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Filip Van Petegem
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Abstract 2237 Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals sub-conductance that is abolished by PKA phosphorylation
O Haji-Ghassemi, F Van Petegem, H Valdivia, S Chen, K Woll, G Gurrola, ...
Journal of Biological Chemistry 300 (3), 2024
2024
Research Note: Clostridium perfringens NetB and CnaA neutralizing nanobodies in feed reduce the incidence of poultry necrotic enteritis
SA Loutet, S Cheung, S Zaytsoff, C Hofacre, MK Jones, F Van Petegem, ...
Poultry Science, 103578, 2024
2024
Cryo-EM analysis of the malignant hyperthermia-causing T4826I mutant of ryanodine receptor 1 and its interplay with pharmacological agents
YS Chen, M García-Castañeda, PD Allen, F Van Petegem
Biophysical Journal 123 (3), 443a, 2024
2024
Propofol binding sites on ryanodine receptor 1
TT Joseph, W Bu, O Haji-Ghassemi, K Woll, GH Brannigan, ...
Biophysical Journal 123 (3), 534a, 2024
2024
Cryo-EM reveals binding of ryanodine receptors to drugs that are associated with muscle weakness
S Molinarolo, CR Valdivia, HH Valdivia, F Van Petegem
Biophysical Journal 123 (3), 534a, 2024
2024
Localising elements in single-particle reconstructions by REEL-EM: Reconstructed Electron Energy-Loss-Elemental Mapping
O Pfeil-Gardiner, HVD Rosa, D Riedel, YS Chen, D Lorks, P Kukelhan, ...
bioRxiv, 2024.01. 18.575858, 2024
2024
Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)
TT Joseph, W Bu, O Haji-Ghassemi, YS Chen, K Woll, PD Allen, ...
bioRxiv, 2024.01. 10.575040, 2024
2024
Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase
R Yoo, O Haji-Ghassemi, C McFarlane, J Xu, F Van Petegem
bioRxiv, 2023.10. 24.563811, 2023
2023
RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET
J Seflova, JA Schwarz, AN Smith, B Svensson, DJ Blackwell, TA Phillips, ...
ACS Chemical Biology 18 (10), 2290-2299, 2023
22023
Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives
S Cholak, JW Saville, X Zhu, AM Berezuk, KS Tuttle, O Haji-Ghassemi, ...
Structure 31 (7), 790-800. e4, 2023
52023
Electrophysiological Characterisation of Calcium Channel Mutant, Cav1. 2-R1586Q, Associated With Long QT Syndrome 8
A Dyrda, E Ingley, F van Petegem, L Hool
Heart, Lung and Circulation 32, S153-S154, 2023
2023
Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation
O Haji-Ghassemi, YS Chen, K Woll, GB Gurrola, CR Valdivia, W Cai, S Li, ...
Science Advances 9 (21), eadf4936, 2023
52023
PO-01-178 MAPPING OF PATHOGENIC VARIANT HOTSPOTS ON THE STRUCTURE OF RYANODINE RECEPTOR TYPE 2 DRIVES A RATIONAL DRUG DESIGN APPROACH FOR CATECHOLAMINERGIC POLYMORPHIC …
G Monaco, LM Kurzlechner, F Van Petegem, AP Landstrom
Heart Rhythm 20 (5), S155, 2023
2023
RNA Polymerase II transcription independent of TBP in murine embryonic stem cells
JZJ Kwan, TF Nguyen, AC Uzozie, MA Budzynski, J Cui, JMC Lee, ...
Elife 12, e83810, 2023
62023
Structural insights for the modulation of KCNQ1 channel by ML277
E Kyriakis, J Eldstrom, K Willegems, F Ataei, H Sahakyan, Y Dou, S Russo, ...
Biophysical Journal 122 (3), 21a, 2023
2023
Cryo-EM investigation of the subconductance state of ryanodine receptor calcium release channels induced by scorpion toxins
F Van Petegem, O Haji-Ghassemi, Y Chen, K Woll, CR Valdivia, ...
Biophysical Journal 122 (3), 164a, 2023
2023
Investigation of PKA interactions with cardiac voltage gated calcium channel and Rad GTPase
O Haji-Ghassemi, R Yoo, J Xu, C McFarlane, F Van Petegem
Biophysical Journal 122 (3), 480a-481a, 2023
2023
Allosteric Modulation of RyR1 with Nucleotide Analogs
S Cholak, J Saville, X Zhu, A Berezuk, O Haji-Ghassemi, K Tuttle, ...
PROTEIN SCIENCE 32, 2023
2023
RYR-1-related diseases international research workshop: from mechanisms to treatments Pittsburgh, PA, USA, 21-22 July 2022
TN O'Connor, LR van den Bersselaar, YS Chen, S Nicolau, B Simon, ...
32023
Structural and functional conservation of the activating Ca2+ binding site in inositol 1, 4.5-trisphosphate and ryanodine receptors
YS Chen, F Van Petegem
Cell Calcium 108, 102671, 2022
22022
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