Molecular interactions in posaconazole amorphous solid dispersions from two-dimensional solid-state NMR spectroscopy X Lu, C Huang, MB Lowinger, F Yang, W Xu, CD Brown, D Hesk, ... Molecular pharmaceutics 16 (6), 2579-2589, 2019 | 76 | 2019 |
Achieving a hot melt extrusion design space for the production of solid solutions L Schenck, M Lowinger, GM Troup, L Li, C McKelvey Chemical Engineering in the Pharmaceutical Industry: Drug Product Design …, 2019 | 50 | 2019 |
Recent advances in co-processed APIs and proposals for enabling commercialization of these transformative technologies L Schenck, D Erdemir, L Saunders Gorka, JM Merritt, I Marziano, R Ho, ... Molecular pharmaceutics 17 (7), 2232-2244, 2020 | 47 | 2020 |
Producing amorphous solid dispersions via co-precipitation and spray drying: impact to physicochemical and biopharmaceutical properties AKP Mann, L Schenck, A Koynov, ACF Rumondor, X Jin, M Marota, ... Journal of pharmaceutical sciences 107 (1), 183-191, 2018 | 46 | 2018 |
High-shear rotor–stator wet milling for drug substances: expanding capability with improved scalability A Harter, L Schenck, I Lee, A Cote Organic Process Research & Development 17 (10), 1335-1344, 2013 | 45 | 2013 |
Impact milling of pharmaceutical agglomerates in the wet and dry states LR Schenck, RV Plank International journal of pharmaceutics 348 (1-2), 18-26, 2008 | 45 | 2008 |
Hot-melt extrusion for solid dispersions: composition and design considerations C Brown, J DiNunzio, M Eglesia, S Forster, M Lamm, M Lowinger, ... Amorphous solid dispersions: theory and practice, 197-230, 2014 | 34 | 2014 |
Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; In Vivo and In Vitro Assessment DM Mudie, AM Stewart, N Biswas, TJ Brodeur, KB Shepard, A Smith, ... Molecular Pharmaceutics 17 (12), 4463-4472, 2020 | 31 | 2020 |
Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at high drug loadings L Schenck, AKP Mann, Z Liu, M Milewski, S Zhang, J Ren, K Dewitt, ... International journal of pharmaceutics 559, 147-155, 2019 | 23 | 2019 |
Particle engineering at the drug substance, drug product interface: a comprehensive platform approach to enabling continuous drug substance to drug product processing with … L Schenck, A Koynov, A Cote Drug Development and Industrial Pharmacy 45 (4), 521-531, 2019 | 21 | 2019 |
Optimizing solvent selection and processing conditions to generate high bulk-density, co-precipitated amorphous dispersions of posaconazole D Frank, L Schenck, A Koynov, Y Su, Y Li, N Variankaval Pharmaceutics 13 (12), 2017, 2021 | 16 | 2021 |
Case studies in the development of drug substance control strategies NM Thomson, R Singer, KD Seibert, CV Luciani, S Srivastava, ... Organic Process Research & Development 19 (8), 935-948, 2015 | 13 | 2015 |
HME for solid dispersions: scale-up and late-stage development C Brown, J DiNunzio, M Eglesia, S Forster, M Lamm, M Lowinger, ... Amorphous Solid Dispersions: Theory and Practice, 231-260, 2014 | 13 | 2014 |
Hierarchical particle approach for co-precipitated amorphous solid dispersions for use in preclinical in vivo studies L Schenck, C Boyce, D Frank, S Koranne, HM Ferguson, N Strotman Pharmaceutics 13 (7), 1034, 2021 | 12 | 2021 |
Coprecipitated amorphous dispersions as drug substance: opportunities and challenges NA Strotman, L Schenck Organic Process Research & Development 26 (1), 10-13, 2021 | 11 | 2021 |
A co-processed API approach for a shear sensitive compound affording improved chemical stability and streamlined drug product processing L Schenck, C Neri, X Jia, W Schafer, S Axnanda, N Canfield, F Li, V Shah Journal of Pharmaceutical Sciences 110 (9), 3238-3245, 2021 | 11 | 2021 |
High bulk-density amorphous dispersions to enable direct compression of reduced tablet size amorphous dosage units DS Frank, H Nie, A Chandra, A Coelho, C Dalton, H Dvorak, A Elkhabaz, ... Journal of Pharmaceutical Sciences 112 (8), 2037-2045, 2023 | 7 | 2023 |
Structural modifications of polyethylenimine to control drug loading and release characteristics of amorphous solid dispersions KN Kelsall, LM Foroughi, DS Frank, L Schenck, A LaBuda, AJ Matzger Molecular Pharmaceutics 20 (3), 1779-1787, 2023 | 7 | 2023 |
On the relationship between age of lava flows and radar backscattering RG Blom, P Cooley, LR Schenck IGARSS 1986: Remote Sensing: Today's Solutions for Tomorrow's Information …, 1986 | 7 | 1986 |
Densifying co-precipitated amorphous dispersions to achieve improved bulk powder properties DS Frank, A Punia, M Fahy, C Dalton, J Rowe, L Schenck Pharmaceutical Research 39 (12), 3197-3208, 2022 | 6 | 2022 |