Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant A Traa, AA Tamez González, JM Van Raamsdonk GeroScience, 1-26, 2024 | | 2024 |
Overexpression of mitochondrial fission or mitochondrial fusion genes enhances resilience and extends longevity A Traa, A Keil, A AlOkda, S Jacob‐Tomas, AA Tamez González, S Zhu, ... Aging Cell, e14262, 2024 | 1 | 2024 |
Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions G Hajj-Boutros, A Faust, J Muscedere, P Kim, N Abumrad, S Chevalier, ... The Journals of Gerontology, Series A: Biological Sciences and Medical …, 2024 | | 2024 |
Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation A Tyshkovskiy, D Kholdina, K Ying, M Davitadze, A Molière, Y Tongu, ... bioRxiv, 2024.07. 04.601982, 2024 | | 2024 |
Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice JM Van Raamsdonk, HH Al-Shekaili, L Wagner, TW Bredy, L Chan, ... Aging and Disease 14 (6), 2249, 2023 | | 2023 |
The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response G Wang, R Laranjeiro, S LeValley, JM Van Raamsdonk, M Driscoll Free Radical Biology and Medicine 208, 771-779, 2023 | 1 | 2023 |
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension SK Soo, ZD Rudich, B Ko, A Moldakozhayev, A AlOkda, ... Ageing Research Reviews 88, 101941, 2023 | 20 | 2023 |
RNA sequencing of pooled samples effectively identifies differentially expressed genes B Ko, JM Van Raamsdonk Biology 12 (6), 812, 2023 | 7 | 2023 |
Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants A Traa, H Shields, A AlOkda, ZD Rudich, B Ko, JM Van Raamsdonk Frontiers in Aging 4, 1145198, 2023 | | 2023 |
Evolutionarily conserved role of thioredoxin systems in determining longevity A AlOkda, JM Van Raamsdonk Antioxidants 12 (4), 944, 2023 | 7 | 2023 |
Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms A Traa, SK Soo, A AlOkda, B Ko, CE Rocheleau, JM Van Raamsdonk Aging cell 22 (3), e13762, 2023 | 3 | 2023 |
Genetic basis of enhanced stress resistance in long‐lived mutants highlights key role of innate immunity in determining longevity SK Soo, A Traa, ZD Rudich, A Moldakozhayev, M Mistry, ... Aging Cell 22 (2), e13740, 2023 | 15 | 2023 |
Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics JC Campos, LH Marchesi Bozi, B Krum, LR Grassmann Bechara, ... Proceedings of the National Academy of Sciences 120 (2), e2204750120, 2023 | 39 | 2023 |
Overexpression of mitochondrial fusion genes enhances resilience and extends longevity A Traa, A Keil, Z Rudich, S Zhu, J Van Raamsdonk bioRxiv, 2023.10. 24.563703, 2023 | | 2023 |
The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan İ Meraş, L Chotard, T Liontis, Z Ratemi, B Wiles, JH Seo, ... PLoS Genetics 18 (8), e1010328, 2022 | 2 | 2022 |
Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants N Harris-Gauthier, A Traa, A AlOkda, A Moldakozhayev, U Anglas, ... Redox biology 53, 102335, 2022 | 17 | 2022 |
Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models LL Chan, A Hill, G Lu, J Van Raamsdonk, R Gascoyne, MR Hayden, ... Journal of Huntington's Disease 11 (4), 383-389, 2022 | | 2022 |
Effect of DMSO on lifespan and physiology in C. elegans: Implications for use of DMSO as a solvent for compound delivery A AlOkda, JM Van Raamsdonk microPublication Biology 2022, 2022 | 10 | 2022 |
Identification of novel therapeutic targets for polyglutamine diseases that target mitochondrial fragmentation A Traa, E Machiela, PD Rudich, SK Soo, MM Senchuk, ... International journal of molecular sciences 22 (24), 13447, 2021 | 12 | 2021 |
Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling JC Campos, Z Wu, PD Rudich, SK Soo, M Mistry, JCB Ferreira, ... EMBO reports 22 (12), e52964, 2021 | 35 | 2021 |