Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes SL Masters, A Dunne, SL Subramanian, RL Hull, GM Tannahill, FA Sharp, ... Nature immunology 11 (10), 897-904, 2010 | 1437 | 2010 |
Glutamine: metabolism and immune function, supplementation and clinical translation V Cruzat, M Macedo Rogero, K Noel Keane, R Curi, P Newsholme Nutrients 10 (11), 1564, 2018 | 895 | 2018 |
Glutamine and glutamate—their central role in cell metabolism and function P Newsholme, J Procopio, MMR Lima, TC Pithon‐Curi, R Curi Cell biochemistry and function 21 (1), 1-9, 2003 | 826 | 2003 |
Diabetes associated cell stress and dysfunction: role of mitochondrial and non‐mitochondrial ROS production and activity P Newsholme, EP Haber, SM Hirabara, ELO Rebelato, J Procopio, ... The Journal of physiology 583 (1), 9-24, 2007 | 810 | 2007 |
Molecular mechanisms of ROS production and oxidative stress in diabetes P Newsholme, VF Cruzat, KN Keane, R Carlessi, PIH de Bittencourt Jr Biochemical Journal 473 (24), 4527-4550, 2016 | 809 | 2016 |
Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? P Newsholme The Journal of nutrition 131 (9), 2515S-2522S, 2001 | 804 | 2001 |
Molecular mechanisms of glutamine action R Curi, CJ Lagranha, SQ Doi, DF Sellitti, J Procópio, TC Pithon‐Curi, ... Journal of cellular physiology 204 (2), 392-401, 2005 | 588 | 2005 |
Glutamine and glutamate as vital metabolites P Newsholme, MMR Lima, J Procópio, TC Pithon-Curi, RB Bazotte, R Curi Brazilian journal of medical and biological research 36, 153-163, 2003 | 525 | 2003 |
Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages P Newsholme, R Curi, S Gordon, EA Newsholme Biochemical Journal 239 (1), 121-125, 1986 | 490 | 1986 |
The impact of vitamin D levels on inflammatory status: a systematic review of immune cell studies EK Calton, KN Keane, P Newsholme, MJ Soares PloS one 10 (11), e0141770, 2015 | 424 | 2015 |
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease G Verdile, KN Keane, VF Cruzat, S Medic, M Sabale, J Rowles, ... Mediators of inflammation 2015 (1), 105828, 2015 | 409 | 2015 |
Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β‐Cell Dysfunction KN Keane, VF Cruzat, R Carlessi, PIH de Bittencourt Jr, P Newsholme Oxidative medicine and cellular longevity 2015 (1), 181643, 2015 | 396 | 2015 |
Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages P Newsholme, S Gordon, EA Newsholme Biochemical Journal 242 (3), 631-636, 1987 | 354 | 1987 |
New insights into amino acid metabolism, β-cell function and diabetes P Newsholme, L Brennan, B Rubi, P Maechler Clinical science 108 (3), 185-194, 2005 | 336 | 2005 |
Effect of low‐to‐moderate amounts of dietary fish oil on neutrophil lipid composition and function DA Healy, FA Wallace, EA Miles, PC Calder, P Newsholme Lipids 35 (7), 763-768, 2000 | 290 | 2000 |
Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line D Morgan, HR Oliveira-Emilio, D Keane, AE Hirata, M Santos da Rocha, ... Diabetologia 50, 359-369, 2007 | 267 | 2007 |
Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis Y Yuan, VF Cruzat, P Newsholme, J Cheng, Y Chen, Y Lu Mechanisms of ageing and development 155, 10-21, 2016 | 265 | 2016 |
Nutrient regulation of insulin secretion and action P Newsholme, V Cruzat, F Arfuso, K Keane Journal of Endocrinology 221 (3), R105-R120, 2014 | 260 | 2014 |
Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture P Newsholme, EA Newsholme Biochemical Journal 261 (1), 211-218, 1989 | 251 | 1989 |
Amino acid metabolism, insulin secretion and diabetes P Newsholme, K Bender, A Kiely, L Brennan Biochemical Society Transactions 35 (5), 1180-1186, 2007 | 244 | 2007 |