| Cancer-associated IDH1 mutations produce 2-hydroxyglutarate L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ... Nature 462 (7274), 739-744, 2009 | 4631 | 2009 |
| Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate PS Ward, CB Thompson Cancer cell 21 (3), 297-308, 2012 | 3368 | 2012 |
| Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation ME Figueroa, O Abdel-Wahab, C Lu, PS Ward, J Patel, A Shih, Y Li, ... Cancer cell 18 (6), 553-567, 2010 | 3072 | 2010 |
| The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate PS Ward, J Patel, DR Wise, O Abdel-Wahab, BD Bennett, HA Coller, ... Cancer cell 17 (3), 225-234, 2010 | 2300 | 2010 |
| IDH mutation impairs histone demethylation and results in a block to cell differentiation C Lu, PS Ward, GS Kapoor, D Rohle, S Turcan, O Abdel-Wahab, ... Nature 483 (7390), 474-478, 2012 | 2166 | 2012 |
| IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype S Turcan, D Rohle, A Goenka, LA Walsh, F Fang, E Yilmaz, C Campos, ... Nature 483 (7390), 479-483, 2012 | 2133 | 2012 |
| Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability DR Wise, PS Ward, JES Shay, JR Cross, JJ Gruber, UM Sachdeva, ... Proceedings of the National Academy of Sciences 108 (49), 19611-19616, 2011 | 1093 | 2011 |
| MitoCarta3. 0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations S Rath, R Sharma, R Gupta, T Ast, C Chan, TJ Durham, RP Goodman, ... Nucleic acids research 49 (D1), D1541-D1547, 2021 | 894 | 2021 |
| Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation J Ye, A Mancuso, X Tong, PS Ward, J Fan, JD Rabinowitz, CB Thompson Proceedings of the National Academy of Sciences 109 (18), 6904-6909, 2012 | 406 | 2012 |
| Signaling in control of cell growth and metabolism PS Ward, CB Thompson Cold Spring Harbor perspectives in biology 4 (7), a006783, 2012 | 312 | 2012 |
| DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia R Rampal, A Alkalin, J Madzo, A Vasanthakumar, E Pronier, J Patel, Y Li, ... Cell reports 9 (5), 1841-1855, 2014 | 308 | 2014 |
| Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition C Chen, Y Liu, C Lu, JR Cross, JP Morris, AS Shroff, PS Ward, JE Bradner, ... Genes & development 27 (18), 1974-1985, 2013 | 217 | 2013 |
| Identification of additional IDH mutations associated with oncometabolite R (−)-2-hydroxyglutarate production PS Ward, JR Cross, C Lu, O Weigert, O Abel-Wahab, RL Levine, ... Oncogene 31 (19), 2491-2498, 2012 | 207 | 2012 |
| The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization PS Ward, C Lu, JR Cross, O Abdel-Wahab, RL Levine, GK Schwartz, ... Journal of Biological Chemistry 288 (6), 3804-3815, 2013 | 192 | 2013 |
| Induction of sarcomas by mutant IDH2 C Lu, S Venneti, A Akalin, F Fang, PS Ward, RG DeMatteo, AM Intlekofer, ... Genes & development 27 (18), 1986-1998, 2013 | 184 | 2013 |
| Combination targeted therapy to disrupt aberrant oncogenic signaling and reverse epigenetic dysfunction in IDH2-and TET2-mutant acute myeloid leukemia AH Shih, C Meydan, K Shank, FE Garrett-Bakelman, PS Ward, ... Cancer discovery 7 (5), 494-505, 2017 | 114 | 2017 |
| Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line AK Simpson, PS Ward, KY Wong, GJ Collord, AM Habib, F Reimann, ... Diabetologia 50 (10), 2181-2189, 2007 | 99 | 2007 |
| Signaling mechanisms underlying the release of glucagon-like peptide 1 F Reimann, PS Ward, FM Gribble Diabetes 55 (Supplement 2), S78-S85, 2006 | 87 | 2006 |
| SnapShot: cancer metabolism pathways LWS Finley, J Zhang, J Ye, PS Ward, CB Thompson Cell metabolism 17 (3), 466-466. e2, 2013 | 58 | 2013 |
| AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML … AH Shih, KR Shank, C Meydan, AM Intlekofer, P Ward, CB Thompson, ... Blood 124 (21), 437-437, 2014 | 37 | 2014 |
