关注
Christopher John Brown
Christopher John Brown
Principle Investigator
在 p53lab.a-star.edu.sg 的电子邮件经过验证
标题
引用次数
年份
Overcoming the cell membrane to target intracellular oncoproteins
CJ Brown, Y Li, K Sabapathy
Frontiers in Oncology 13, 1222095, 2023
2023
Further Characterization of Fungal Halogenase RadH and Its Homologs
GR Peh, GA Gunawan, T Tay, E Tiong, LL Tan, S Jiang, YL Goh, S Ye, ...
Biomolecules 13 (7), 1081, 2023
12023
A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays
SH Kasper, S Otten, B Squadroni, C Orr‐Terry, Y Kuang, L Mussallem, ...
Bioengineering & Translational Medicine, e10542, 2023
2023
Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
A Chandramohan, H Josien, T Yuen, R Duggal, D Spiegelberg, L Yan, ...
bioRxiv, 2023.02. 25.530030, 2023
12023
Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein
C Jelinska, S Kannan, Y Frosi, SR Ramlan, F Winnerdy, ...
bioRxiv, 2022.09. 25.508451, 2022
12022
P53 activator peptidomimetic macrocycles
P Aronica, CJ Brown, FJ Ferrer, CW Johannes, S Kannan, DP Lane, ...
US Patent App. 17/618,751, 2022
2022
Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex
Y Frosi, YC Lin, J Shimin, SR Ramlan, K Hew, AH Engman, A Pillai, ...
Nature communications 13 (1), 1-22, 2022
62022
Peptides and Compounds that Bind to Elongation Initiation Factor 4E
S Ng, CJ Brown
US Patent App. 17/436,118, 2022
2022
Molecular descriptors suggest stapling as a strategy for optimizing membrane permeability of cyclic peptides
J Li, S KANNAN, P ARONICA, C BROWN, A Partridge, C Verma
The Journal of Chemical Physics, 2022
2022
Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE)
Y Frosi, S Ng, YC Lin, S Jiang, R Ramlan, D Lama, C Verma, I Asial, ...
RSC Chemical Biology, 2022
12022
Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides
TJ Desai, B Habulihaz, JR Cannon, A Chandramohan, HYK Kaan, ...
Pharmaceutical research 38 (4), 735-736, 2021
2021
Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides (Mar, 10.1007/s11095-021-03005-z, 2021)
TJ Desai, B Habulihaz, JR Cannon, A Chandramohan, HYK Kaan, ...
PHARMACEUTICAL RESEARCH 38 (4), 735-736, 2021
2021
Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways
Y Frosi, S Jiang, SR Ramlan, KH Hew, AH Engman, A Pillai, YX Cheng, ...
12021
Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides
TJ Desai, B Habulihaz, JR Cannon, A Chandramohan, HYK Kaan, ...
Pharmaceutical research, 1-8, 2021
102021
NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay
A Peier, L Ge, N Boyer, J Frost, R Duggal, K Biswas, S Edmondson, ...
ACS Chemical Biology 16 (2), 293-309, 2021
362021
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling
S Lim, N Boyer, N Boo, C Huang, G Venkatachalam, YCA Juang, ...
Chemical Science, 2021
152021
Conformational ordering of intrinsically disordered peptides for targeting translation initiation
CJ Brown, CS Verma, DP Lane, D Lama
Biochimica et Biophysica Acta (BBA)-General Subjects 1865 (1), 129775, 2021
22021
Directed co-evolution of interacting protein–peptide pairs by compartmentalized two-hybrid replication (C2HR)
JW Siau, S Nonis, S Chee, LQ Koh, FJ Ferrer, CJ Brown, FJ Ghadessy
Nucleic acids research 48 (22), e128-e128, 2020
42020
Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2
ACL Mortensen, E Morin, CJ Brown, DP Lane, M Nestor
EJNMMI research 10 (1), 1-10, 2020
82020
Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
Y Frosi, SR Ramlan, CJ Brown
JoVE (Journal of Visualized Experiments), e60850, 2020
2020
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