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Alan H Fairlamb
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引用次数
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" Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.
GB Henderson, P Ulrich, AH Fairlamb, I Rosenberg, M Pereira, M Sela, ...
Proceedings of the National Academy of Sciences 85 (15), 5374-5378, 1988
2501988
[Opening Lecture]–Natural products and drug discovery for tropical diseases–successes, failures and lessons learned
AH Fairlamb
Planta Medica 79 (13), L1, 2013
2013
7.2 FROM GENOME TO DISCOVERY IN LEISHMANIA: RECOMMENDATIONS FOR THE DEVELOPMENT OF DRUGS, VACCINES AND DIAGNOSTICS
D Zilberstein, K Stuart, A Fairlamb
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi
C Fersing, C Boudot, C Castera-Ducros, E Pinault, S Hutter, ...
European Journal of Medicinal Chemistry 202, 112558, 2020
192020
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl) imidazo [1, 2-a] pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases
C Fersing, C Boudot, J Pedron, S Hutter, N Primas, C Castera-Ducros, ...
European journal of medicinal chemistry 157, 115-126, 2018
202018
8-Methoxy-naphtho [2, 3-b] thiophen-4, 9-quinone, a non-competitive inhibitor of trypanothione reductase
CL Zani, AH Fairlamb
Memorias do Instituto Oswaldo Cruz 98, 565-568, 2003
312003
A 7.1 kb linear DNA molecule of Theileria parva has scrambled rDNA sequences and open reading frames for mitochondrially encoded proteins.
A Kairo, AH Fairlamb, E Gobright, V Nene
The EMBO journal 13 (4), 898-905, 1994
1001994
A comparative study of methylglyoxal metabolism in trypanosomatids
N Greig, S Wyllie, S Patterson, AH Fairlamb
The FEBS journal 276 (2), 376-386, 2009
832009
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major
J König, AH Fairlamb
The FEBS journal 274 (21), 5643-5658, 2007
562007
A comparison of two independently determined structures of trypanothione reductase from Crithidia fasciculata
CS Bond, AH Fairlamb, WN Hunter
Acta Crystallographica Section D: Biological Crystallography 51 (4), 567-574, 1995
21995
A high-throughput in vitro screen to identify inhibitors of the trypanosoma brucei trypananthione synthethase activity
M Kramer, L Torrie, M Booker, D Spinks, RH Barker, S Oza, M Harris, ...
American Journal of Tropical Medicine and Hygiene 83 (5 (Suppl.)), 323-323, 2010
2010
A MULTI-STAGE PRECLINICAL CANDIDATE FOR THE POTENTIAL TREATMENT OF MALARIA
NR Norcross, B Baragana, I Hallyburton, R Grimaldi, M Osuna-Cabello, ...
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 93 (4), 247-247, 2015
2015
A new expression vector for Crithidia fasciculata and Leishmania
E Tetaud, I Lecuix, T Sheldrake, T Baltz, AH Fairlamb
Molecular and biochemical parasitology 120 (2), 195-204, 2002
852002
A novel multiple-stage antimalarial agent that inhibits protein synthesis
B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ...
Nature 522 (7556), 315-320, 2015
4452015
A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism
AJ Roberts, J Dunne, P Scullion, S Norval, AH Fairlamb
Biochemical Journal 475 (16), 2593-2610, 2018
142018
A simple magnetic method for the purification of malarial pigment
AH Fairlamb, F Paul, DC Warhurst
Molecular and biochemical parasitology 12 (3), 307-312, 1984
231984
A single enzyme catalyses formation of trypanothione from glutathione and spermidine in Trypanosoma cruzi
SL Oza, E Tetaud, MR Ariyanayagam, SS Warnon, AH Fairlamb
Journal of Biological Chemistry 277 (39), 35853-35861, 2002
1522002
A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes
M De Rycker, S O'Neill, D Joshi, L Campbell, DW Gray, AH Fairlamb
PLoS neglected tropical diseases 6 (11), e1932, 2012
352012
A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major
TJ Vickers, N Greig, AH Fairlamb
Proceedings of the National Academy of Sciences 101 (36), 13186-13191, 2004
1022004
Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania
S Wyllie, AJ Roberts, S Norval, S Patterson, BJ Foth, M Berriman, ...
PLoS pathogens 12 (11), e1005971, 2016
852016
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