Prioritizing drug targets by perturbing biological network response functions MC Perrone, MG Lerner, M Dunworth, AJ Ewald, JS Bader PLOS Computational Biology 20 (6), e1012195, 2024 | | 2024 |
Methods and compositions using an engineered release factor L Mitchell, JS Bader US Patent App. 18/501,724, 2024 | | 2024 |
Longitudinal change in mitochondrial heteroplasmy exhibits positive selection for deleterious variants LM Kuiper, W Shi, J Verlouw, YS Hong, P Arp, D Puiu, L Broer, J Xie, ... medRxiv, 2024 | | 2024 |
Ensemble Detection of DNA Engineering Signatures A Adler, JS Bader, B Basnight, BW Booth, J Cai, E Cho, JH Collins, Y Ge, ... ACS Synthetic Biology 13 (4), 1105-1115, 2024 | 1 | 2024 |
Proteomic Signature of HIV-Associated Subclinical Left Atrial Remodeling and Incident Heart Failure TE Peterson, VS Hahn, R Moaddel, M Zhu, SA Haberlen, FJ Palella, ... medRxiv, 2024.02. 13.24302797, 2024 | | 2024 |
Manipulating the 3D organization of the largest synthetic yeast chromosome W Zhang, L Lazar-Stefanita, H Yamashita, MJ Shen, LA Mitchell, ... Molecular Cell 83 (23), 4424-4437. e5, 2023 | 15 | 2023 |
Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions Y Zhao, C Coelho, AL Hughes, L Lazar-Stefanita, S Yang, AN Brooks, ... Cell 186 (24), 5220-5236. e16, 2023 | 42 | 2023 |
Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration JL Foo, S Kitano, AV Susanto, Z Jin, Y Lin, Z Luo, L Huang, Z Liang, ... Cell Genomics 3 (11), 2023 | 10 | 2023 |
Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects TC Williams, H Kroukamp, X Xu, ELI Wightman, B Llorente, AR Borneman, ... Cell Genomics 3 (11), 2023 | 8 | 2023 |
Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics BA Blount, X Lu, MRM Driessen, D Jovicevic, MI Sanchez, K Ciurkot, ... Cell Genomics 3 (11), 2023 | 13 | 2023 |
Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains LH McCulloch, V Sambasivam, AL Hughes, N Annaluru, S Ramalingam, ... Cell Genomics 3 (11), 2023 | 9 | 2023 |
Context-dependent neocentromere activity in synthetic yeast chromosome VIII S Lauer, J Luo, L Lazar-Stefanita, W Zhang, LH McCulloch, V Fanfani, ... Cell Genomics 3 (11), 2023 | 11 | 2023 |
Dissecting aneuploidy phenotypes by constructing Sc2. 0 chromosome VII and SCRaMbLEing synthetic disomic yeast Y Shen, F Gao, Y Wang, Y Wang, J Zheng, J Gong, J Zhang, Z Luo, ... Cell genomics 3 (11), 2023 | 19 | 2023 |
Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function J Luo, LA Vale-Silva, AR Raghavan, G Mercy, J Heldrich, X Sun, MK Li, ... Cell Genomics 3 (11), 2023 | 15 | 2023 |
Proteomic Signatures of Human Immunodeficiency Virus-Associated Subclinical Left Atrial Dilation TE Peterson, VS Hahn, S Haberlen, M Plankey, F Palella, J Bader, ... Circulation 148 (Suppl_1), A15132-A15132, 2023 | | 2023 |
Functional Whole Genome Screen of Nutrient-Starved Mycobacterium tuberculosis Identifies Genes Involved in Rifampin Tolerance WM Matern, HT Harris, C Danchik, M McDonald, G Patel, A Srivastava, ... Microorganisms 11 (9), 2269, 2023 | | 2023 |
Pervasive RNA folding is crucial for narnavirus genome maintenance M Fukuda, J Cai, JS Bader, JD Boeke Proceedings of the National Academy of Sciences 120 (26), e2304082120, 2023 | 2 | 2023 |
Priors, population sizes, and power in genome-wide hypothesis tests J Cai, J Zhan, DE Arking, JS Bader BMC bioinformatics 24 (1), 170, 2023 | 2 | 2023 |
Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion YJ Jeong, H Knutsdottir, F Shojaeian, MG Lerner, MF Wissler, E Henriet, ... The Journal of clinical investigation 133 (8), 2023 | 5 | 2023 |
Next-generation large-scale binary protein interaction network for Drosophila melanogaster HW Tang, K Spirohn, Y Hu, T Hao, IA Kovács, Y Gao, R Binari, ... Nature communications 14 (1), 1-16, 2023 | 11* | 2023 |