A comparative oncology drug discovery pipeline to identify and validate new treatments for osteosarcoma JA Somarelli, G Rupprecht, E Altunel, EM Flamant, S Rao, D Sivaraj, ... Cancers 12 (11), 3335, 2020 | 14 | 2020 |
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen J Moffat, DA Grueneberg, X Yang, SY Kim, AM Kloepfer, G Hinkle, ... Cell 124 (6), 1283-1298, 2006 | 2032 | 2006 |
A novel integrative genomic approach identifies CDK8 as a colon cancer oncogene R Firestein, A Bass, SY Kim, I Dunn, S Silver, I Guney, E Freed, ... Cancer Research 68 (9_Supplement), LB-282-LB-282, 2008 | | 2008 |
A novel, high-throughput approach to discovering drug-resistance genes identifies CRAF, CrkL, and TPL2/COT as drivers of resistance to BRAFV600E inhibition CM Johannessen, L Wardwell, SY Kim, J Boehm, S Thomas, LA Johnson, ... Cancer Research 70 (8_Supplement), 5769-5769, 2010 | | 2010 |
A precision medicine drug discovery pipeline to identify dual CDK2/9 inhibition as a novel treatment for colorectal cancer. R Salman Roghani, A Sanjari moghaddam, G Rupprecht, E Altunel, ... Journal of Clinical Oncology 38 (15_suppl), e16056-e16056, 2020 | 1 | 2020 |
A precision medicine strategy to identify the FGFR pathway as a novel target in colorectal cancer liver metastasis. E Altunel, J Somarelli, SY Kim, W Glover, G Rupprecht, SD Hsu Journal of Clinical Oncology 36 (4_suppl), 660-660, 2018 | | 2018 |
A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer KE Ware, BC Thomas, PD Olawuni, MU Sheth, N Hawkey, M Yeshwanth, ... Frontiers in Molecular Biosciences 10, 1104505, 2023 | 4 | 2023 |
A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor T Abaffy, JR Bain, MJ Muehlbauer, I Spasojevic, S Lodha, E Bruguera, ... Frontiers in Oncology 8, 162, 2018 | 42 | 2018 |
Abstract P5-08-01: Systematic interrogation of resistance to HER2-directed therapy identifies a survival pathway activated by PRKACA and PIM1 SE Moody, AC Schinzel, S Singh, F Izzo, MR Strickland, LY Luo, ... Cancer Research 73 (24_Supplement), P5-08-01-P5-08-01, 2013 | | 2013 |
Abstract# 3822: PDK1-SGK3 signaling in the absence of AKT activation in PIK3CA-mutant cancers K Vasudevan, D Barbie, M Davies, R Rabinovsky, B Hennessy, H Tseng, ... Cancer Research 69 (9_Supplement), 3822-3822, 2009 | 2 | 2009 |
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate MM Keenan, B Liu, X Tang, J Wu, D Cyr, RD Stevens, O Ilkayeva, ... PLoS genetics 11 (10), e1005599, 2015 | 40 | 2015 |
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer KM Vasudevan, DA Barbie, MA Davies, R Rabinovsky, CJ McNear, ... Cancer cell 16 (1), 21-32, 2009 | 620 | 2009 |
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase T Nobukuni, M Joaquin, M Roccio, SG Dann, SY Kim, P Gulati, MP Byfield, ... Proceedings of the National Academy of Sciences 102 (40), 14238-14243, 2005 | 952 | 2005 |
Amplification and overexpresssion of IKBKE activates NF-kB pathway in breast cancers. L Mulvey, J Boehm, I Dunn, SY Kim, J Yao, W Hahn, K Polyak Cancer Research 67 (9_Supplement), 5261-5261, 2007 | | 2007 |
An integrative systems biology and experimental approach identifies convergence of epithelial plasticity, metabolism, and autophagy to promote chemoresistance S Xu, KE Ware, Y Ding, SY Kim, MU Sheth, S Rao, W Chan, AJ Armstrong, ... Journal of Clinical Medicine 8 (2), 205, 2019 | 18 | 2019 |
bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens J Lin, J Gresham, T Wang, SY Kim, J Alvarez, JS Damrauer, S Floyd, ... Bioinformatics 34 (20), 3581-3583, 2018 | 5 | 2018 |
Cancer genomics: integrating form and function SY Kim, WC Hahn Carcinogenesis 28 (7), 1387-1392, 2007 | 33 | 2007 |
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity R Firestein, AJ Bass, SY Kim, IF Dunn, SJ Silver, I Guney, E Freed, ... Nature 455 (7212), 547-551, 2008 | 804 | 2008 |
CK1ε is required for breast cancers dependent on β-catenin activity SY Kim, IF Dunn, R Firestein, P Gupta, L Wardwell, K Repich, AC Schinzel, ... PloS one 5 (2), e8979, 2010 | 100 | 2010 |
Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae DE Anderson, K Pfeffermann, SY Kim, B Sawatsky, J Pearson, M Kovtun, ... MBio 10 (3), 10.1128/mbio. 00826-19, 2019 | 24 | 2019 |