Editorial overview: Four dimensions of innate immunity D Bogunovic, ZJ Chen Current Opinion in Immunology 75, 102174, 2022 | | 2022 |
TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance T Li, S Yum, M Li, X Chen, X Zuo, ZJ Chen Journal of Experimental Medicine 219 (1), e20211539, 2021 | 33 | 2021 |
cGAS restricts colon cancer development by protecting intestinal barrier integrity S Hu, Y Fang, X Chen, T Cheng, M Zhao, M Du, T Li, M Li, Z Zeng, Y Wei, ... Proceedings of the National Academy of Sciences 118 (23), e2105747118, 2021 | 49 | 2021 |
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections S Yum, M Li, Y Fang, ZJ Chen Proceedings of the National Academy of Sciences 118 (14), e2100225118, 2021 | 318 | 2021 |
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis T Li, T Huang, M Du, X Chen, F Du, J Ren, ZJ Chen Science 371 (6535), eabc5386, 2021 | 168 | 2021 |
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression K Zhang, L Miorin, T Makio, I Dehghan, S Gao, Y Xie, H Zhong, M Esparza, ... Science Advances 7 (6), eabe7386, 2021 | 187 | 2021 |
MLH1 deficiency-triggered DNA hyperexcision by exonuclease 1 activates the cGAS-STING pathway J Guan, C Lu, Q Jin, H Lu, X Chen, L Tian, Y Zhang, J Ortega, J Zhang, ... Cancer cell 39 (1), 109-121. e5, 2021 | 147 | 2021 |
cGAS suppresses genomic instability as a decelerator of replication forks H Chen, H Chen, J Zhang, Y Wang, A Simoneau, H Yang, AS Levine, ... Science advances 6 (42), eabb8941, 2020 | 96 | 2020 |
STEEP mediates STING ER exit and activation of signaling B Zhang, R Nandakumar, LS Reinert, J Huang, A Laustsen, Z Gao, C Sun, ... Nature immunology 21 (8), 868-879, 2020 | 106 | 2020 |
Old dogs, new trick: classic cancer therapies activate cGAS S Yum, M Li, ZJ Chen Cell research 30 (8), 639-648, 2020 | 139 | 2020 |
Structures and mechanisms in the cGAS-STING innate immunity pathway X Zhang, X Bai, ZJ Chen Immunity 53 (1), 43-53, 2020 | 416 | 2020 |
Type I interferon response in radiation-induced anti-tumor immunity F Zhang, S Manna, LM Pop, ZJ Chen, YX Fu, R Hannan Seminars in radiation oncology 30 (2), 129-138, 2020 | 28 | 2020 |
–The Garibaldi Volcanic Belt Geothermal Energy Project–Mount Meager 2019 Field Program SE Grasby, SM Ansari, R Bryant, A Calahorrano-DiPatre, Z Chen, ... Garibaldi Geothermal Energy Project, 1, 2020 | 6 | 2020 |
Discovery of small-molecule cyclic GMP-AMP synthase inhibitors R Padilla-Salinas, L Sun, R Anderson, X Yang, S Zhang, ZJ Chen, H Yin The Journal of Organic Chemistry 85 (3), 1579-1600, 2019 | 60 | 2019 |
Structural basis of STING binding with and phosphorylation by TBK1 C Zhang, G Shang, X Gui, X Zhang, X Bai, ZJ Chen Nature 567 (7748), 394-398, 2019 | 719 | 2019 |
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway X Gui, H Yang, T Li, X Tan, P Shi, M Li, F Du, ZJ Chen Nature 567 (7747), 262-266, 2019 | 892 | 2019 |
cGAS in action: Expanding roles in immunity and inflammation A Ablasser, ZJ Chen Science 363 (6431), eaat8657, 2019 | 750 | 2019 |
Roles of the cGAS-STING pathway in cancer immunosurveillance and immunotherapy S Yum, M Li, AE Frankel, ZJ Chen Annual review of cancer biology 3 (1), 323-344, 2019 | 79 | 2019 |
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP G Shang, C Zhang, ZJ Chen, X Bai, X Zhang Nature 567 (7748), 389-393, 2019 | 526 | 2019 |
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation J Chen, ZJ Chen Nature 564 (7734), 71-76, 2018 | 572 | 2018 |