| Design, synthesis, and biological evaluation of 1, 2, 4-triazole bearing 5-substituted biphenyl-2-sulfonamide derivatives as potential antihypertensive candidates J Liu, Q Liu, X Yang, S Xu, H Zhang, R Bai, H Yao, J Jiang, M Shen, X Wu, ... Bioorganic & medicinal chemistry 21 (24), 7742-7751, 2013 | 78 | 2013 |
| Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A3 Receptor X Yang, JPD van Veldhoven, J Offringa, BJ Kuiper, EB Lenselink, ... Journal of medicinal chemistry 62 (7), 3539-3552, 2019 | 47 | 2019 |
| An Affinity-Based Probe for the Human Adenosine A2A Receptor X Yang, TJM Michiels, C de Jong, M Soethoudt, N Dekker, E Gordon, ... Journal of medicinal chemistry 61 (17), 7892-7901, 2018 | 46 | 2018 |
| A covalent antagonist for the human adenosine A2A receptor X Yang, G Dong, TJM Michiels, EB Lenselink, L Heitman, J Louvel, ... Purinergic Signalling 13, 191-201, 2017 | 35 | 2017 |
| Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity R Bai, X Yang, Y Zhu, Z Zhou, W Xie, H Yao, J Jiang, J Liu, M Shen, X Wu, ... Bioorganic & medicinal chemistry 20 (23), 6848-6855, 2012 | 29 | 2012 |
| Synthesis and antitumor activity of novel 3-oxo-23-hydroxybetulinic acid derivatives H Zhang, P Zhu, J Liu, X Yang, S Xu, H Yao, J Jiang, W Ye, X Wu, J Xu European Journal of Medicinal Chemistry 87, 159-167, 2014 | 21 | 2014 |
| Squalene-adenosine nanoparticles: ligands of adenosine receptors or adenosine prodrug? M Rouquette, S Lepetre-Mouelhi, O Dufrançais, X Yang, J Mougin, ... Journal of Pharmacology and Experimental Therapeutics 369 (1), 144-151, 2019 | 19 | 2019 |
| Chiral separation, configurational identification and antihypertensive evaluation of (±)-7, 8-dihydroxy-3-methyl-isochromanone-4 R Bai, J Liu, Y Zhu, X Yang, C Yang, L Kong, X Wang, H Zhang, H Yao, ... Bioorganic & medicinal chemistry letters 22 (20), 6490-6493, 2012 | 17 | 2012 |
| Design and pharmacological profile of a novel covalent partial agonist for the adenosine A1 receptor X Yang, MA Dilweg, D Osemwengie, L Burggraaff, D van der Es, ... Biochemical Pharmacology 180, 114144, 2020 | 16 | 2020 |
| Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism L Xia, H de Vries, X Yang, EB Lenselink, A Kyrizaki, F Barth, J Louvel, ... Biochemical Pharmacology 151, 166-179, 2018 | 16 | 2018 |
| First total synthesis of antihypertensive natural products S-(+)-XJP and R-(−)-XJP C Wang, G Wei, X Yang, H Yao, J Jiang, J Liu, M Shen, X Wu, J Xu Organic & Biomolecular Chemistry 12 (37), 7338-7344, 2014 | 16 | 2014 |
| Molecular probes for the human adenosine receptors X Yang, LH Heitman, AP IJzerman, D van der Es Purinergic signalling 17 (1), 85-108, 2021 | 15 | 2021 |
| Novel hybrids of natural isochroman-4-one bearing N-substituted isopropanolamine as potential antihypertensive candidates R Bai, X Huang, X Yang, W Hong, Y Tang, H Yao, J Jiang, J Liu, M Shen, ... Bioorganic & medicinal chemistry 21 (9), 2495-2502, 2013 | 15 | 2013 |
| Design, Synthesis and Pharmacological Profile of LUF7746, a Novel Covalent Partial Agonist for the Adenosine A1 Receptor X Yang, M Dilweg, D Osemwengie, L Burggraaff, D van der Es, L Heitman, ... | | 2020 |
| Adenosine delivery via squalene-adenosine nanoparticles to treat ischemic diseases: liver versus brain M Rouquette, S Lepetre-Mouelhi, KSL Roux, M Polrot, C Cailleau, X Yang, ... ELSEVIER SCIENCE BV 44 (Supplelment), S12-S12, 2018 | | 2018 |
| To bind or not to bind, that is an important question!: Development of covalent X Yang Purinergic Signal 13 (2), 191-201, 2017 | | 2017 |
| Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, PO Box 9502, 2300RA Leiden, The Netherlands; These authors … X Yang, MA Dilweg, D Osemwengie, L Burggraaff, D van der Es, ... | | |
