关注
Katherine A Donovan
Katherine A Donovan
Dana-Farber Cancer Institute, Harvard Medical School
在 crystal.harvard.edu 的电子邮件经过验证
标题
引用次数
年份
Methods to prevent teratogenicity of imid like molecules and imid based degraders/protacs
ES Fischer, K Donovan
US Patent App. 18/371,858, 2024
2024
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML
W Bourgeois, JA Cutler, BJ Aubrey, DV Wenge, F Perner, C Martucci, ...
Blood 143 (15), 1513-1527, 2024
22024
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF
S Radko-Juettner, H Yue, JA Myers, RD Carter, AN Robertson, P Mittal, ...
Nature 628 (8007), 442-449, 2024
2024
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates
HT Huang, RJ Lumpkin, RW Tsai, S Su, X Zhao, Y Xiong, J Chen, ...
Nature Chemical Biology, 1-10, 2024
2024
Continuous evolution of compact protein degradation tags regulated by selective molecular glues
JAM Mercer, SJ DeCarlo, SS Roy Burman, V Sreekanth, AT Nelson, ...
Science 383 (6688), eadk4422, 2024
22024
Sulfonamide derivatives for protein degradation
NS Gray, E Fischer, H Yoon, T Zhang, T Faust, K Donovan, CAI Quan, Z Li
US Patent App. 18/375,003, 2024
2024
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation
EC Erickson, I You, G Perry, A Dugourd, KA Donovan, C Crafter, ...
Science Signaling 17 (825), eadf2670, 2024
12024
HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent
L Wang, S Shi, A Unterreiner, R Kapetanovic, S Ghosh, J Sanchez, ...
Journal of Biological Chemistry 300 (2), 2024
2024
Proteolysis-targeting chimeras with reduced off-targets
TM Nguyen, V Sreekanth, A Deb, P Kokkonda, PK Tiwari, KA Donovan, ...
Nature Chemistry 16 (2), 218-228, 2024
182024
Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library
H Razumkov, Z Jiang, K Baek, I You, Q Geng, K Donovan, MT Tang, ...
bioRxiv, 2024.05. 04.592550, 2024
2024
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators
Y Liu, RP Nowak, J Che, KA Donovan, F Huerta, H Liu, RJ Metivier, ...
RSC Medicinal Chemistry, 2024
2024
Design principles for cyclin K molecular glue degraders
Z Kozicka, DJ Suchyta, V Focht, G Kempf, G Petzold, M Jentzsch, C Zou, ...
Nature Chemical Biology 20 (1), 93-102, 2024
142024
Menin Inhibitor Induced Menin Protein Degradation Contributes to Menin Inhibitor Efficacy
J Cutler, J Tsai, B Regalado, W Bourgeois, D Wenge, J Kim, R Nowak, ...
Blood 142, 2788, 2023
2023
Sulfonamide derivatives for protein degradation
NS Gray, E Fischer, H Yoon, T Zhang, T Faust, K Donovan, CAI Quan, Z Li
US Patent 11,807,606, 2023
2023
Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange
JT Cruite, RP Nowak, KA Donovan, SB Ficarro, H Huang, H Liu, Y Liu, ...
ACS Medicinal Chemistry Letters 14 (11), 1576-1581, 2023
22023
Proteomics‐Based Discovery of First‐in‐Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2)
W Ji, WS Byun, W Lu, X Zhu, KA Donovan, BG Dwyer, J Che, L Yuan, ...
Angewandte Chemie International Edition 62 (43), e202308292, 2023
12023
Ligands to cereblon (crbn)
N Gray, T Zhang, E Fischer, Z He, G Du, K Donovan, R Nowak, JTC Yuan
US Patent App. 17/985,415, 2023
2023
Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity
E Koide, ML Mohardt, ZM Doctor, A Yang, M Hao, KA Donovan, ...
ChemBioChem 24 (19), e202300141, 2023
62023
Small molecule degraders of polybromo-1 (PBRM1)
E Fischer, N Gray, R Nowak, K Donovan, T Zhang, Y Liu
US Patent 11,771,697, 2023
2023
Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry
RC Sarott, I You, YD Li, ST Toenjes, KA Donovan, P Seo, M Ordonez, ...
Journal of the American Chemical Society 145 (40), 21937-21944, 2023
102023
系统目前无法执行此操作,请稍后再试。
文章 1–20