| Characterization of the oxidative metabolites of 17β-estradiol and estrone formed by 15 selectively expressed human cytochrome P450 isoforms AJ Lee, MX Cai, PE Thomas, AH Conney, BT Zhu Endocrinology 144 (8), 3382-3398, 2003 | 593 | 2003 |
| Cigarette smoking and erectile dysfunction: focus on NO bioavailability and ROS generation RC Tostes, FS Carneiro, AJ Lee, FRC Giachini, R Leite, Y Osawa, ... The journal of sexual medicine 5 (6), 1284-1295, 2008 | 146 | 2008 |
| Characterization of the NADPH-dependent metabolism of 17β-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5 AJ Lee, JW Kosh, AH Conney, BT Zhu Journal of Pharmacology and Experimental Therapeutics 298 (2), 420-432, 2001 | 123 | 2001 |
| NADPH-dependent metabolism of 17β-estradiol and estrone to polar and nonpolar metabolites by human tissues and cytochrome P450 isoforms BT Zhu, AJ Lee Steroids 70 (4), 225-244, 2005 | 106 | 2005 |
| Metabolism and disposition of a novel B-cell lymphoma-2 inhibitor venetoclax in humans and characterization of its unusual metabolites H Liu, MJ Michmerhuizen, Y Lao, K Wan, AH Salem, J Sawicki, M Serby, ... Drug Metabolism and Disposition 45 (3), 294-305, 2017 | 79 | 2017 |
| Rapid conversion of tea catechins to monomethylated products by rat liver cytosolic catechol-O-methyltransferase BT Zhu, UK Patel, MX Cai, AJ Lee, AH Conney Xenobiotica 31 (12), 879-890, 2001 | 67 | 2001 |
| Acyl glucuronide metabolites: implications for drug safety assessment TR Van Vleet, H Liu, A Lee, EAG Blomme Toxicology letters 272, 1-7, 2017 | 64 | 2017 |
| NADPH-dependent metabolism of estrone by human liver microsomes AJ Lee, LH Mills, JW Kosh, AH Conney, BT Zhu Journal of Pharmacology and Experimental Therapeutics 300 (3), 838-849, 2002 | 56 | 2002 |
| Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16α-hydroxylation of estrone but not 17β-estradiol AJ Lee, AH Conney, BT Zhu Cancer research 63 (19), 6532-6536, 2003 | 55 | 2003 |
| Contribution of metabolites to P450 inhibition–based drug–drug interactions: scholarship from the drug metabolism leadership group of the innovation and quality consortium … H Yu, SK Balani, W Chen, D Cui, L He, WG Humphreys, J Mao, WG Lai, ... Drug Metabolism and Disposition 43 (4), 620-630, 2015 | 36 | 2015 |
| Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes ER Lowe, AC Everett, AJ Lee, M Lau, AY Dunbar, V Berka, A Tsai, ... Drug metabolism and disposition 33 (1), 131-138, 2005 | 31 | 2005 |
| Pharmacological characterization of A-960656, a histamine H3 receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain M Cowart, G Hsieh, LA Black, CC Zhan, EJ Gomez, M Pai, M Strakhova, ... European Journal of Pharmacology 684 (1-3), 87-94, 2012 | 30 | 2012 |
| Tucatinib inhibits renal transporters OCT2 and MATE without impacting renal function in healthy subjects AR Topletz‐Erickson, AJ Lee, JAG Mayor, EL Rustia, LI Abdulrasool, ... The Journal of Clinical Pharmacology 61 (4), 461-471, 2021 | 23 | 2021 |
| Metabolism and disposition of the hepatitis C protease inhibitor paritaprevir in humans J Shen, M Serby, A Reed, AJ Lee, X Zhang, K Marsh, A Khatri, R Menon, ... Drug Metabolism and Disposition 44 (8), 1164-1173, 2016 | 23 | 2016 |
| Preferential growth stimulation of mammary glands over uterine endometrium in female rats by a naturally occurring estradiol-17β-fatty acid ester LH Mills, AJ Lee, AF Parlow, BT Zhu Cancer research 61 (15), 5764-5770, 2001 | 23 | 2001 |
| Absorption, distribution, metabolism, and excretion of therapeutic proteins: Current industry practices and future perspectives J Bolleddula, K Brady, G Bruin, A Lee, JA Martin, M Walles, K Xu, TY Yang, ... Drug Metabolism and Disposition 50 (6), 837-845, 2022 | 22 | 2022 |
| 4-hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage HJ Choi, AJ Lee, KS Kang, JH Song, BT Zhu Scientific Reports 10 (1), 7283, 2020 | 19 | 2020 |
| Metabolism and disposition of pan-genotypic inhibitor of hepatitis C virus NS5A ombitasvir in humans J Shen, M Serby, B Surber, AJ Lee, J Ma, P Badri, R Menon, O Kavetskaia, ... Drug Metabolism and Disposition 44 (8), 1148-1157, 2016 | 18 | 2016 |
| A 14C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague–Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite AJ Lee, DWA Beno, X Zhang, R Shapiro, M Mason, T Mason-Bright, ... Amino Acids 47, 917-924, 2015 | 18 | 2015 |
| Naturally-occurring estradiol-17β-fatty acid esters, but not estradiol-17β, preferentially induce mammary tumorigenesis in female rats: implications for an important role in … LH Mills, J Yu, XM Xu, AJ Lee, BT Zhu Toxicology and applied pharmacology 229 (3), 332-341, 2008 | 17 | 2008 |
