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Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy JH Chen, LT Nieman, M Spurrell, V Jorgji, L Elmelech, P Richieri, KH Xu, ... Nature Immunology 25 (4), 644-658, 2024 | 5 | 2024 |
Spatial organization and cellular composition of immunity hubs in human colorectal cancer MG Palshikar, M Spurrell, J Demaray, H Chen, S Engels, R Madhu, ... Cancer Research 84 (6_Supplement), 5492-5492, 2024 | | 2024 |
scRNAseq and TCR repertoire analysis identifies immune correlates of response to combined BRAF/MEK/PD1 inhibition in a phase 2 trial H Yao, V Jorgji, AL Tang, D Lieb, SX Chao, DJ Stein, M Spurrell, ... Cancer Research 84 (6_Supplement), 6555-6555, 2024 | | 2024 |
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Integrating spatial transcriptomics count data with Crescendo improves visualization and detection of spatial gene patterns N Millard, JH Chen, MG Palshikar, K Pelka, M Spurrell, C Price, J He, ... bioRxiv, 2024.03. 07.583997, 2024 | | 2024 |
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Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response JH Chen, LT Nieman, M Spurrell, V Jorgji, P Richieri, KH Xu, R Madhu, ... BioRxiv, 2023.04. 04.535379, 2023 | 16 | 2023 |
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Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial J Tian, JH Chen, SX Chao, K Pelka, M Giannakis, J Hess, K Burke, ... Nature medicine 29 (2), 458-466, 2023 | 62 | 2023 |
1242 altered interactions between circulating and tissue-resident Cd8 T cells with the Colonic mucosa define Checkpoint inhibitor colitis K Slowikowski, M Thomas, K Manakongtreecheep, P Sen, J Tantivit, ... Journal for ImmunoTherapy of Cancer 10 (Suppl 2), 2022 | 1 | 2022 |
Integrative single cell and spatial transcriptomics of colorectal cancer reveals multicellular functional units that support tumor progression I Avraham-Davidi, S Mages, J Klughammer, N Moriel, S Imada, M Hofree, ... BioRxiv, 2022.10. 02.508492, 2022 | 13 | 2022 |
Abstract LB003: Combined BRAF, MEK, and PD-1 inhibition in BRAFV600E colorectal cancer patients: Correlative studies from a phase 2 trial J Tian, JH Chen, SX Chao, K Pelka, V Jorgji, I Baiev, WB Bradford, ... Cancer Research 82 (12_Supplement), LB003-LB003, 2022 | 1 | 2022 |
A single-cell spatially resolved map of colorectal cancer identifies novel spatial relationships between cancer cells and the microenvironment C Price, JH Chen, K Pelka, S Chao, M Therrien, T Wiggin, N Fernandez, ... Cancer Research 82 (12_Supplement), 2030-2030, 2022 | 2 | 2022 |
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Listening in on multicellular communication in human tissue immunology JJ Albers, K Pelka Frontiers in Immunology 13, 884185, 2022 | 3 | 2022 |
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps B Chen, S Cherie’R, ET McKinley, AJ Simmons, MA Ramirez-Solano, ... Cell 184 (26), 6262-6280. e26, 2021 | 169 | 2021 |
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920 A single-cell spatially resolved MERFISH map of the colorectal tumor immune microenvironment C Price, J Chen, K Pelka, S Chao, J He, G Boland, G Emanuel, ... Journal for ImmunoTherapy of Cancer 9 (Suppl 2), 2021 | 3 | 2021 |