关注
Christopher John Brown
Christopher John Brown
Principle Investigator
在 p53lab.a-star.edu.sg 的电子邮件经过验证
标题
引用次数
年份
159 Stapled-peptides targeting the protein-binding interface of eukaryotic Translation Initiation Factor 4E (eIF4E) protein
D Lama, ST Quah, CJ Brown, DP Lane, CS Verma
Journal of Biomolecular Structure and Dynamics 33 (sup1), 102-103, 2015
42015
41 Applications of the inhibition of Mdm2 function in Cancer Therapy
D Lane, C Brown, CF Cheok, C Verma
Ejc Supplements 7 (8), 22-23, 2010
2010
A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays
SH Kasper, S Otten, B Squadroni, C Orr‐Terry, Y Kuang, L Mussallem, ...
Bioengineering & Translational Medicine, e10542, 2023
2023
Assessing the efficacy of Mdm2/Mdm4-inhibiting stapled peptides using cellular thermal shift assays
BX Tan, CJ Brown, FJ Ferrer, TY Yuen, ST Quah, BH Chan, AE Jansson, ...
Scientific reports 5 (1), 1-9, 2015
532015
Assessing the efficacy of Mdm2/Mdm4-inhibiting stapled peptides using cellular thermal shift assays
BX Tan, CJ Brown, FJ Ferrer, TY Yuen, ST Quah, BH Chan, AE Jansson, ...
Scientific reports 5 (1), 12116, 2015
532015
Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides
SJ Wei, S Chee, L Yurlova, D Lane, C Verma, C Brown, F Ghadessy
Oncotarget 7 (22), 32232, 2016
202016
Awakening guardian angels: drugging the p53 pathway
CJ Brown, S Lain, CS Verma, AR Fersht, DP Lane
Nature Reviews Cancer 9 (12), 862-873, 2009
10952009
Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design
YS Tan, J Reeks, CJ Brown, D Thean, FJ Ferrer Gago, TY Yuen, ETL Goh, ...
The journal of physical chemistry letters 7 (17), 3452-3457, 2016
452016
Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by nutlin-3
G Funston, W Goh, SJ Wei, QS Tng, C Brown, LJ Tong, C Verma, D Lane, ...
PLoS One 7 (8), e42642, 2012
192012
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)
S Lim, R Khoo, KM Peh, J Teo, SC Chang, S Ng, GL Beilhartz, RA Melnyk, ...
Proceedings of the National Academy of Sciences 117 (11), 5791-5800, 2020
852020
bioPROTACs as versatile modulators of intracellular therapeutic targets: Application to proliferating cell nuclear antigen (PCNA)
S Lim, R Khoo, KM Peh, J Teo, SC Chang, S Ng, GL Beilhartz, RA Melnyk, ...
bioRxiv, 728071, 2019
12019
C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms
CJ Brown, SG Dastidar, ST Quah, A Lim, B Chia, CS Verma
PLoS One 6 (8), e24122, 2011
282011
Conformational ordering of intrinsically disordered peptides for targeting translation initiation
CJ Brown, CS Verma, DP Lane, D Lama
Biochimica et Biophysica Acta (BBA)-General Subjects 1865 (1), 129775, 2021
22021
Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides
TJ Desai, B Habulihaz, JR Cannon, A Chandramohan, HYK Kaan, ...
Pharmaceutical research 38 (4), 735-736, 2021
2021
CRYSTAL STRUCTURE OF CAP-FREE HUMAN eIF4E
CJ BROWN
WO Patent 2,010,138,084, 2010
2010
Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site
CJ Brown, CS Verma, MD Walkinshaw, DP Lane
Cell Cycle 9 (19), 4031-4031, 2010
12010
Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site
CJ Brown, CS Verma, MD Walkinshaw, DP Lane
Cell Cycle 8 (12), 1905-1911, 2009
412009
Crystallographic and mass spectrometric characterisation of eIF4E with N 7-alkylated cap derivatives
CJ Brown, I McNae, PM Fischer, MD Walkinshaw
Journal of molecular biology 372 (1), 7-15, 2007
872007
De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits
S Ng, YC Juang, A Chandramohan, HYK Kaan, A Sadruddin, TY Yuen, ...
ACS Medicinal Chemistry Letters 11 (10), 1993-2001, 2020
272020
Design of a novel MDM2 binding peptide based on the p53 family
A Madhumalar, LH Jun, CJ Brown, DP Lane, CS Verma
Cell Cycle 8 (17), 2828-2836, 2009
342009
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