An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo BJ Aubrey, GL Kelly, AJ Kueh, MS Brennan, L O’Connor, L Milla, S Wilcox, ... Cell reports 10 (8), 1422-1432, 2015 | 389 | 2015 |
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease N Lalaoui, SE Boyden, H Oda, GM Wood, DL Stone, D Chau, L Liu, ... Nature 577 (7788), 103-108, 2020 | 239 | 2020 |
Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture T Thomas, MP Dixon, AJ Kueh, AK Voss Molecular and cellular biology 28 (16), 5093-5105, 2008 | 192 | 2008 |
HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development AJ Kueh, MP Dixon, AK Voss, T Thomas Molecular and cellular biology 31 (4), 845-860, 2011 | 178 | 2011 |
DNA repair processes are critical mediators of p53-dependent tumor suppression A Janic, LJ Valente, MJ Wakefield, L Di Stefano, L Milla, S Wilcox, H Yang, ... Nature medicine 24 (7), 947-953, 2018 | 142 | 2018 |
VDAC2 enables BAX to mediate apoptosis and limit tumor development HS Chin, MX Li, IKL Tan, RL Ninnis, B Reljic, K Scicluna, LF Dagley, ... Nature communications 9 (1), 4976, 2018 | 137 | 2018 |
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation SS Ng, F De Labastida Rivera, J Yan, D Corvino, I Das, P Zhang, R Kuns, ... Nature immunology 21 (10), 1205-1218, 2020 | 129 | 2020 |
Flexible usage and interconnectivity of diverse cell death pathways protect against intracellular infection M Doerflinger, Y Deng, P Whitney, R Salvamoser, S Engel, AJ Kueh, L Tai, ... Immunity 53 (3), 533-547. e7, 2020 | 114 | 2020 |
MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway BN Sheikh, B Phipson, F El-Saafin, HK Vanyai, NL Downer, MJ Bird, ... Oncogene 34 (47), 5807-5820, 2015 | 81 | 2015 |
Transcription factor PU. 1 promotes conventional dendritic cell identity and function via induction of transcriptional regulator DC-SCRIPT M Chopin, AT Lun, Y Zhan, J Schreuder, H Coughlan, A D’Amico, ... Immunity 50 (1), 77-90. e5, 2019 | 79 | 2019 |
DR5 and caspase-8 are dispensable in ER stress-induced apoptosis JA Glab, M Doerflinger, C Nedeva, I Jose, GW Mbogo, JC Paton, ... Cell Death & Differentiation 24 (5), 944-950, 2017 | 76 | 2017 |
A non‐canonical function of Ezh2 preserves immune homeostasis A Vasanthakumar, D Xu, ATL Lun, AJ Kueh, KPJM van Gisbergen, ... EMBO reports 18 (4), 619-631, 2017 | 76 | 2017 |
Loss of NF-κB1 causes gastric cancer with aberrant inflammation and expression of immune checkpoint regulators in a STAT-1-dependent manner LA O’Reilly, TL Putoczki, LA Mielke, JT Low, A Lin, A Preaudet, MJ Herold, ... Immunity 48 (3), 570-583. e8, 2018 | 75 | 2018 |
Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation BJ Klein, SM Jang, C Lachance, W Mi, J Lyu, S Sakuraba, K Krajewski, ... Nature communications 10 (1), 4724, 2019 | 72 | 2019 |
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance LR Garcia, T Tenev, R Newman, RO Haich, G Liccardi, SW John, ... Nature Communications 12 (1), 3364, 2021 | 56 | 2021 |
TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1 L Lionnard, P Duc, MS Brennan, AJ Kueh, M Pal, F Guardia, B Mojsa, ... Cell Death & Differentiation 26 (5), 902-917, 2019 | 52 | 2019 |
The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation SL Vijayaraj, R Feltham, M Rashidi, D Frank, Z Liu, DS Simpson, G Ebert, ... Nature Communications 12 (1), 2713, 2021 | 50 | 2021 |
Loss of p53 causes stochastic aberrant X-chromosome inactivation and female-specific neural tube defects ARD Delbridge, AJ Kueh, F Ke, NM Zamudio, F El-Saafin, N Jansz, ... Cell reports 27 (2), 442-454. e5, 2019 | 49 | 2019 |
TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis C Nedeva, J Menassa, M Duan, C Liu, M Doerflinger, AJ Kueh, MJ Herold, ... Nature immunology 21 (12), 1585-1596, 2020 | 48 | 2020 |
An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles AJ Kueh, M Pal, L Tai, Y Liao, GK Smyth, W Shi, MJ Herold Cell Death & Differentiation 24 (10), 1821-1822, 2017 | 41 | 2017 |