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Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia Z Lu, Q Lai, Z Li, M Zhong, Y Jiang, L Feng, J Zha, J Yao, Y Li, X Deng, ... Current Medical Science, 1-11, 2024 | | 2024 |
Small molecule myristate inhibitors of Bcr-abl and methods of use NS Gray, J Zhang, B Okram, X Deng, JW Chang, A Wojciechowski US Patent 11,932,646, 2024 | | 2024 |
SPAK inhibitor ZT‐1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia MIH Bhuiyan, K Habib, MT Sultan, F Chen, I Jahan, Z Weng, MS Rahman, ... CNS Neuroscience & Therapeutics 30 (3), e14654, 2024 | 1 | 2024 |
Unveiling the State Transition Mechanisms of Ras Proteins through Enhanced Sampling and QM/MM Simulations F Hu, Y Wang, J Zeng, X Deng, F Xia, X Xu The Journal of Physical Chemistry B, 2024 | 1 | 2024 |
Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1 T Zeng, T Jiang, B Zhang, T Zhang, W Dai, X Yin, Y Li, C Wu, Y Wu, X Chi, ... bioRxiv, 2024.04. 26.591418, 2024 | | 2024 |
Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis W Li, Y Huang, Y Lin, B Zhang, MY Li, Y Zou, G Hu, Y He, J Yang, B Xie, ... Cell Reports 42 (11), 2023 | 2 | 2023 |
Type II raf kinase inhibitors NS Gray, HG Choi, X Deng, J Zhang US Patent 11,826,365, 2023 | | 2023 |
Discovery of urea-based pleuromutilin derivatives as potent gram-positive antibacterial agents Z Wu, X Zhu, A Hong, G He, Z Wang, Q Xu, Z Hu, X Wu, Y Wang, Q Chen, ... Bioorganic Chemistry 136, 106547, 2023 | 4 | 2023 |
Exploring Diversity through Dimerization in Natural Products by a Rational Tandem Mass-Based Molecular Network Strategy L Li, Y Wang, N Chen, X Li, H Li, L Jin, Y Ou, XJ Kong, S Cao, Q Xu, X Wu, ... Organic Letters 25 (22), 4016-4021, 2023 | 1 | 2023 |
Rational design of a polysaccharide-based viral mimicry nanocomplex for potent gene silencing in inflammatory tissues H Gao, S Wang, Q Long, R Cheng, W Lian, A Koivuniemi, M Ma, B Zhang, ... Journal of Controlled Release 357, 120-132, 2023 | 3 | 2023 |
Human polo-like kinase inhibitors as antiplasmodials MJ Bohmer, J Wang, ES Istvan, MR Luth, JE Collins, EL Huttlin, L Wang, ... ACS Infectious Diseases 9 (4), 1004-1021, 2023 | 2 | 2023 |
Bicyclomycin Activity against Multidrug-Resistant Gram-Negative Pathogens W Wang, X Zhu, H Luo, Z Wang, A Hong, J Zeng, L Li, D Wang, X Deng, ... Microbiology Spectrum 11 (1), e03790-22, 2023 | 1 | 2023 |
STK19 inhibitors for treatment of cancer CUI Rutao, YIN Chengqian, X Deng, T Zhang US Patent 11,542,240, 2023 | 1 | 2023 |
Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice MIH Bhuiyan, S Fischer, SM Patel, H Oft, T Zhang, LM Foley, J Zhang, ... Neurochemistry international 162, 105441, 2023 | 4 | 2023 |
Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms X Zhu, A Hong, X Sun, W Wang, G He, H Luo, Z Wu, Q Xu, Z Hu, X Wu, ... Frontiers in Cellular and Infection Microbiology 12, 1055929, 2022 | 2 | 2022 |
Atomic resolution Cryo-EM structure of human proteasome activator PA28γ DD Chen, J Hao, CH Shen, XM Deng, CH Yun International Journal of Biological Macromolecules 219, 500-507, 2022 | 6 | 2022 |
Paspalines C–D and Paxillines B–D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69 W Lin, H Li, Z Wu, J Su, Z Zhang, L Yang, X Deng, Q Xu Marine Drugs 20 (11), 684, 2022 | 4 | 2022 |
Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system H Guo, J Wang, S Ren, LF Zheng, YX Zhuang, DL Li, HH Sun, LY Liu, ... Nature Communications 13 (1), 6004, 2022 | 18 | 2022 |
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma Q Chen, Z Zhang, Q Huang, H Chen, W Hong, T Lin, W Zhao, X Wang, ... Nature metabolism 4 (10), 1306-1321, 2022 | 42 | 2022 |