| The chemokine CXCL14 is a novel early prognostic biomarker for poor outcome in acetaminophen-induced acute liver failure DS Umbaugh, NT Nguyen, SC Curry, JA Rule, WM Lee, A Ramachandran, ... Hepatology 79 (6), 1352-1364, 2024 | 3 | 2024 |
| The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration DS Umbaugh, NT Nguyen, SH Smith, A Ramachandran, H Jaeschke Toxicology 504, 153804, 2024 | 1 | 2024 |
| Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight DS Umbaugh, H Jaeschke Expert Review of Clinical Pharmacology 17 (2), 143-155, 2024 | 1 | 2024 |
| Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose G Sanchez-Guerrero, DS Umbaugh, AA Ramachandran, A Artigues, ... Livers 4 (1), 15-30, 2023 | | 2023 |
| Hepatocyte senescence is initiated through a Klf6-p21 mechanism which mediates the production of Cxcl14, a novel prognostic biomarker of acute liver failure D Umbaugh, N Nguyen, GS Guerrero, C Villanueva, B Hagenbuch, ... Journal of Pharmacology and Experimental Therapeutics 385 (S3), 2023 | 2 | 2023 |
| Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice NT Nguyen, DS Umbaugh, S Smith, OB Adelusi, G Sanchez-Guerrero, ... Archives of toxicology 97 (5), 1397-1412, 2023 | 19 | 2023 |
| Role of pyroptosis in acetaminophen-induced hepatotoxicity H Jaeschke, DS Umbaugh, A Ramachandran Livers 2 (4), 425-435, 2022 | 3 | 2022 |
| Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts DS Umbaugh, RP Soder, NT Nguyen, O Adelusi, DR Robarts, ... Archives of toxicology 96 (12), 3315-3329, 2022 | 6 | 2022 |
| Neuronal inflammation is associated with changes in epidermal innervation in high fat fed mice DS Umbaugh, JC Maciejewski, JS Wooten, BL Guilford Frontiers in Physiology 13, 891550, 2022 | 2 | 2022 |
| Recovered hepatocytes promote macrophage apoptosis through CXCR4 after acetaminophen-induced liver injury in mice NT Nguyen, DS Umbaugh, EL Huang, OB Adelusi, G Sanchez Guerrero, ... Toxicological Sciences 188 (2), 248-260, 2022 | 3 | 2022 |
| Protection against acetaminophen-induced liver injury with MG53: Muscle-liver axis and necroptosis H Jaeschke, DS Umbaugh Journal of Hepatology 77 (2), 560-562, 2022 | 2 | 2022 |
| Novel Somatostatin Receptor-4 Agonist SM-I-26 Mitigates Lipopolysaccharide-Induced Inflammatory Gene Expression in Microglia A Silwal, A House, K Sandoval, S Vijeth, D Umbaugh, A Crider, ... Neurochemical research 47 (3), 768-780, 2022 | 2 | 2022 |
| Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice NT Nguyen, DS Umbaugh, G Sanchez-Guerrero, A Ramachandran, ... Archives of toxicology, 1-16, 2022 | 35 | 2022 |
| The effects of voluntary wheel running during weight-loss on biomarkers of hepatic lipid metabolism and inflammation in C57Bl/6J mice JS Wooten, KE Poole, MP Harris, BL Guilford, ML Schaller, D Umbaugh, ... Current Research in Physiology 5, 63-72, 2022 | 4 | 2022 |
| Regulation of liver regeneration by hepatocyte O-GlcNAcylation in mice DR Robarts, SR McGreal, DS Umbaugh, WS Parkes, M Kotulkar, ... Cellular and molecular gastroenterology and hepatology 13 (5), 1510-1529, 2022 | 22 | 2022 |
| Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls H Jaeschke, OB Adelusi, JY Akakpo, NT Nguyen, G Sanchez-Guerrero, ... Acta Pharmaceutica Sinica B 11 (12), 3740-3755, 2021 | 57 | 2021 |
| Spatial reconstruction of the early hepatic transcriptomic landscape after an acetaminophen overdose using single-cell RNA-sequencing DS Umbaugh, A Ramachandran, H Jaeschke Toxicological Sciences 182 (2), 327-345, 2021 | 23 | 2021 |
| Mitochondrial dynamics in drug-induced liver injury A Ramachandran, DS Umbaugh, H Jaeschke Livers 1 (3), 102-115, 2021 | 19 | 2021 |
| Biomarkers of drug-induced liver injury: A mechanistic perspective through acetaminophen hepatotoxicity DS Umbaugh, H Jaeschke Expert review of gastroenterology & hepatology 15 (4), 363-375, 2021 | 21 | 2021 |
| Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice NT Nguyen, K Du, JY Akakpo, DS Umbaugh, H Jaeschke, ... Toxicology letters 338, 21-31, 2021 | 43 | 2021 |
Hartmut JaeschkeUniversity Distinguished Professor and Chair, University of Kansas Medical Center在 kumc.edu 的电子邮件经过验证
Hartmut JaeschkeUniversity Distinguished Professor and Chair, University of Kansas Medical Center在 kumc.edu 的电子邮件经过验证