| Selective inhibition of BET bromodomains P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith, O Fedorov, ... Nature 468 (7327), 1067-1073, 2010 | 4325 | 2010 |
| Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty Jr, ... Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006 | 732 | 2006 |
| NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA OY Fedoroff, M Salazar, H Han, VV Chemeris, SM Kerwin, LH Hurley Biochemistry 37 (36), 12367-12374, 1998 | 508 | 1998 |
| RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ... Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013 | 486 | 2013 |
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases O Fedorov, B Marsden, V Pogacic, P Rellos, S Müller, AN Bullock, ... Proceedings of the National Academy of Sciences 104 (51), 20523-20528, 2007 | 416 | 2007 |
| Dual kinase-bromodomain inhibitors for rationally designed polypharmacology P Ciceri, S Müller, A O'mahony, O Fedorov, P Filippakopoulos, JP Hunt, ... Nature chemical biology 10 (4), 305-312, 2014 | 375 | 2014 |
| The (un) targeted cancer kinome O Fedorov, S Müller, S Knapp Nature chemical biology 6 (3), 166-169, 2010 | 366 | 2010 |
| Structure of a DNA: RNA hybrid duplex: why RNase H does not cleave pure RNA OY Fedoroff, M Salazar, BR Reid Journal of molecular biology 233 (3), 509-523, 1993 | 336 | 1993 |
| Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ... Journal of the American Chemical Society 136 (26), 9308-9319, 2014 | 334 | 2014 |
| G-quadruplexes as targets for drug design LH Hurley, RT Wheelhouse, D Sun, SM Kerwin, M Salazar, OY Fedoroff, ... Pharmacology & therapeutics 85 (3), 141-158, 2000 | 300 | 2000 |
| PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ... Cancer research 73 (11), 3336-3346, 2013 | 293 | 2013 |
| Rapid covalent-probe discovery by electrophile-fragment screening E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ... Journal of the American Chemical Society 141 (22), 8951-8968, 2019 | 261 | 2019 |
| CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses A Hammitzsch, C Tallant, O Fedorov, A O’Mahony, PE Brennan, DA Hay, ... Proceedings of the National Academy of Sciences 112 (34), 10768-10773, 2015 | 259 | 2015 |
| 3, 5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands DS Hewings, M Wang, M Philpott, O Fedorov, S Uttarkar, ... Journal of medicinal chemistry 54 (19), 6761-6770, 2011 | 257 | 2011 |
| Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit PV Fish, P Filippakopoulos, G Bish, PE Brennan, ME Bunnage, AS Cook, ... Journal of medicinal chemistry 55 (22), 9831-9837, 2012 | 256 | 2012 |
| Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule A Rangan, OY Fedoroff, LH Hurley Journal of Biological Chemistry 276 (7), 4640-4646, 2001 | 254 | 2001 |
| Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy S Picaud, O Fedorov, A Thanasopoulou, K Leonards, K Jones, J Meier, ... Cancer research 75 (23), 5106-5119, 2015 | 246 | 2015 |
| Structural analysis identifies imidazo [1, 2-b] pyridazines as PIM kinase inhibitors with in vitro antileukemic activity V Pogacic, AN Bullock, O Fedorov, P Filippakopoulos, C Gasser, A Biondi, ... Cancer research 67 (14), 6916-6924, 2007 | 227 | 2007 |
| Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing O Fedorov, K Huber, A Eisenreich, P Filippakopoulos, O King, AN Bullock, ... Chemistry & biology 18 (1), 67-76, 2011 | 221 | 2011 |
| Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits M Soundararajan, FS Willard, AJ Kimple, AP Turnbull, LJ Ball, GA Schoch, ... Proceedings of the National Academy of Sciences 105 (17), 6457-6462, 2008 | 220 | 2008 |
