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Luke Schenck
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Molecular interactions in posaconazole amorphous solid dispersions from two-dimensional solid-state NMR spectroscopy
X Lu, C Huang, MB Lowinger, F Yang, W Xu, CD Brown, D Hesk, ...
Molecular pharmaceutics 16 (6), 2579-2589, 2019
762019
Achieving a hot melt extrusion design space for the production of solid solutions
L Schenck, M Lowinger, GM Troup, L Li, C McKelvey
Chemical Engineering in the Pharmaceutical Industry: Drug Product Design …, 2019
502019
Recent advances in co-processed APIs and proposals for enabling commercialization of these transformative technologies
L Schenck, D Erdemir, L Saunders Gorka, JM Merritt, I Marziano, R Ho, ...
Molecular pharmaceutics 17 (7), 2232-2244, 2020
472020
Producing amorphous solid dispersions via co-precipitation and spray drying: impact to physicochemical and biopharmaceutical properties
AKP Mann, L Schenck, A Koynov, ACF Rumondor, X Jin, M Marota, ...
Journal of pharmaceutical sciences 107 (1), 183-191, 2018
462018
High-shear rotor–stator wet milling for drug substances: expanding capability with improved scalability
A Harter, L Schenck, I Lee, A Cote
Organic Process Research & Development 17 (10), 1335-1344, 2013
452013
Impact milling of pharmaceutical agglomerates in the wet and dry states
LR Schenck, RV Plank
International journal of pharmaceutics 348 (1-2), 18-26, 2008
452008
Hot-melt extrusion for solid dispersions: composition and design considerations
C Brown, J DiNunzio, M Eglesia, S Forster, M Lamm, M Lowinger, ...
Amorphous solid dispersions: theory and practice, 197-230, 2014
342014
Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; In Vivo and In Vitro Assessment
DM Mudie, AM Stewart, N Biswas, TJ Brodeur, KB Shepard, A Smith, ...
Molecular Pharmaceutics 17 (12), 4463-4472, 2020
312020
Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at high drug loadings
L Schenck, AKP Mann, Z Liu, M Milewski, S Zhang, J Ren, K Dewitt, ...
International journal of pharmaceutics 559, 147-155, 2019
232019
Particle engineering at the drug substance, drug product interface: a comprehensive platform approach to enabling continuous drug substance to drug product processing with …
L Schenck, A Koynov, A Cote
Drug Development and Industrial Pharmacy 45 (4), 521-531, 2019
212019
Optimizing solvent selection and processing conditions to generate high bulk-density, co-precipitated amorphous dispersions of posaconazole
D Frank, L Schenck, A Koynov, Y Su, Y Li, N Variankaval
Pharmaceutics 13 (12), 2017, 2021
162021
Case studies in the development of drug substance control strategies
NM Thomson, R Singer, KD Seibert, CV Luciani, S Srivastava, ...
Organic Process Research & Development 19 (8), 935-948, 2015
132015
HME for solid dispersions: scale-up and late-stage development
C Brown, J DiNunzio, M Eglesia, S Forster, M Lamm, M Lowinger, ...
Amorphous Solid Dispersions: Theory and Practice, 231-260, 2014
132014
Hierarchical particle approach for co-precipitated amorphous solid dispersions for use in preclinical in vivo studies
L Schenck, C Boyce, D Frank, S Koranne, HM Ferguson, N Strotman
Pharmaceutics 13 (7), 1034, 2021
122021
Coprecipitated amorphous dispersions as drug substance: opportunities and challenges
NA Strotman, L Schenck
Organic Process Research & Development 26 (1), 10-13, 2021
112021
A co-processed API approach for a shear sensitive compound affording improved chemical stability and streamlined drug product processing
L Schenck, C Neri, X Jia, W Schafer, S Axnanda, N Canfield, F Li, V Shah
Journal of Pharmaceutical Sciences 110 (9), 3238-3245, 2021
112021
High bulk-density amorphous dispersions to enable direct compression of reduced tablet size amorphous dosage units
DS Frank, H Nie, A Chandra, A Coelho, C Dalton, H Dvorak, A Elkhabaz, ...
Journal of Pharmaceutical Sciences 112 (8), 2037-2045, 2023
72023
Structural modifications of polyethylenimine to control drug loading and release characteristics of amorphous solid dispersions
KN Kelsall, LM Foroughi, DS Frank, L Schenck, A LaBuda, AJ Matzger
Molecular Pharmaceutics 20 (3), 1779-1787, 2023
72023
On the relationship between age of lava flows and radar backscattering
RG Blom, P Cooley, LR Schenck
IGARSS 1986: Remote Sensing: Today's Solutions for Tomorrow's Information …, 1986
71986
Densifying co-precipitated amorphous dispersions to achieve improved bulk powder properties
DS Frank, A Punia, M Fahy, C Dalton, J Rowe, L Schenck
Pharmaceutical Research 39 (12), 3197-3208, 2022
62022
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