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Siegfried Hekimi
Siegfried Hekimi
在 mcgill.ca 的电子邮件经过验证 - 首页
标题
引用次数
年份
Understanding Coenzyme Q
Y Wang, N Lilienfeldt, S Hekimi
Physiological Reviews, 2024
2024
Accessory subunit NDUFB4 participates in mitochondrial complex I supercomplex formation
G Parmar, C Fong-McMaster, CA Pileggi, DA Patten, A Cuillerier, S Myers, ...
Journal of Biological Chemistry 300 (2), 2024
2024
Biallelic variants in COQ7 cause distal hereditary motor neuropathy with upper motor neuron signs
AP Rebelo, PJ Tomaselli, J Medina, Y Wang, MF Dohrn, E Nyvltova, ...
Brain 146 (10), 4191-4199, 2023
102023
Novel Homozygous Variant in COQ7 in Siblings With Hereditary Motor Neuropathy
IC Smith, CA Pileggi, Y Wang, K Kernohan, T Hartley, HJ McMillan, ...
Neurology: Genetics 9 (1), e200048, 2023
62023
Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans
CM Haynes, S Hekimi
Genetics 222 (4), iyac160, 2022
162022
Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression
R Branicky, Y Wang, A Khaki, JL Liu, M Kramer-Drauberg, S Hekimi
Science Advances 8 (48), eadc9851, 2022
52022
A novel COQ7 mutation causing primarily neuromuscular pathology and its treatment options
Y Wang, E Gumus, S Hekimi
Molecular Genetics and Metabolism Reports 31, 100877, 2022
212022
The CoQ biosynthetic di-iron carboxylate hydroxylase COQ7 is inhibited by in vivo metalation with manganese but remains function by metalation with cobalt
Y Wang, S Hekimi
MicroPublications biology, 2022
12022
The efficacy of coenzyme Q10 treatment in alleviating the symptoms of primary coenzyme Q10 deficiency: a systematic review
Y Wang, S Hekimi
Journal of Cellular and Molecular Medicine, 2022
182022
Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells
Y Wang, S Hekimi
Cell Death Discovery 7 (1), 201, 2021
82021
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis
MP Rossmann, K Hoi, V Chan, BJ Abraham, S Yang, J Mullahoo, ...
Science 372 (6543), 716-721, 2021
312021
Formulations for improving the delivery of hydrophobic agents
S Hekimi, Y Wang
12021
Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations
Y Wang, S Hekimi
Redox Biology 36, 101680, 2020
202020
ROS regulation of RAS and vulva development in Caenorhabditis elegans
M Kramer-Drauberg, JL Liu, D Desjardins, Y Wang, R Branicky, S Hekimi
PLoS genetics 16 (6), e1008838, 2020
142020
SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans
IE Krabbendam, B Honrath, B Dilberger, EF Iannetti, RS Branicky, ...
Cell death & disease 11 (4), 263, 2020
422020
The complexity of making ubiquinone
Y Wang, S Hekimi
Trends in Endocrinology & Metabolism 30 (12), 929-943, 2019
562019
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling
Y Wang, R Branicky, A Noë, S Hekimi
Journal of Cell Biology 217 (6), 1915-1928, 2018
16182018
Estimating the occurrence of primary ubiquinone deficiency by analysis of large-scale sequencing data
BG Hughes, PM Harrison, S Hekimi
Scientific reports 7 (1), 17744, 2017
362017
Pathogenicity of two COQ7 mutations and responses to 2,4‐dihydroxybenzoate bypass treatment
Y Wang, C Smith, JS Parboosingh, A Khan, M Innes, S Hekimi
Journal of cellular and molecular medicine 21 (10), 2329-2343, 2017
712017
Many possible maximum lifespan trajectories
BG Hughes, S Hekimi
Nature 546 (7660), E8-E9, 2017
452017
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