“Getting the Dose Right”—Revisiting the Topic With Focus on Biologic Agents DR Mould, RN Upton Clinical Pharmacology & Therapeutics, 2024 | | 2024 |
3D printed bilayer mucoadhesive buccal film of estradiol: Impact of design on film properties, release kinetics and predicted in vivo performance S Abdella, F Afinjuomo, Y Song, R Upton, S Garg International Journal of Pharmaceutics 628, 122324, 2022 | 12 | 2022 |
3D Printing of thermo-sensitive drugs S Abdella, SH Youssef, F Afinjuomo, Y Song, P Fouladian, R Upton, ... Pharmaceutics 13 (9), 1524, 2021 | 32 | 2021 |
3D Printing of Thermo-Sensitive Drugs. Pharmaceutics 2021, 13, 1524 S Abdella, SH Youssef, F Afinjuomo, Y Song, P Fouladian, R Upton, ... s Note: MDPI stays neu-tral with regard to jurisdictional claims in …, 2021 | 1 | 2021 |
A comparison of pharmacokinetic/pharmacodynamic versus mass-balance measurement of brain concentrations of intravenous anesthetics in sheep LJ Voss, G Ludbrook, C Grant, R Upton, JW Sleigh Anesthesia & Analgesia 104 (6), 1440-1446, 2007 | 22 | 2007 |
A comparison of the effects of general and spinal anaesthesia on chlormethiazole kinetics in the chronically catheterized sheep WB Runciman, AH Ilsley, LE Mather Clinical and Experimental Pharmacology and Physiology 9 (4), 1982 | 1 | 1982 |
A comparison of the effects of norepinephrine, epinephrine, and dopamine on cerebral blood flow and oxygen utilisation JA Myburgh, RN Upton, C Grant, A Martinez Intracranial Pressure and Neuromonitoring in Brain Injury: Proceedings of …, 1998 | 54 | 1998 |
A comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep RN Upton, AM Martinez, C Grant Anesthesiology 112 (1), 848, 2010 | 65 | 2010 |
A compartmental analysis of the pharmacokinetics of propofol in sheep GL Ludbrook, RN Upton, C Grant, A Martinez Journal of pharmacokinetics and biopharmaceutics 27, 329-338, 1999 | 16 | 1999 |
A descriptive tool to characterize nonlinear kinetics, with applications to meperidine and lidocaine JM Gries, R Upton, YF Huang, D Verotta Journal of pharmaceutical sciences 85 (4), 362-368, 1996 | 5 | 1996 |
A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems RN Upton, AM Martinez, C Grant British journal of pharmacology 155 (1), 52-61, 2008 | 51 | 2008 |
A method for frequent measurement of sedation and analgesia in sheep using the response to a ramped electrical stimulus G Ludbrook, C Grant, R Upton, C Penhall Journal of pharmacological and toxicological methods 33 (1), 17-22, 1995 | 29 | 1995 |
A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation GL Ludbrook, PE Macintyre, H Douglas, L Ong, RN Upton Anaesthesia 56 (8), 739-744, 2001 | 11 | 2001 |
A model of the first pass passage of drugs from iv injection site to the heart--parameter estimates for lignocaine in the sheep. RN Upton British journal of anaesthesia 77 (6), 764-772, 1996 | 36 | 1996 |
A model of the kinetics and dynamics of induction of anaesthesia in sheep: variable estimation for thiopental and comparison with propofol. RN Upton, GL Ludbrook British journal of anaesthesia 82 (6), 890-899, 1999 | 46 | 1999 |
A model‐based evaluation of single metrics for discriminating changes in rheumatoid arthritis disease activity J Wojciechowski, MD Wiese, SM Proudman, DJR Foster, RN Upton British Journal of Clinical Pharmacology 81 (6), 1046-1057, 2016 | | 2016 |
A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia AE Olesen, R Upton, DJR Foster, C Staahl, LL Christrup, L Arendt-Nielsen, ... Clinical pharmacokinetics 49, 817-827, 2010 | 31 | 2010 |
A pharmacokinetic model for L‐carnitine in patients receiving haemodialysis G Fornasini, RN Upton, AM Evans British journal of clinical pharmacology 64 (3), 335-345, 2007 | 41 | 2007 |
A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables RN Upton, GL Ludbrook British journal of anaesthesia 79 (4), 497-504, 1997 | 82 | 1997 |
A physiological model of induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirements. GL Ludbrook, RN Upton British journal of anaesthesia 79 (4), 505-513, 1997 | 96 | 1997 |