Optical annealing of peroxo-ferric intermediates in CYP17A1 and product formation. IG Denisov, YV Grinkova, SG Sligar Journal of Inorganic Biochemistry, 112701, 2024 | | 2024 |
Nanodiscs for the study of membrane proteins IG Denisov, SG Sligar Current Opinion in Structural Biology 87, 102844, 2024 | | 2024 |
Cryoradiolysis of oxygenated cytochrome P450 17A1 with lyase substrates generates expected products R Usai, IG Denisov, SG Sligar, JR Kincaid Journal of Inorganic Biochemistry 257, 112582, 2024 | 1 | 2024 |
Selective α-Hydroxyketone Formation and Subsequent C–C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes JHZ Lee, T Coleman, MA Mclean, MN Podgorski, EF Hayball, ISJ Stone, ... ACS Catalysis 14, 8958-8971, 2024 | | 2024 |
Revealing KRas4b topology on the membrane surface S Shree, MA McLean, AG Stephen, SG Sligar Biochemical and Biophysical Research Communications 678, 122-127, 2023 | 2 | 2023 |
Tsuneo Omura-In memory of a Pioneer in cytochrome P450 research. JH Dawson, SG Sligar Journal of Inorganic Biochemistry, 112327-112327, 2023 | | 2023 |
Solvent isotope effects in the catalytic cycle of P450 CYP17A1: Computational modeling of the hydroxylation and lyase reactions IG Denisov, SG Sligar Journal of inorganic biochemistry 243, 112202, 2023 | 3 | 2023 |
Engineering C–C bond cleavage activity into a P450 monooxygenase enzyme JC Miller, JHZ Lee, MA Mclean, RR Chao, ISJ Stone, TL Pukala, ... Journal of the American Chemical Society 145 (16), 9207-9222, 2023 | 11 | 2023 |
Midazolam as a probe for heterotropic drug-drug interactions mediated by CYP3A4 IG Denisov, YV Grinkova, MA McLean, T Camp, SG Sligar Biomolecules 12 (6), 853, 2022 | 11 | 2022 |
Importance of asparagine 202 in manipulating active site structure and substrate preference for human CYP17A1 Y Liu, I Denisov, M Gregory, SG Sligar, JR Kincaid Biochemistry 61 (7), 583-594, 2022 | 6 | 2022 |
Mechanism of the clinically relevant E305G mutation in human P450 CYP17A1 Y Liu, Y Grinkova, MC Gregory, IG Denisov, JR Kincaid, SG Sligar Biochemistry 60 (43), 3262-3271, 2021 | 6 | 2021 |
Revealing the Structure and Function of Membrane Proteins S Sligar PROTEIN SCIENCE 30, 153-154, 2021 | | 2021 |
A Pathfinder in High-Pressure Bioscience: In Memoriam of Gaston Hui Bon Hoa DR Davydov, C Jung, GA Petsko, SG Sligar, JA Kornblatt Biology 10 (8), 778, 2021 | | 2021 |
Midazolam as a probe for drug–drug interactions mediated by cyp3a4: homotropic allosteric mechanism of site-specific hydroxylation IG Denisov, YV Grinkova, T Camp, MA McLean, SG Sligar Biochemistry 60 (21), 1670-1681, 2021 | 23 | 2021 |
Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5 Y Liu, IG Denisov, SG Sligar, JR Kincaid Journal of the American Chemical Society 143 (10), 3729-3733, 2021 | 13 | 2021 |
Nanodiscs: A toolkit for membrane protein science SG Sligar, IG Denisov Protein Science 30 (2), 297-315, 2021 | 111 | 2021 |
Biomimetic chemical sensors using nanoelectronic readout of olfactory receptors AT Johnson Jr, BR Goldsmith, JJ Mitala, BM Discher, SG Sligar, ... US Patent 10,900,971, 2021 | | 2021 |
P450 CYP17A1 variant with a disordered proton shuttle assembly retains peroxo‐mediated lyase efficiency Y Liu, IG Denisov, YV Grinkova, SG Sligar, JR Kincaid Chemistry–A European Journal 26 (70), 16846-16852, 2020 | 9 | 2020 |
Dark, ultra-dark and ultra-bright nanodiscs for membrane protein investigations MA McLean, IG Denisov, YV Grinkova, SG Sligar Analytical biochemistry 607, 113860, 2020 | 6 | 2020 |
A modified vilsmeier–haack strategy to construct β-pyridine-fused 5, 10, 15, 20-tetraarylporphyrins P Singh, M Nath SynOpen 4 (02), 44-50, 2020 | 9 | 2020 |