Coronaviruses: an overview of their replication and pathogenesis AR Fehr, S Perlman Coronaviruses: methods and protocols, 1-23, 2015 | 5016 | 2015 |
Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice R Channappanavar, AR Fehr, R Vijay, M Mack, J Zhao, DK Meyerholz, ... Cell host & microbe 19 (2), 181-193, 2016 | 1620 | 2016 |
IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes R Channappanavar, AR Fehr, J Zheng, C Wohlford-Lenane, ... The Journal of clinical investigation 129 (9), 3625-3639, 2019 | 625 | 2019 |
β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway S Ghosh, TA Dellibovi-Ragheb, A Kerviel, E Pak, Q Qiu, M Fisher, ... Cell 183 (6), 1520-1535. e14, 2020 | 529 | 2020 |
Middle East respiratory syndrome: emergence of a pathogenic human coronavirus AR Fehr, R Channappanavar, S Perlman Annual review of medicine 68, 387-399, 2017 | 366 | 2017 |
Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism JE Park, K Li, A Barlan, AR Fehr, S Perlman, PB McCray Jr, T Gallagher Proceedings of the National Academy of Sciences 113 (43), 12262-12267, 2016 | 329 | 2016 |
The conserved coronavirus macrodomain promotes virulence and suppresses the innate immune response during severe acute respiratory syndrome coronavirus infection AR Fehr, R Channappanavar, G Jankevicius, C Fett, J Zhao, J Athmer, ... MBio 7 (6), 10.1128/mbio. 01721-16, 2016 | 197 | 2016 |
ADP‐ribosyltransferases, an update on function and nomenclature B Lüscher, I Ahel, M Altmeyer, A Ashworth, P Bai, P Chang, M Cohen, ... The FEBS journal 289 (23), 7399-7410, 2022 | 193 | 2022 |
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity CD Heer, DJ Sanderson, LS Voth, YMO Alhammad, MS Schmidt, ... Journal of Biological Chemistry 295 (52), 17986-17996, 2020 | 193 | 2020 |
The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions AR Fehr, SA Singh, CM Kerr, S Mukai, H Higashi, M Aikawa Genes & development 34 (5-6), 341-359, 2020 | 184 | 2020 |
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression ME Grunewald, Y Chen, C Kuny, T Maejima, R Lease, D Ferraris, ... PLoS pathogens 15 (5), e1007756, 2019 | 176 | 2019 |
The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis AR Fehr, J Athmer, R Channappanavar, JM Phillips, DK Meyerholz, ... Journal of virology 89 (3), 1523-1536, 2015 | 164 | 2015 |
Coronaviruses: methods and protocols AR Fehr, S Perlman, HJ Maier, E Bickerton Methods Mol Biol. Springer Science, 1-282, 2015 | 151 | 2015 |
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection J Canton, AR Fehr, R Fernandez-Delgado, FJ Gutierrez-Alvarez, ... PLoS pathogens 14 (1), e1006838, 2018 | 135 | 2018 |
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element ACG Kankanamalage, Y Kim, VC Damalanka, AD Rathnayake, AR Fehr, ... European journal of medicinal chemistry 150, 334-346, 2018 | 114 | 2018 |
Viral macrodomains: unique mediators of viral replication and pathogenesis AR Fehr, G Jankevicius, I Ahel, S Perlman Trends in microbiology 26 (7), 598-610, 2018 | 109 | 2018 |
In Vitro and In Vivo Characterization of the Pseudomonas aeruginosa Cyclic AMP (cAMP) Phosphodiesterase CpdA, Required for cAMP Homeostasis and … EL Fuchs, ED Brutinel, ER Klem, AR Fehr, TL Yahr, MC Wolfgang Journal of bacteriology 192 (11), 2779-2790, 2010 | 106 | 2010 |
The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase YMO Alhammad, MM Kashipathy, A Roy, JP Gagné, P McDonald, P Gao, ... Journal of virology 95 (3), 10.1128/jvi. 01969-20, 2021 | 99 | 2021 |
The viral macrodomain counters host antiviral ADP-ribosylation YMO Alhammad, AR Fehr Viruses 12 (4), 384, 2020 | 95 | 2020 |
The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts YC Perng, Z Qian, AR Fehr, B Xuan, D Yu Journal of virology 85 (10), 4841-4852, 2011 | 79 | 2011 |