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Sibylle Neuhoff
Sibylle Neuhoff
Sr. Principal Scientist & Deputy Trans. Sci., Certara UK (Simcyp Division), Sheffield
在 certara.com 的电子邮件经过验证
标题
引用次数
年份
A Cross-Laboratory Comparison of Caco-2 and Human Intestinal Drug Transporter Protein Abundances
MD Harwood, B Achour, Y Courbebaisse, MR Russell, S Neuhoff, ...
DMDG and GMP Joint Meeting, 2014
2014
A Dynamic Physiologically-Based Pharmacokinetic (PBPK) Model to Predict the Disposition of Rosuvastatin in Human and the Extent of Drug-Drug Interactions
A Rostami-Hochaghan, F Bajot, S Neuhoff, Z Barter, K Rowland-Yeo, ...
AAPS Annual Meeting and Exposition, Chicago, IL, USA, 2012
2012
A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator
L Curry, S Alrubia, FY Bois, R Clayton, E El‐Khateeb, TN Johnson, ...
CPT: Pharmacometrics & Systems Pharmacology, 2024
2024
A laboratory-specific scaling factor to predict the in vivo human clearance of aldehyde oxidase substrates
MDS Mendes, AL Orton, HE Humphries, B Jones, I Gardner, S Neuhoff, ...
Drug Metabolism and Disposition 48 (11), 1231-1238, 2020
122020
A mechanistic framework for in vitro–in vivo extrapolation of liver membrane transporters: prediction of drug–drug interaction between rosuvastatin and cyclosporine
M Jamei, F Bajot, S Neuhoff, Z Barter, J Yang, A Rostami-Hodjegan, ...
Clinical pharmacokinetics 53, 73-87, 2014
1822014
A MECHANISTIC PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL TO PREDICT THE PHARMACOKINETICS OF R/S-OXAZEPAM AFTER ORAL DOSING
DB Turner, D Pade, M Jamei, S Neuhoff
Drug Metabolism Reviews 47, 221-222, 2015
2015
A physiologically based pharmacokinetic modeling approach for predicting the exposure of irinotecan and its active metabolite (SN-38) in cancer patients
KZ Denic, S Neuhoff, J Reid, R Kudget
MOLECULAR CANCER THERAPEUTICS 22 (12), 2023
2023
A Physiologically-Based Pharmacokinetic Model to Predict the Disposition of Topotecan in Transporter Wild Type and Knock-Out Mice
DS Pade, S Neuhoff, DB Turner, M Jamei, A Rostami-Hodjegan
A user-friendly physiologically-based pharmacokinetic (PBPK) brain model and its application in simulating drug disposition in brain
A Rostami-Hochaghan, G Lu, S Neuhoff, M Jamei, A Rostami-Hodjegan
26th JSSX Annual Meeting, Hiroshima, Japan, 2011
2011
Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro–in vivo extrapolation of oral drug absorption
MD Harwood, S Neuhoff, GL Carlson, G Warhurst, A Rostami‐Hodjegan
Biopharmaceutics & drug disposition 34 (1), 2-28, 2013
1242013
Abstract A140: A physiologically based pharmacokinetic modeling approach for predicting the exposure of irinotecan and its active metabolite (SN-38) in cancer patients
KZ Denic, S Neuhoff, J Reid, R Kudget
Molecular Cancer Therapeutics 22 (12_Supplement), A140-A140, 2023
2023
Abundance & relative segmental expression of intestinal transporters in caucasians: A meta-analysis
MD Harwood, M Zhang, S Pathak, I Gardner, S Neuhoff
Drug Metabolism and Pharmacokinetics 33 (1), S88-S89, 2018
2018
Abundance of hepatic transporters in caucasians: a meta-analysis
AE Riedmaier, H Burt, K Gill, M Harwood, S Neuhoff
DRUG METABOLISM REVIEWS 48, 140-140, 2016
2016
Abundance of hepatic transporters in Caucasians: a meta-analysis
HJ Burt, AE Riedmaier, MD Harwood, HK Crewe, KL Gill, S Neuhoff
Drug metabolism and disposition 44 (10), 1550-1561, 2016
842016
Acamprosate has no impact on the permeability of paracellular markers across Caco-2 cells
I Antonescu, B Steffansen, S Neuhoff
6th FIP Pharmaceutical Sciences World Congress 2017: Future Medicines For …, 2017
2017
Acamprosate is a substrate of the human organic anion transporter (OAT) 1 without OAT3 inhibitory properties: implications for renal acamprosate secretion and drug–drug …
IE Antonescu, M Karlgren, ML Pedersen, I Simoff, CAS Bergström, ...
Pharmaceutics 12 (4), 390, 2020
82020
Acamprosate is an inhibitor of the renal organic anion transporter (OAT) 1
IE Antonescu, M Karlgren, M Pedersen, I Simoff, C Bergström, S Neuhoff, ...
2019
Acamprosate permeability across Caco-2 cell monolayer is predominantly paracellular
IE Antonescu, S Neuhoff, X Fretté, CU Nielsen, B Steffansen
Northern Pharma Network Meeting & POP Kick off-Meeting Conference 2018, Odense, 2018
2018
Accounting for transporters in renal clearance: towards a mechanistic kidney model (Mech KiM)
S Neuhoff, L Gaohua, H Burt, M Jamei, L Li, GT Tucker, ...
Transporters in drug development: discovery, optimization, clinical study …, 2013
782013
Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers
S Neuhoff, P Artursson, AL Ungell
Journal of drug delivery science and technology 17 (4), 259-266, 2007
62007
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