" Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. GB Henderson, P Ulrich, AH Fairlamb, I Rosenberg, M Pereira, M Sela, ... Proceedings of the National Academy of Sciences 85 (15), 5374-5378, 1988 | 250 | 1988 |
[Opening Lecture]–Natural products and drug discovery for tropical diseases–successes, failures and lessons learned AH Fairlamb Planta Medica 79 (13), L1, 2013 | | 2013 |
7.2 FROM GENOME TO DISCOVERY IN LEISHMANIA: RECOMMENDATIONS FOR THE DEVELOPMENT OF DRUGS, VACCINES AND DIAGNOSTICS D Zilberstein, K Stuart, A Fairlamb | | |
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi C Fersing, C Boudot, C Castera-Ducros, E Pinault, S Hutter, ... European Journal of Medicinal Chemistry 202, 112558, 2020 | 19 | 2020 |
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl) imidazo [1, 2-a] pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases C Fersing, C Boudot, J Pedron, S Hutter, N Primas, C Castera-Ducros, ... European journal of medicinal chemistry 157, 115-126, 2018 | 20 | 2018 |
8-Methoxy-naphtho [2, 3-b] thiophen-4, 9-quinone, a non-competitive inhibitor of trypanothione reductase CL Zani, AH Fairlamb Memorias do Instituto Oswaldo Cruz 98, 565-568, 2003 | 31 | 2003 |
A 7.1 kb linear DNA molecule of Theileria parva has scrambled rDNA sequences and open reading frames for mitochondrially encoded proteins. A Kairo, AH Fairlamb, E Gobright, V Nene The EMBO journal 13 (4), 898-905, 1994 | 100 | 1994 |
A comparative study of methylglyoxal metabolism in trypanosomatids N Greig, S Wyllie, S Patterson, AH Fairlamb The FEBS journal 276 (2), 376-386, 2009 | 83 | 2009 |
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major J König, AH Fairlamb The FEBS journal 274 (21), 5643-5658, 2007 | 56 | 2007 |
A comparison of two independently determined structures of trypanothione reductase from Crithidia fasciculata CS Bond, AH Fairlamb, WN Hunter Acta Crystallographica Section D: Biological Crystallography 51 (4), 567-574, 1995 | 2 | 1995 |
A high-throughput in vitro screen to identify inhibitors of the trypanosoma brucei trypananthione synthethase activity M Kramer, L Torrie, M Booker, D Spinks, RH Barker, S Oza, M Harris, ... American Journal of Tropical Medicine and Hygiene 83 (5 (Suppl.)), 323-323, 2010 | | 2010 |
A MULTI-STAGE PRECLINICAL CANDIDATE FOR THE POTENTIAL TREATMENT OF MALARIA NR Norcross, B Baragana, I Hallyburton, R Grimaldi, M Osuna-Cabello, ... AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 93 (4), 247-247, 2015 | | 2015 |
A new expression vector for Crithidia fasciculata and Leishmania E Tetaud, I Lecuix, T Sheldrake, T Baltz, AH Fairlamb Molecular and biochemical parasitology 120 (2), 195-204, 2002 | 85 | 2002 |
A novel multiple-stage antimalarial agent that inhibits protein synthesis B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ... Nature 522 (7556), 315-320, 2015 | 445 | 2015 |
A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism AJ Roberts, J Dunne, P Scullion, S Norval, AH Fairlamb Biochemical Journal 475 (16), 2593-2610, 2018 | 14 | 2018 |
A simple magnetic method for the purification of malarial pigment AH Fairlamb, F Paul, DC Warhurst Molecular and biochemical parasitology 12 (3), 307-312, 1984 | 23 | 1984 |
A single enzyme catalyses formation of trypanothione from glutathione and spermidine in Trypanosoma cruzi SL Oza, E Tetaud, MR Ariyanayagam, SS Warnon, AH Fairlamb Journal of Biological Chemistry 277 (39), 35853-35861, 2002 | 152 | 2002 |
A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes M De Rycker, S O'Neill, D Joshi, L Campbell, DW Gray, AH Fairlamb PLoS neglected tropical diseases 6 (11), e1932, 2012 | 35 | 2012 |
A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major TJ Vickers, N Greig, AH Fairlamb Proceedings of the National Academy of Sciences 101 (36), 13186-13191, 2004 | 102 | 2004 |
Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania S Wyllie, AJ Roberts, S Norval, S Patterson, BJ Foth, M Berriman, ... PLoS pathogens 12 (11), e1005971, 2016 | 85 | 2016 |