Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets RD Michalek, VA Gerriets, SR Jacobs, AN Macintyre, NJ MacIver, ... The Journal of immunology 186 (6), 3299-3303, 2011 | 2153 | 2011 |
Metabolic regulation of T lymphocytes NJ MacIver, RD Michalek, JC Rathmell Annual review of immunology 31 (1), 259-283, 2013 | 1328 | 2013 |
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways SR Jacobs, CE Herman, NJ MacIver, JA Wofford, HL Wieman, ... The Journal of Immunology 180 (7), 4476-4486, 2008 | 923 | 2008 |
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation VA Gerriets, RJ Kishton, AG Nichols, AN Macintyre, M Inoue, O Ilkayeva, ... The Journal of clinical investigation 125 (1), 194-207, 2015 | 693 | 2015 |
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival NJ MacIver, SR Jacobs, HL Wieman, JA Wofford, JL Coloff, JC Rathmell Journal of Leucocyte Biology 84 (4), 949-957, 2008 | 594 | 2008 |
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression VA Gerriets, RJ Kishton, MO Johnson, S Cohen, PJ Siska, AG Nichols, ... Nature immunology 17 (12), 1459-1466, 2016 | 497 | 2016 |
Changes in nutritional status impact immune cell metabolism and function Y Alwarawrah, K Kiernan, NJ MacIver Frontiers in immunology 9, 1055, 2018 | 493 | 2018 |
RelB cellular regulation and transcriptional activity are regulated by p100 NJ Solan, H Miyoshi, EM Carmona, GD Bren, CV Paya Journal of Biological Chemistry 277 (2), 1405-1418, 2002 | 334 | 2002 |
Transcription of the RelB gene is regulated by NF-κB GD Bren, NJ Solan, H Miyoshi, KN Pennington, LJ Pobst, CV Paya Oncogene 20 (53), 7722-7733, 2001 | 279 | 2001 |
Leptin metabolically licenses T cells for activation to link nutrition and immunity DC Saucillo, VA Gerriets, J Sheng, JC Rathmell, NJ MacIver The Journal of Immunology 192 (1), 136-144, 2014 | 278 | 2014 |
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism NJ MacIver, J Blagih, DC Saucillo, L Tonelli, T Griss, JC Rathmell, ... The Journal of Immunology 187 (8), 4187-4198, 2011 | 266 | 2011 |
Nutritional effects on T‐cell immunometabolism S Cohen, K Danzaki, NJ MacIver European journal of immunology 47 (2), 225-235, 2017 | 189 | 2017 |
Role of T cells in malnutrition and obesity VA Gerriets, NJ MacIver Frontiers in Immunology 5, 379, 2014 | 160 | 2014 |
Suppression of Glut1 and glucose metabolism by decreased Akt/mTORC1 signaling drives T cell impairment in B cell leukemia PJ Siska, GJW van der Windt, RJ Kishton, S Cohen, W Eisner, NJ MacIver, ... The Journal of Immunology 197 (6), 2532-2540, 2016 | 151 | 2016 |
Leptin directly promotes T‐cell glycolytic metabolism to drive effector T‐cell differentiation in a mouse model of autoimmunity VA Gerriets, K Danzaki, RJ Kishton, W Eisner, AG Nichols, DC Saucillo, ... European journal of immunology 46 (8), 1970-1983, 2016 | 118 | 2016 |
The role of the adipokine leptin in immune cell function in health and disease K Kiernan, NJ MacIver Frontiers in immunology 11, 622468, 2021 | 113 | 2021 |
Systematic dissection of the metabolic-apoptotic interface in AML reveals heme biosynthesis to be a regulator of drug sensitivity KH Lin, A Xie, JC Rutter, Y Ahn, JM Lloyd-Cowden, AG Nichols, ... Cell metabolism 29 (5), 1217-1231. e7, 2019 | 93 | 2019 |
Obesity-induced changes in T-cell metabolism are associated with impaired memory T-cell response to influenza and are not reversed with weight loss J Rebeles, WD Green, Y Alwarawrah, AG Nichols, W Eisner, K Danzaki, ... The Journal of Infectious Diseases 219 (10), 1652-1661, 2019 | 82 | 2019 |
Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature S Petrovski, RE Parrott, JL Roberts, H Huang, J Yang, B Gorentla, ... Journal of clinical immunology 36, 462-471, 2016 | 58 | 2016 |
Functional heterogeneity of alveolar macrophage population based on expression of CXCL2 S Xu-Vanpala, ME Deerhake, JD Wheaton, ME Parker, PR Juvvadi, ... Science immunology 5 (50), eaba7350, 2020 | 52 | 2020 |