The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability S Mirali, A Botham, V Voisin, C Xu, J St-Germain, D Sharon, FW Hoff, ... Science Translational Medicine 12 (538), eaaz8264, 2020 | 42 | 2020 |
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness GE Thomas, G Egan, L García-Prat, A Botham, V Voisin, PS Patel, ... Nature cell biology 24 (6), 872-884, 2022 | 38 | 2022 |
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia N Baran, A Lodi, Y Dhungana, S Herbrich, M Collins, S Sweeney, ... Nature communications 13 (1), 2801, 2022 | 30 | 2022 |
Recognition of recurrent protein expression patterns in pediatric acute myeloid leukemia identified new therapeutic targets FW Hoff, CW Hu, Y Qiu, A Ligeralde, SY Yoo, H Mahmud, ESJM De Bont, ... Molecular Cancer Research 16 (8), 1275-1286, 2018 | 21 | 2018 |
Histone modification patterns using RPPA‐based profiling predict outcome in acute myeloid leukemia patients AD van Dijk, CW Hu, ESJM de Bont, YH Qiu, FW Hoff, SY Yoo, ... Proteomics 18 (8), 1700379, 2018 | 19 | 2018 |
RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit HD Chae, R Dutta, B Tiu, FW Hoff, B Accordi, V Serafin, M Youn, M Huang, ... Oncotarget 11 (25), 2387, 2020 | 17 | 2020 |
Recurrent patterns of protein expression signatures in pediatric acute lymphoblastic leukemia: recognition and therapeutic guidance FW Hoff, CW Hu, Y Qiu, A Ligeralde, SY Yoo, ME Scheurer, ... Molecular Cancer Research 16 (8), 1263-1274, 2018 | 17 | 2018 |
Heat shock factor 1 (HSF1-pSer326) predicts response to bortezomib-containing chemotherapy in pediatric AML: a COG report FW Hoff, AD van Dijk, Y Qiu, PP Ruvolo, RB Gerbing, AR Leonti, ... Blood, The Journal of the American Society of Hematology 137 (8), 1050-1060, 2021 | 16 | 2021 |
BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway M Butler, DS van Ingen Schenau, J Yu, S Jenni, MP Dobay, R Hagelaar, ... Blood, The Journal of the American Society of Hematology 138 (23), 2383-2395, 2021 | 15 | 2021 |
Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia AD van Dijk, FW Hoff, YH Qiu, J Chandra, E Jabbour, E de Bont, ... Clinical epigenetics 13, 1-16, 2021 | 15 | 2021 |
Clinical relevance of proteomic profiling in de novo pediatric acute myeloid leukemia: a Children’s Oncology Group study FW Hoff, AD Van Dijk, Y Qiu, CW Hu, RE Ries, A Ligeralde, GN Jenkins, ... Haematologica 107 (10), 2329, 2022 | 11 | 2022 |
The effects of sample handling on proteomics assessed by reverse phase protein arrays (RPPA): functional proteomic profiling in leukemia TM Horton, FW Hoff, A van Dijk, GN Jenkins, D Morrison, T Bhatla, ... Journal of proteomics 233, 104046, 2021 | 11 | 2021 |
Proteomic profiling based classification of CLL provides prognostication for modern therapy and identifies novel therapeutic targets TL Griffen, FW Hoff, Y Qiu, JW Lillard Jr, A Ferrajoli, P Thompson, E Toro, ... Blood cancer journal 12 (3), 43, 2022 | 9 | 2022 |
Proteomic profiling of acute promyelocytic leukemia identifies two protein signatures associated with relapse FW Hoff, CW Hu, AA Qutub, Y Qiu, MJ Hornbaker, C Bueso‐Ramos, ... PROTEOMICS–Clinical Applications 13 (4), 1800133, 2019 | 8 | 2019 |
Mycoplasma contamination of leukemic cell lines alters protein expression determined by reverse phase protein arrays FW Hoff, CW Hu, AA Qutub, Y Qiu, E Graver, G Hoang, M Chauhan, ... Cytotechnology 70, 1529-1535, 2018 | 8 | 2018 |
Identifying cancer specific metabolic signatures using constraint-based models A Schultz, S Mehta, CW Hu, FW Hoff, TM Horton, SM Kornblau, AA Qutub PACIFIC SYMPOSIUM ON BIOCOMPUTING 2017, 485-496, 2017 | 8 | 2017 |
Molecular Drivers of Myelodysplastic Neoplasms (MDS)—Classification and Prognostic Relevance FW Hoff, YF Madanat Cells 12 (4), 627, 2023 | 7 | 2023 |
Bortezomib is significantly beneficial for de novo pediatric AML patients with low phosphorylation of the NF‐κB subunit RelA AD van Dijk, FW Hoff, Y Qiu, RB Gerbing, AS Gamis, R Aplenc, EA Kolb, ... PROTEOMICS–Clinical Applications 16 (2), 2100072, 2022 | 6 | 2022 |
RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences AD van Dijk, TL Griffen, YH Qiu, FW Hoff, E Toro, K Ruiz, PP Ruvolo, ... Leukemia 36 (3), 712-722, 2022 | 6 | 2022 |
Real-world outcomes of frontline venetoclax-based therapy in older adults with acute myeloid leukemia: an analysis utilizing EHR data FW Hoff, PA Patel, AJ Belli, E Hansen, H Foss, M Schulte, CK Wang, ... Leukemia & Lymphoma 64 (6), 1123-1128, 2023 | 5 | 2023 |