| FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage Q Deng, CJ Holler, G Taylor, KF Hudson, W Watkins, M Gearing, D Ito, ... Journal of Neuroscience 34 (23), 7802-7813, 2014 | 166 | 2014 |
| BACE1 and BACE2 enzymatic activities in Alzheimer’s disease RR Ahmed, CJ Holler, RL Webb, F Li, TL Beckett, MP Murphy Journal of neurochemistry 112 (4), 1045-1053, 2010 | 157 | 2010 |
| Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology CJ Holler, PR Davis, TL Beckett, TL Platt, RL Webb, E Head, MP Murphy Journal of Alzheimer's Disease 42 (4), 1221-1227, 2014 | 125 | 2014 |
| Intracellular proteolysis of progranulin generates stable, lysosomal granulins that are haploinsufficient in patients with frontotemporal dementia caused by GRN mutations CJ Holler, G Taylor, Q Deng, T Kukar Eneuro 4 (4), 2017 | 115 | 2017 |
| Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia CJ Holler, G Taylor, ZT McEachin, Q Deng, WJ Watkins, K Hudson, ... Molecular neurodegeneration 11, 1-17, 2016 | 98 | 2016 |
| BACE2 expression increases in human neurodegenerative disease CJ Holler, RL Webb, AL Laux, TL Beckett, DM Niedowicz, RR Ahmed, ... The American journal of pathology 180 (1), 337-350, 2012 | 77 | 2012 |
| Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations M Huang, E Modeste, E Dammer, P Merino, G Taylor, DM Duong, Q Deng, ... Acta neuropathologica communications 8, 1-25, 2020 | 61 | 2020 |
| Chimeric peptide species contribute to divergent dipeptide repeat pathology in c9ALS/FTD and SCA36 ZT McEachin, TF Gendron, N Raj, M García-Murias, A Banerjee, ... Neuron 107 (2), 292-305. e6, 2020 | 60 | 2020 |
| Polyethyleneimine precipitation versus anion exchange chromatography in fractionating recombinant β-glucuronidase from transgenic tobacco extract C Holler, D Vaughan, C Zhang Journal of chromatography A 1142 (1), 98-105, 2007 | 43 | 2007 |
| Purification of an acidic recombinant protein from transgenic tobacco C Holler, C Zhang Biotechnology and bioengineering 99 (4), 902-909, 2008 | 39 | 2008 |
| STI571 sensitizes breast cancer cells to 5-fluorouracil, cisplatin and camptothecin in a cell type-specific manner JT Sims, S Ganguly, LS Fiore, CJ Holler, ES Park, R Plattner Biochemical pharmacology 78 (3), 249-260, 2009 | 29 | 2009 |
| Effects of nonsteroidal anti-inflammatory drugs on amyloid-β pathology in mouse skeletal muscle TL Beckett, DM Niedowicz, CM Studzinski, AM Weidner, RL Webb, ... Neurobiology of disease 39 (3), 449-456, 2010 | 25 | 2010 |
| Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression TL Beckett, RL Webb, DM Niedowicz, CJ Holler, S Matveev, I Baig, ... Journal of Alzheimer's Disease 32 (1), 127-138, 2012 | 22 | 2012 |
| Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity G Ghag, CJ Holler, G Taylor, TL Kukar, VN Uversky, V Rangachari Protein Science 26 (9), 1759-1772, 2017 | 19 | 2017 |
| APPΔNL695 expression in murine tissue downregulates CNBP expression DM Niedowicz, TL Beckett, CJ Holler, AM Weidner, MP Murphy Neuroscience letters 482 (1), 57-61, 2010 | 16 | 2010 |
| Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency J Root, A Mendsaikhan, S Nandy, G Taylor, M Wang, LT Araujo, P Merino, ... bioRxiv, 2023 | 4 | 2023 |
| Method of purifying acidic proteins expressed in plants C Zhang, C Holler US Patent App. 12/114,507, 2008 | 3 | 2008 |
| A Novel In Vivo‐Active Small Molecule Inducer of Progranulin for the Treatment of Frontotemporal Dementia JF Blain, AYP Chen, MA Brand, JC Lanter, CJ Holler, JK Brendel, ... Alzheimer's & Dementia 18, e061924, 2022 | 2 | 2022 |
| BACE1: Expression, Regulation, and Therapeutic Potential of the Major Alzheimer's Disease Beta-Secretase C J Holler, M P Murphy Current Enzyme Inhibition 9 (1), 3-14, 2013 | 2 | 2013 |
| Cellular Nucleic Acid Binding Protein (CNBP) in Aging and Disease MP Murphy, T Beckett, R Webb, C Holler, D Niedowicz The Faseb Journal 23, 671.7-671.7, 2009 | 2 | 2009 |
