168 CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN SMOKERS ARE DYSFUNCTIONAL DUE TO INCREASED DNA DAMAGE AND SENESCENCE KE Paschalaki, RD Starke, Y Hu, N Mercado, A Margariti, VG Gorgoulis, ... Heart 99 (suppl 2), A97, 2013 | | 2013 |
59 Endothelial colony forming cells (ECFC) are senescent and dysfunctional in COPD due to reduced sirtuin-1 levels K Paschalaki, RD Starke, N Mercado, DO Haskard, PJ Barnes, AM Randi Heart 97 (20), e7-e7, 2011 | 6 | 2011 |
A CARD10-dependent tonic signalosome activates MALT1 paracaspase and regulates IL-17/TNF-α-driven keratinocyte inflammation L Israël, M Bardet, A Huppertz, N Mercado, S Ginster, A Unterreiner, ... The Journal of investigative dermatology 138 (9), 2075-2079, 2018 | 22 | 2018 |
A novel target of formoterol, a dual-specificity phosphatase DUSP4 on regulation of corticosteroid budesonide sensitivity Y Kobayashi, N Mercado, A Miller-Larsson, P Barnes, K Ito European Respiratory Journal 38 (Suppl 55), 2011 | | 2011 |
A role of mTOR in cigarette smoke-induced corticosteroid insensitivity A Mitani, N Mercado, PJ Barnes, K Ito European Respiratory Journal 40 (Suppl 56), 2012 | 1 | 2012 |
Accelerated ageing of the lung in COPD: new concepts N Mercado, K Ito, PJ Barnes Thorax 70 (5), 482-489, 2015 | 422 | 2015 |
Activated protein phosphatase PP2A by formoterol enhances nuclear translocation of glucocorticoid receptor induced by budesonide Y Kobayashi, N Mercado, A Miller-Larsson, P Barnes, K Ito European Respiratory Journal 38 (Suppl 55), 2011 | | 2011 |
Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers N Mercado, Y Kizawa, K Ueda, Y Xiong, G Kimura, A Moses, JM Curtis, ... PLoS One 9 (2), e88168, 2014 | 39 | 2014 |
AMPK signalling regulates Nrf2 localization and activity via sirtuins in a monocytic cell line LN Naveira, N Mercado, K Ito European Respiratory Journal 38 (Suppl 55), 2011 | 7 | 2011 |
An Activator Of AMP Activated Kinase (AMPK) Restores Nrf2 Protein Levels Decreased By Chronic Cigarette Smoke Exposure N Mercado, A Turner, L Nunez Naveira, K Ito, PJ Barnes A30. PULMONARY VICES: CIGARETTE SMOKE, ALCOHOL AND OXIDATIVE STRESS …, 2012 | 1 | 2012 |
Anti‐Ageing Strategy of the Lung for Chronic Inflammatory Respiratory Disease–Targeting Protein Deacetylases K Ito, N Mercado Molecular and Cellular Therapeutics, 125-139, 2012 | | 2012 |
Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease N Mercado, T Colley, JR Baker, C Vuppussetty, Y Kono, C Clarke, ... FASEB bioAdvances 1 (11), 688, 2019 | 15 | 2019 |
Blood outgrowth endothelial cells are senescent and dysfunctional in COPD due to increased DNA damage; implications for endothelial dysfunction K Paschalaki, R Starke, N Mercado, V Gorgoulis, AM Randi, PJ Barnes European Respiratory Journal 40 (Suppl 56), 2012 | | 2012 |
Bromodomain and extra-terminal (BET) proteins regulate antioxidant gene expression C Michaeloudes, N Mercado, PJ Barnes, IM Adcock, KF Chung European Respiratory Journal 42 (Suppl 57), 2013 | | 2013 |
Bromodomain and extraterminal proteins suppress NF-E2–related factor 2–mediated antioxidant gene expression C Michaeloudes, N Mercado, C Clarke, PK Bhavsar, IM Adcock, ... The Journal of Immunology 192 (10), 4913-4920, 2014 | 72 | 2014 |
Cigarette smoke impairs autophagic flux in bronchial epithelial cells N Mercado, T Colley, K Ito, P Barnes European Respiratory Journal 42 (Suppl 57), 2013 | 3 | 2013 |
Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation Y Kono, T Colley, M To, AI Papaioannou, N Mercado, JR Baker, Y To, ... Scientific reports 11 (1), 335, 2021 | 28 | 2021 |
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress N Mercado, R Thimmulappa, CMR Thomas, PS Fenwick, KK Chana, ... Biochemical and biophysical research communications 406 (2), 292-298, 2011 | 236 | 2011 |
Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma T Colley, N Mercado, Y Kunori, C Brightling, PK Bhavsar, PJ Barnes, K Ito Journal of Allergy and Clinical Immunology 137 (5), 1595-1597. e7, 2016 | 42 | 2016 |
Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma Y Kobayashi, N Mercado, PJ Barnes, K Ito PloS one 6 (12), e27627, 2011 | 114 | 2011 |