Methods to prevent teratogenicity of imid like molecules and imid based degraders/protacs ES Fischer, K Donovan US Patent App. 18/371,858, 2024 | | 2024 |
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML W Bourgeois, JA Cutler, BJ Aubrey, DV Wenge, F Perner, C Martucci, ... Blood 143 (15), 1513-1527, 2024 | 2 | 2024 |
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF S Radko-Juettner, H Yue, JA Myers, RD Carter, AN Robertson, P Mittal, ... Nature 628 (8007), 442-449, 2024 | | 2024 |
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates HT Huang, RJ Lumpkin, RW Tsai, S Su, X Zhao, Y Xiong, J Chen, ... Nature Chemical Biology, 1-10, 2024 | | 2024 |
Continuous evolution of compact protein degradation tags regulated by selective molecular glues JAM Mercer, SJ DeCarlo, SS Roy Burman, V Sreekanth, AT Nelson, ... Science 383 (6688), eadk4422, 2024 | 2 | 2024 |
Sulfonamide derivatives for protein degradation NS Gray, E Fischer, H Yoon, T Zhang, T Faust, K Donovan, CAI Quan, Z Li US Patent App. 18/375,003, 2024 | | 2024 |
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation EC Erickson, I You, G Perry, A Dugourd, KA Donovan, C Crafter, ... Science Signaling 17 (825), eadf2670, 2024 | 1 | 2024 |
HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent L Wang, S Shi, A Unterreiner, R Kapetanovic, S Ghosh, J Sanchez, ... Journal of Biological Chemistry 300 (2), 2024 | | 2024 |
Proteolysis-targeting chimeras with reduced off-targets TM Nguyen, V Sreekanth, A Deb, P Kokkonda, PK Tiwari, KA Donovan, ... Nature Chemistry 16 (2), 218-228, 2024 | 18 | 2024 |
Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library H Razumkov, Z Jiang, K Baek, I You, Q Geng, K Donovan, MT Tang, ... bioRxiv, 2024.05. 04.592550, 2024 | | 2024 |
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators Y Liu, RP Nowak, J Che, KA Donovan, F Huerta, H Liu, RJ Metivier, ... RSC Medicinal Chemistry, 2024 | | 2024 |
Design principles for cyclin K molecular glue degraders Z Kozicka, DJ Suchyta, V Focht, G Kempf, G Petzold, M Jentzsch, C Zou, ... Nature Chemical Biology 20 (1), 93-102, 2024 | 14 | 2024 |
Menin Inhibitor Induced Menin Protein Degradation Contributes to Menin Inhibitor Efficacy J Cutler, J Tsai, B Regalado, W Bourgeois, D Wenge, J Kim, R Nowak, ... Blood 142, 2788, 2023 | | 2023 |
Sulfonamide derivatives for protein degradation NS Gray, E Fischer, H Yoon, T Zhang, T Faust, K Donovan, CAI Quan, Z Li US Patent 11,807,606, 2023 | | 2023 |
Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange JT Cruite, RP Nowak, KA Donovan, SB Ficarro, H Huang, H Liu, Y Liu, ... ACS Medicinal Chemistry Letters 14 (11), 1576-1581, 2023 | 2 | 2023 |
Proteomics‐Based Discovery of First‐in‐Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2) W Ji, WS Byun, W Lu, X Zhu, KA Donovan, BG Dwyer, J Che, L Yuan, ... Angewandte Chemie International Edition 62 (43), e202308292, 2023 | 1 | 2023 |
Ligands to cereblon (crbn) N Gray, T Zhang, E Fischer, Z He, G Du, K Donovan, R Nowak, JTC Yuan US Patent App. 17/985,415, 2023 | | 2023 |
Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity E Koide, ML Mohardt, ZM Doctor, A Yang, M Hao, KA Donovan, ... ChemBioChem 24 (19), e202300141, 2023 | 6 | 2023 |
Small molecule degraders of polybromo-1 (PBRM1) E Fischer, N Gray, R Nowak, K Donovan, T Zhang, Y Liu US Patent 11,771,697, 2023 | | 2023 |
Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry RC Sarott, I You, YD Li, ST Toenjes, KA Donovan, P Seo, M Ordonez, ... Journal of the American Chemical Society 145 (40), 21937-21944, 2023 | 10 | 2023 |