, Selective, Metabolically-Stable, and Orally-Bioavailable Inhibitor of CSNK2. HW Ong, X Yang, J Smith, S Taft-Benz, S Howell, R Dickmander, ... | | 2024 |
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication HW Ong, X Yang, JL Smith, RJ Dickmander, JW Brown, TM Havener, ... Journal of Medicinal Chemistry, 2024 | | 2024 |
Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB HW Ong, C de Silva, K Avalani, F Kwarcinski, CR Mansfield, M Chirgwin, ... ACS Medicinal Chemistry Letters 14 (12), 1774-1784, 2023 | | 2023 |