| Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma S Ueda, S Kitazawa, K Ishida, Y Nishikawa, M Matsui, H Matsumoto, ... The FASEB Journal 24 (7), 2254, 2010 | 131 | 2010 |
| Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines M Tsubaki, M Komai, S Fujimoto, T Itoh, M Imano, K Sakamoto, ... Journal of experimental & clinical cancer research 32, 1-9, 2013 | 125 | 2013 |
| Mangiferin suppresses CIA by suppressing the expression of TNF-α, IL-6, IL-1β, and RANKL through inhibiting the activation of NF-κB and ERK1/2 M Tsubaki, T Takeda, T Kino, T Itoh, M Imano, G Tanabe, O Muraoka, ... American Journal of Translational Research 7 (8), 1371, 2015 | 84 | 2015 |
| Nitrogen-containing bisphosphonates inhibit RANKL-and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation M Tsubaki, M Komai, T Itoh, M Imano, K Sakamoto, H Shimaoka, ... Journal of biomedical science 21, 1-14, 2014 | 75 | 2014 |
| Overexpression of survivin via activation of ERK1/2, Akt, and NF-κB plays a central role in vincristine resistance in multiple myeloma cells M Tsubaki, T Takeda, N Ogawa, K Sakamoto, H Shimaoka, A Fujita, T Itoh, ... Leukemia research 39 (4), 445-452, 2015 | 68 | 2015 |
| Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells D Fujiwara, M Tsubaki, T Takeda, Y Tomonari, Y Koumoto, K Sakaguchi, ... Tumor Biology 39 (10), 1010428317734947, 2017 | 60 | 2017 |
| By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug … M Tsubaki, M Komai, T Itoh, M Imano, K Sakamoto, H Shimaoka, ... Leukemia research 38 (1), 121-130, 2014 | 59 | 2014 |
| The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin‐induced apoptosis is mediated via … M Tsubaki, D Fujiwara, T Takeda, T Kino, Y Tomonari, T Itoh, M Imano, ... Clinical and Experimental Pharmacology and Physiology 44 (2), 222-234, 2017 | 49 | 2017 |
| Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells S Nozaki, T Takeda, T Kitaura, N Takenaka, T Kataoka, T Satoh Cellular signalling 25 (6), 1361-1371, 2013 | 48 | 2013 |
| Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model T Takeda, M Tsubaki, K Sakamoto, E Ichimura, A Enomoto, Y Suzuki, ... Toxicology and applied pharmacology 306, 105-112, 2016 | 45 | 2016 |
| Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase T Takeda, M Tsubaki, T Kino, M Yamagishi, M Iida, T Itoh, M Imano, ... Chemico-Biological Interactions 251, 26-33, 2016 | 45 | 2016 |
| Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP M Tsubaki, N Ogawa, T Takeda, K Sakamoto, H Shimaoka, A Fujita, T Itoh, ... Biomedicine & Pharmacotherapy 68 (8), 999-1005, 2014 | 44 | 2014 |
| Overactivation of Akt contributes to MEK inhibitor primary and acquired resistance in colorectal cancer cells M Tsubaki, T Takeda, M Noguchi, M Jinushi, S Seki, Y Morii, ... Cancers 11 (12), 1866, 2019 | 43 | 2019 |
| Statins improve survival by inhibiting spontaneous metastasis and tumor growth in a mouse melanoma model M Tsubaki, T Takeda, T Kino, N Obata, T Itoh, M Imano, K Mashimo, ... American journal of cancer research 5 (10), 3186, 2015 | 43 | 2015 |
| Inhibition of the tumour necrosis factor-alpha autocrine loop enhances the sensitivity of multiple myeloma cells to anticancer drugs M Tsubaki, M Komai, T Itoh, M Imano, K Sakamoto, H Shimaoka, ... European journal of cancer 49 (17), 3708-3717, 2013 | 41 | 2013 |
| Overexpression of HIF-1α contributes to melphalan resistance in multiple myeloma cells by activation of ERK1/2, Akt, and NF-κB M Tsubaki, T Takeda, Y Tomonari, Y Koumoto, M Imano, T Satou, ... Laboratory Investigation 99 (1), 72-84, 2019 | 40 | 2019 |
| Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway M Tsubaki, T Takeda, M Matsumoto, N Kato, S Yasuhara, Y Koumoto, ... Tumor Biology 40 (10), 1010428318808670, 2018 | 35 | 2018 |
| Pioglitazone inhibits cancer cell growth through STAT3 inhibition and enhanced AIF expression via a PPARγ‐independent pathway M Tsubaki, T Takeda, Y Tomonari, K Kawashima, T Itoh, M Imano, T Satou, ... Journal of Cellular Physiology 233 (4), 3638-3647, 2018 | 34 | 2018 |
| Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells M Tsubaki, K Mashimo, T Takeda, T Kino, A Fujita, T Itoh, M Imano, ... Biomedicine & Pharmacotherapy 78, 23-29, 2016 | 32 | 2016 |
| RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines M Tsubaki, T Takeda, M Yoshizumi, E Ueda, T Itoh, M Imano, T Satou, ... Tumor Biology 37, 9099-9110, 2016 | 31 | 2016 |
