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Richard Upton
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“Getting the Dose Right”—Revisiting the Topic With Focus on Biologic Agents
DR Mould, RN Upton
Clinical Pharmacology & Therapeutics, 2024
2024
3D printed bilayer mucoadhesive buccal film of estradiol: Impact of design on film properties, release kinetics and predicted in vivo performance
S Abdella, F Afinjuomo, Y Song, R Upton, S Garg
International Journal of Pharmaceutics 628, 122324, 2022
122022
3D Printing of thermo-sensitive drugs
S Abdella, SH Youssef, F Afinjuomo, Y Song, P Fouladian, R Upton, ...
Pharmaceutics 13 (9), 1524, 2021
322021
3D Printing of Thermo-Sensitive Drugs. Pharmaceutics 2021, 13, 1524
S Abdella, SH Youssef, F Afinjuomo, Y Song, P Fouladian, R Upton, ...
s Note: MDPI stays neu-tral with regard to jurisdictional claims in …, 2021
12021
A comparison of pharmacokinetic/pharmacodynamic versus mass-balance measurement of brain concentrations of intravenous anesthetics in sheep
LJ Voss, G Ludbrook, C Grant, R Upton, JW Sleigh
Anesthesia & Analgesia 104 (6), 1440-1446, 2007
222007
A comparison of the effects of general and spinal anaesthesia on chlormethiazole kinetics in the chronically catheterized sheep
WB Runciman, AH Ilsley, LE Mather
Clinical and Experimental Pharmacology and Physiology 9 (4), 1982
11982
A comparison of the effects of norepinephrine, epinephrine, and dopamine on cerebral blood flow and oxygen utilisation
JA Myburgh, RN Upton, C Grant, A Martinez
Intracranial Pressure and Neuromonitoring in Brain Injury: Proceedings of …, 1998
541998
A comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep
RN Upton, AM Martinez, C Grant
Anesthesiology 112 (1), 848, 2010
652010
A compartmental analysis of the pharmacokinetics of propofol in sheep
GL Ludbrook, RN Upton, C Grant, A Martinez
Journal of pharmacokinetics and biopharmaceutics 27, 329-338, 1999
161999
A descriptive tool to characterize nonlinear kinetics, with applications to meperidine and lidocaine
JM Gries, R Upton, YF Huang, D Verotta
Journal of pharmaceutical sciences 85 (4), 362-368, 1996
51996
A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems
RN Upton, AM Martinez, C Grant
British journal of pharmacology 155 (1), 52-61, 2008
512008
A method for frequent measurement of sedation and analgesia in sheep using the response to a ramped electrical stimulus
G Ludbrook, C Grant, R Upton, C Penhall
Journal of pharmacological and toxicological methods 33 (1), 17-22, 1995
291995
A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation
GL Ludbrook, PE Macintyre, H Douglas, L Ong, RN Upton
Anaesthesia 56 (8), 739-744, 2001
112001
A model of the first pass passage of drugs from iv injection site to the heart--parameter estimates for lignocaine in the sheep.
RN Upton
British journal of anaesthesia 77 (6), 764-772, 1996
361996
A model of the kinetics and dynamics of induction of anaesthesia in sheep: variable estimation for thiopental and comparison with propofol.
RN Upton, GL Ludbrook
British journal of anaesthesia 82 (6), 890-899, 1999
461999
A model‐based evaluation of single metrics for discriminating changes in rheumatoid arthritis disease activity
J Wojciechowski, MD Wiese, SM Proudman, DJR Foster, RN Upton
British Journal of Clinical Pharmacology 81 (6), 1046-1057, 2016
2016
A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia
AE Olesen, R Upton, DJR Foster, C Staahl, LL Christrup, L Arendt-Nielsen, ...
Clinical pharmacokinetics 49, 817-827, 2010
312010
A pharmacokinetic model for L‐carnitine in patients receiving haemodialysis
G Fornasini, RN Upton, AM Evans
British journal of clinical pharmacology 64 (3), 335-345, 2007
412007
A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables
RN Upton, GL Ludbrook
British journal of anaesthesia 79 (4), 497-504, 1997
821997
A physiological model of induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirements.
GL Ludbrook, RN Upton
British journal of anaesthesia 79 (4), 505-513, 1997
961997
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