Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells JE Park, TS Kim, Y Zeng, M Mikolaj, J Il Ahn, MS Alam, CM Monnie, V Shi, ... Nature Communications 15 (1), 2017, 2024 | 1 | 2024 |
Plk1 polo box domain inhibitors and method of treating cancer KS Lee, KA Jacobson, CN Alverez, JE Park, P Oliva, H Lee, KP Kirsch US Patent App. 18/028,463, 2023 | | 2023 |
Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition JE Park, K Kirsch, H Lee, P Oliva, JI Ahn, H Ravishankar, Y Zeng, SD Fox, ... Proceedings of the National Academy of Sciences 120 (35), e2305037120, 2023 | 1 | 2023 |
Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr• VprBP• Plk4 complex in CD4+ T cells K Lee, JE Park, TS Kim, Y Zeng, C Monnie, M Alam, M Zhou, M Mikolaj, ... | | 2023 |
Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells J Il Ahn, L Zhang, H Ravishankar, L Fan, K Kirsch, Y Zeng, L Meng, ... Communications Biology 6 (1), 712, 2023 | 1 | 2023 |
Structural optimization and anticancer activity of Polo-Like Kinase 1 (Plk1) polo-box domain (PBD) Inhibitors and their prodrugs JE Park, H Lee, P Oliva, K Kirsch, B Kim, JI Ahn, CN Alverez, S Gaikwad, ... ACS Pharmacology & Translational Science 6 (3), 422-446, 2023 | 2 | 2023 |
Author Correction: Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells JI Ahn, L Zhang, H Ravishankar, L Fan, K Kirsch, Y Zeng, L Meng, JE Park, ... Communications Biology 6, 2023 | | 2023 |
Self‐assembling Long Coiled‐coil Proteins Driving the Formation of a Nanoscale Cylindrical Architecture at Human Centrosomes JI Ahn, H Ravishankar, KP Kirsch, JE Park, KS Lee The FASEB Journal 36, 2022 | | 2022 |
Novel macrocyclic peptidomimetics targeting the polo-box domain of polo-like kinase 1 SS Ryu, JE Park, YJ Ham, DC Lim, NP Kwiatkowski, DH Kim, D Bhunia, ... Journal of medicinal chemistry 65 (3), 1915-1932, 2022 | 5 | 2022 |
Constructing PCM with architecturally distinct higher-order assemblies KS Lee, JE Park, J il Ahn, Y Zeng Current Opinion in Structural Biology 66, 66-73, 2021 | 17 | 2021 |
Autophosphorylation-induced self-assembly and STIL-dependent reinforcement underlie Plk4’s ring-to-dot localization conversion around a human centriole JE Park, L Meng, EK Ryu, K Nagashima, U Baxa, JK Bang, KS Lee Cell Cycle 19 (24), 3419-3436, 2020 | 5 | 2020 |
Phase separation of the Cep63• Cep152 complex underlies the formation of dynamic supramolecular self-assemblies at human centrosomes JI Ahn, JE Park, L Meng, L Zhang, TS Kim, MJ Kruhlak, BY Kim, KS Lee Cell Cycle 19 (24), 3437-3457, 2020 | 14 | 2020 |
Identification of a new heterocyclic scaffold for inhibitors of the polo-box domain of polo-like kinase 1 CN Alverez, JE Park, KS Toti, Y Xia, KW Krausz, G Rai, JK Bang, ... Journal of medicinal chemistry 63 (22), 14087-14117, 2020 | 16 | 2020 |
Development of a polo-like kinase-1 polo-box domain inhibitor as a tumor growth suppressor in mice models P Gunasekaran, MS Yim, M Ahn, NK Soung, JE Park, J Kim, G Bang, ... Journal of medicinal chemistry 63 (23), 14905-14920, 2020 | 18 | 2020 |
A self-assembled cylindrical platform for Plk4-induced centriole biogenesis KS Lee, JE Park, J Il Ahn, Z Wei, L Zhang Open Biology 10 (8), 200102, 2020 | 7 | 2020 |
Requirement of the Cep57-Cep63 interaction for proper Cep152 recruitment and centriole duplication Z Wei, TS Kim, JI Ahn, L Meng, Y Chen, EK Ryu, B Ku, M Zhou, SJ Kim, ... Molecular and cellular biology 40 (10), e00535-19, 2020 | 32 | 2020 |
Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis JE Park, L Zhang, JK Bang, T Andresson, F DiMaio, KS Lee Nature communications 10 (1), 4959, 2019 | 64 | 2019 |
Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use TR Burke Jr, F Liu, KS Lee, JE Park US Patent 10,266,565, 2019 | 3 | 2019 |
Molecular architecture of a cylindrical self-assembly at human centrosomes TS Kim, L Zhang, J Il Ahn, L Meng, Y Chen, E Lee, JK Bang, JM Lim, ... Nature communications 10 (1), 1151, 2019 | 40 | 2019 |
Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use W Qian, JE Park, CC Lai, JA Kelley, KS Lee, TR Burke Jr US Patent 10,047,122, 2018 | | 2018 |