关注
SAMARASINGHE K.T.G
SAMARASINGHE K.T.G
Postdoctoral Associate, Yale University
在 yale.edu 的电子邮件经过验证
标题
引用次数
年份
OligoTRAFTACs: a generalizable method for transcription factor degradation
KTG Samarasinghe, E An, MA Genuth, L Chu, SA Holley, CM Crews
RSC Chemical Biology 3 (9), 1144-1153, 2022
242022
Identification and quantification of glutathionylated cysteines under ischemic stress
M Yapa Abeywardana, KTG Samarasinghe, D Munkanatta Godage, ...
Journal of proteome research 20 (9), 4529-4542, 2021
72021
Targeted protein degradation: A promise for undruggable proteins
KTG Samarasinghe, CM Crews
Cell chemical biology 28 (7), 934-951, 2021
1552021
Targeted degradation of transcription factors by TRAFTACs: transcription factor targeting chimeras
KTG Samarasinghe, S Jaime-Figueroa, M Burgess, DA Nalawansha, ...
Cell chemical biology 28 (5), 648-661. e5, 2021
1182021
Mutant-selective degradation by BRAF-targeting PROTACs
S Alabi, S Jaime-Figueroa, Z Yao, Y Gao, J Hines, KTG Samarasinghe, ...
Nature communications 12 (1), 920, 2021
1002021
Double-barreled CRISPR technology as a novel treatment strategy for COVID-19
DA Nalawansha, KTG Samarasinghe
ACS Pharmacology & Translational Science 3 (5), 790-800, 2020
262020
Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable photoPROTACs
EC Patrick Pfaff, Kusal T. G. Samarasinghe, Craig M. Crews
ACS Central Science, 2019
225*2019
Addressing kinase-independent functions of Fak via PROTAC-mediated degradation
PM Cromm, KTG Samarasinghe, J Hines, CM Crews
Journal of the American Chemical Society 140 (49), 17019-17026, 2018
2412018
SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
DNP Munkanatta Godage, GC VanHecke, KTG Samarasinghe, HZ Feng, ...
Nature communications 9 (1), 4341, 2018
322018
Development Of Chemical Tools To Investigate Protein S-Glutathionylation In Response To Metabolic Alteration
KTG Samarasinghe
2017
A clickable glutathione approach for identification of protein glutathionylation in response to glucose metabolism
KTG Samarasinghe, DNPM Godage, Y Zhou, FT Ndombera, ...
Molecular BioSystems 12 (8), 2471-2480, 2016
352016
Clickable glutathione using tetrazine-alkene bioorthogonal chemistry for detecting protein glutathionylation
DN Kekulandara, KTG Samarasinghe, DNPM Godage, YH Ahn
Organic & biomolecular chemistry 14 (46), 10886-10893, 2016
272016
Synthesizing clickable glutathione by glutathione synthetase mutant for detecting protein glutathionylation
KTG Samarasinghe, YH Ahn
Synlett 26 (03), 285-293, 2015
142015
Metabolic synthesis of clickable glutathione for chemoselective detection of glutathionylation
KTG Samarasinghe, DNP Munkanatta Godage, GC VanHecke, YH Ahn
Journal of the American Chemical Society 136 (33), 11566-11569, 2014
582014
Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation
Y Zhang, S Dayalan Naidu, K Samarasinghe, GC Van Hecke, A Pheely, ...
British journal of cancer 110 (1), 71-82, 2014
322014
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