Decoding and overcoming T cell exhaustion: Epigenetic and transcriptional dynamics in CAR-T cells against solid tumors T Ahn, EA Bae, H Seo Molecular Therapy 32 (6), 1617-1627, 2024 | | 2024 |
PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion JL Hope, DC Otero, EA Bae, CJ Stairiker, AB Palete, HA Faso, M Lin, ... Cell reports 42 (5), 2023 | 10 | 2023 |
Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities Z Lu, EA Bae, II Verginadis, H Zhang, C Cho, N McBrearty, SS George, ... Cancer Immunology, Immunotherapy 72 (4), 815-826, 2023 | 3 | 2023 |
MicroRNA-139 expression is dispensable for the generation of influenza-specific CD8+ T cell responses JL Hope, M Zhao, CJ Stairiker, CH Kiernan, AJ Carey, YM Mueller, ... The Journal of Immunology 208 (3), 603-617, 2022 | 2 | 2022 |
PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells JL Hope, DC Otero, EA Bae, CJ Stairiker, AB Palete, HA Faso, ... bioRxiv, 2022.01. 24.477602, 2022 | | 2022 |
RNF5-deficiency inhibits CD8+ T cell exhaustion in chronic antigen stimulation E Bae, JL Hope, DC Otero, HA Faso, AB Palete, ZA Ronai, LM Bradley The Journal of Immunology 206 (1_Supplement), 14.12-14.12, 2021 | 1 | 2021 |
PSGL-1 is an early T cell signaling regulator that drives immunometabolism and terminal differentiation in tumor-specific CD8 T cells. JL Hope, DC Otero, E Bae, CJ Stairiker, AB Palete, HA Faso, P de Jong, ... CANCER IMMUNOLOGY RESEARCH 9 (2), 2021 | | 2021 |
Abstract PO014: PSGL-1 is an early T cell signaling regulator that drives immunometabolism and terminal differentiation in tumor-specific CD8 T cells JL Hope, DC Otero, E Bae, CJ Stairiker, AB Palete, HA Faso, P de Jong, ... Cancer Immunology Research 9 (2_Supplement), PO014-PO014, 2021 | | 2021 |
Enhanced ER stress responses accompany greater effector T cell functions with deficiency of PSGL-1 E Bae, JL Hope, DC Otero, CJ Stairiker, HA Faso, AB Palete, LM Bradley The Journal of Immunology 204 (1_Supplement), 150.9-150.9, 2020 | | 2020 |
Immunometabolism regulation by PSGL-1 signaling in tumor-specific CD8 T cells JL Hope, DC Otero, E Bae, CJ Stairiker, AB Palete, HA Faso, P de Jong, ... The Journal of Immunology 204 (1_Supplement), 240.1-240.1, 2020 | | 2020 |
GITR agonism triggers antitumor immune responses through IL21-expressing follicular helper T cells CH Koh, IK Kim, KS Shin, I Jeon, B Song, JM Lee, EA Bae, H Seo, ... Cancer Immunology Research 8 (5), 698-709, 2020 | 11 | 2020 |
Differentiation of c‐Kit+CD24+ natural killer cells into myeloid cells in a GATA‐2‐dependent manner B Song, JM Lee, YJ Park, IK Kim, BS Kim, KS Shin, I Jeon, CH Koh, ... The FASEB Journal 34 (3), 4462-4481, 2020 | 4 | 2020 |
Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection KS Shin, I Jeon, BS Kim, IK Kim, YJ Park, CH Koh, B Song, JM Lee, J Lim, ... Frontiers in Immunology 10, 1887, 2019 | 42 | 2019 |
Striking a balance—cellular and molecular drivers of memory T cell development and responses to chronic stimulation JL Hope, CJ Stairiker, EA Bae, DC Otero, LM Bradley Frontiers in immunology 10, 1595, 2019 | 35 | 2019 |
Roles of NKT cells in cancer immunotherapy EA Bae, H Seo, IK Kim, I Jeon, CY Kang Archives of pharmacal research 42, 543-548, 2019 | 102 | 2019 |
GM-CSF promotes antitumor immunity by inducing Th9 cell responses IK Kim, CH Koh, I Jeon, KS Shin, TS Kang, EA Bae, H Seo, HJ Ko, BS Kim, ... Cancer Immunology Research 7 (3), 498-509, 2019 | 30 | 2019 |
Activation of NKT cells in an anti-PD-1–resistant tumor model enhances antitumor immunity by reinvigorating exhausted CD8 T cells EA Bae, H Seo, BS Kim, J Choi, I Jeon, KS Shin, CH Koh, B Song, IK Kim, ... Cancer research 78 (18), 5315-5326, 2018 | 61 | 2018 |
IL21 therapy combined with PD-1 and Tim-3 blockade provides enhanced NK cell antitumor activity against MHC class I–deficient tumors H Seo, BS Kim, EA Bae, BS Min, YD Han, SJ Shin, CY Kang Cancer immunology research 6 (6), 685-695, 2018 | 43 | 2018 |
NKT cell ligand-induced cytokines enhance antitumor effects with PD-1 blockade by reinvigorating exhausted CD8 T cells. E Bae, H Seo, J Choi, J Lee, CY Kang The Journal of Immunology 200 (1_Supplement), 122.18-122.18, 2018 | | 2018 |
IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours H Seo, I Jeon, BS Kim, M Park, EA Bae, B Song, CH Koh, KS Shin, IK Kim, ... Nature communications 8 (1), 15776, 2017 | 154 | 2017 |