| Greedy reduction of Bacillus subtilis genome yields emergent phenotypes E Dervyn, AG Planson, K Tanaka, V Chubukov, C Guérin, S Dérozier, ... BACELL2023, 2023 | | 2023 |
| Greedy reduction of Bacillus subtilis genome yields emergent phenotypes of high resistance to a DNA damaging agent and low evolvability E Dervyn, AG Planson, K Tanaka, V Chubukov, C Guérin, S Derozier, ... Nucleic Acids Research 51 (6), 2974-2992, 2023 | 8 | 2023 |
| Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy MAE Rab, J Bos, BA van Oirschot, S van Straaten, PA Kosinski, ... Blood, The Journal of the American Society of Hematology 137 (21), 2997-3001, 2021 | 31 | 2021 |
| Itaconate confers tolerance to late NLRP3 inflammasome activation M Bambouskova, L Potuckova, T Paulenda, M Kerndl, DA Mogilenko, ... Cell reports 34 (10), 2021 | 132 | 2021 |
| AG-348 (mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and adenosine triphosphate levels over a broad … MAE Rab, BA Van Oirschot, PA Kosinski, J Hixon, K Johnson, ... Haematologica 106 (1), 238, 2021 | 58 | 2021 |
| Selective vulnerability to pyrimidine starvation in hematologic malignancies revealed by AG-636, a novel clinical-stage inhibitor of dihydroorotate dehydrogenase G McDonald, V Chubukov, J Coco, K Truskowski, R Narayanaswamy, ... Molecular Cancer Therapeutics 19 (12), 2502-2515, 2020 | 20 | 2020 |
| > Corna-An Open Source Python Tool For Natural Abundance Correction In Isotope Tracer Experiments R Raaisa, S Lathwal, V Chubukov, RG Kibbey, AK Jha bioRxiv, 2020.09. 19.304741, 2020 | 2 | 2020 |
| Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages A Swain, M Bambouskova, H Kim, PS Andhey, D Duncan, K Auclair, ... Nature metabolism 2 (7), 594-602, 2020 | 196 | 2020 |
| Utilization of Stable Isotope Tail-Vein Infusion to Assess Glutamine Utilization by Physiologically Activated CD8+ T cells in vivo EH Ma, MJ Verway, DG Roy, M Steadman, T Griss, B Sambroska, ... The Journal of Immunology 204 (1_Supplement), 155.2-155.2, 2020 | | 2020 |
| Comparative evaluation of metabolic, electrophilic, and immunologic effects of itaconate and its ester derivatives on macrophage activation AC Swain, M Bambouskova, H Kim, D Duncan, K Auclair, V Chubukov, ... The Journal of Immunology 204 (1_Supplement), 73.1-73.1, 2020 | | 2020 |
| Methionine metabolism shapes T helper cell responses through regulation of epigenetic reprogramming DG Roy, J Chen, V Mamane, EH Ma, BM Muhire, RD Sheldon, ... Cell metabolism 31 (2), 250-266. e9, 2020 | 226 | 2020 |
| Metabolic profiling using stable isotope tracing reveals distinct patterns of glucose utilization by physiologically activated CD8+ T cells EH Ma, MJ Verway, RM Johnson, DG Roy, M Steadman, S Hayes, ... Immunity 51 (5), 856-870. e5, 2019 | 308 | 2019 |
| Hematologic malignancies exhibit selective vulnerability to inhibition of de novo pyrimidine biosynthesis by AG-636, a novel inhibitor of dihydroorotate dehydrogenase in phase … D Ulanet, V Chubukov, J Coco, G McDonald, M Steadman, ... Blood 134, 1570, 2019 | 1 | 2019 |
| A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition CE Mahoney, D Pirman, V Chubukov, T Sleger, S Hayes, ZP Fan, ... Nature communications 10 (1), 96, 2019 | 71 | 2019 |
| Improving membrane protein expression and function using genomic edits HM Jensen, T Eng, V Chubukov, RA Herbert, A Mukhopadhyay Scientific reports 7 (1), 13030, 2017 | 45 | 2017 |
| EX VIVO TREATMENT OF RED BLOOD CELLS FROM 15 PYRUVATE KINASE (PK)-DEFICIENT PATIENTS WITH AG-348, AN ALLOSTERIC ACTIVATOR OF PK-R, INCREASES ENZYMATIC ACTIVITY, PROTEIN … B van Oirschot, PA Kosinski, J Hixon, K Johnson, V Chubukov, L Dang, ... HAEMATOLOGICA 102, 241-242, 2017 | | 2017 |
| Metabolic constraints on the evolution of antibiotic resistance M Zampieri, T Enke, V Chubukov, V Ricci, L Piddock, U Sauer Molecular Systems Biology 13 (3), 917, 2017 | 157 | 2017 |
| Engineering glucose metabolism of Escherichia coli under nitrogen starvation V Chubukov, JJ Desmarais, G Wang, LJG Chan, EEK Baidoo, CJ Petzold, ... NPJ systems biology and applications 3 (1), 1-7, 2017 | 45 | 2017 |
| Characterization of metabolic response to AG-348, an allosteric activator of red cell pyruvate kinase, in healthy volunteers and pyruvate kinase deficiency patients V Chubukov, K Johnson, PA Kosinski, M Clasquin, A Jha, H Kim, ... Blood 128 (22), 2452, 2016 | 10 | 2016 |
| Synthetic and systems biology for microbial production of commodity chemicals V Chubukov, A Mukhopadhyay, CJ Petzold, JD Keasling, HG Martín NPJ systems biology and applications 2 (1), 1-11, 2016 | 234 | 2016 |
