| BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome KA Miller, DAC Walma, DM Pinkas, RS Tooze, JC Bufton, W Richardson, ... Journal of Medical Genetics 61 (5), 490-501, 2024 | 4 | 2024 |
| Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2 WJ Bradshaw, EC Kennedy, T Moreira, LA Smith, R Chalk, VL Katis, ... Structure 32 (4), 453-466. e6, 2024 | | 2024 |
| Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM FM Bashore, VL Katis, Y Du, A Sikdar, D Wang, WJ Bradshaw, KA Rygiel, ... Plos one 19 (2), e0293548, 2024 | 2 | 2024 |
| Structural basis of the mechanism and inhibition of a human ceramide synthase TC Pascoa, ACW Pike, CS Tautermann, G Chi, M Traub, A Quigley, ... bioRxiv, 2023.12. 02.569723, 2023 | 2 | 2023 |
| Structural characterization of human urea transporters UT-A and UT-B and their inhibition G Chi, L Dietz, H Tang, M Snee, A Scacioc, D Wang, G Mckinley, ... Science Advances 9 (39), eadg8229, 2023 | | 2023 |
| Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease AS Godoy, AM Nakamura, A Douangamath, Y Song, GD Noske, ... Nucleic Acids Research 51 (10), 5255-5270, 2023 | 11 | 2023 |
| An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition GD Noske, Y Song, RS Fernandes, R Chalk, H Elmassoudi, L Koekemoer, ... Nature Communications 14 (1), 1545, 2023 | 11 | 2023 |
| Reducing hyperglucagonaemia in type 2 diabetes using low‐dose glibenclamide: Results of the LEGEND‐A pilot study II Spiliotis, R Chalk, S Gough, P Rorsman Diabetes, Obesity & Metabolism 24 (8), 1671, 2022 | 7 | 2022 |
| Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells O Tietz, F Cortezon-Tamarit, R Chalk, S Able, KA Vallis Nature Chemistry 14 (3), 284-293, 2022 | 89 | 2022 |
| Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting R Chalk, WEP Greenland, T Moreira, J Coker, SMM Mukhopadhyay, ... Communications Biology 4 (1), 934, 2021 | 5 | 2021 |
| Structural insights into notum covalent inhibition Y Zhao, F Svensson, D Steadman, S Frew, A Monaghan, M Bictash, ... Journal of Medicinal Chemistry 64 (15), 11354-11363, 2021 | 10 | 2021 |
| A new paradigm for Prelamin A proteolytic processing by ZMPSTE24: the upstream SY^ LL cleavage occurs first and there is no CaaX processing by ZMPSTE24 L Nie, E Spear, TD Babatz, A Quigley, YY Dong, A Chu, B Rotty, R Chalk, ... bioRxiv, 2020.05. 13.093849, 2020 | 8 | 2020 |
| Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity C McClenaghan, Y Huang, Z Yan, TM Harter, CM Halabi, R Chalk, ... The Journal of clinical investigation 130 (3), 1116-1121, 2020 | 44 | 2020 |
| An 111 In-labelled bis-ruthenium (II) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells MR Gill, MG Walker, S Able, O Tietz, A Lakshminarayanan, R Anderson, ... Chemical science 11 (33), 8936-8944, 2020 | 13 | 2020 |
| Towards intracellular targeting: Cytosolic delivery using TAT-trimers O Tietz, R Chalk, KA Vallis Cancer Research 79 (13_Supplement), 3616-3616, 2019 | | 2019 |
| Electrospray Surface Charge Describes Protein Molecular Motion R Chalk, O Borkowska, KA Azeez, S Oerum, P Born, O Gileadi, ... bioRxiv, 571091, 2019 | 4 | 2019 |
| Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design YY Dong, H Wang, ACW Pike, SA Cochrane, S Hamedzadeh, ... Cell 175 (4), 1045-1058. e16, 2018 | 73 | 2018 |
| Structural basis for the regulation of human 5, 10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition DS Froese, J Kopec, E Rembeza, GA Bezerra, AE Oberholzer, ... Nature communications 9 (1), 2261, 2018 | 69 | 2018 |
| Tryptophan-mediated interactions between tristetraprolin and the CNOT9 subunit are required for CCR4-NOT deadenylase complex recruitment D Bulbrook, H Brazier, P Mahajan, M Kliszczak, O Fedorov, FP Marchese, ... Journal of molecular biology 430 (5), 722-736, 2018 | 43 | 2018 |
| Structural basis of human 5, 10-methylenetetrahydrofolate reductase (MTHFR) regulation by phosphorylation and S-adenosylmethionine inhibition DS Froese, J Kopec, E Rembeza, GA Bezerra, AE Oberholzer, ... bioRxiv, 271593, 2018 | 1 | 2018 |
