| The leucine-rich repeat structure J Bella, KL Hindle, PA McEwan, SC Lovell Cellular and Molecular Life Sciences 65, 2307-2333, 2008 | 577 | 2008 |
| Structure and function of factor XI J Emsley, PA McEwan, D Gailani Blood, The Journal of the American Society of Hematology 115 (13), 2569-2577, 2010 | 268 | 2010 |
| Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan PG Scott, PA McEwan, CM Dodd, EM Bergmann, PN Bishop, J Bella Proceedings of the National Academy of Sciences 101 (44), 15633-15638, 2004 | 260 | 2004 |
| Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans PA McEwan, PG Scott, PN Bishop, J Bella Journal of structural biology 155 (2), 294-305, 2006 | 249 | 2006 |
| Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble MJ Humphries, PA McEwan, SJ Barton, PA Buckley, J Bella, AP Mould Trends in biochemical sciences 28 (6), 313-320, 2003 | 220 | 2003 |
| Conformational Changes in the Integrin औA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement AP Mould, SJ Barton, JA Askari, PA McEwan, PA Buckley, SE Craig, ... Journal of Biological Chemistry 278 (19), 17028-17035, 2003 | 162 | 2003 |
| Integrin activation involves a conformational change in the α1 helix of the β subunit A-domain AP Mould, JA Askari, S Barton, AD Kline, PA McEwan, SE Craig, ... Journal of Biological Chemistry 277 (22), 19800-19805, 2002 | 160 | 2002 |
| Crystal structure of the factor XI zymogen reveals a pathway for transactivation E Papagrigoriou, PA McEwan, PN Walsh, J Emsley Nature structural & molecular biology 13 (6), 557-558, 2006 | 147 | 2006 |
| Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis AP Mould, EJH Symonds, PA Buckley, JG Grossmann, PA McEwan, ... Journal of Biological Chemistry 278 (41), 39993-39999, 2003 | 119 | 2003 |
| Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia F Wadelin, J Fulton, PA McEwan, KA Spriggs, J Emsley, DM Heery Molecular cancer 9, 1-10, 2010 | 108 | 2010 |
| Fragment molecular orbital method applied to lead optimization of novel interleukin-2 inducible T-cell kinase (ITK) inhibitors A Heifetz, G Trani, M Aldeghi, CH MacKinnon, PA McEwan, FA Brookfield, ... Journal of medicinal chemistry 59 (9), 4352-4363, 2016 | 83 | 2016 |
| Development of a selective inhibitor of protein arginine deiminase 2 A Muth, V Subramanian, E Beaumont, M Nagar, P Kerry, P McEwan, ... Journal of medicinal chemistry 60 (7), 3198-3211, 2017 | 79 | 2017 |
| Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera PA McEwan, W Yang, KH Carr, X Mo, X Zheng, R Li, J Emsley Blood, The Journal of the American Society of Hematology 118 (19), 5292-5301, 2011 | 67 | 2011 |
| Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K) GM Castanedo, N Blaquiere, M Beresini, B Bravo, H Brightbill, J Chen, ... Journal of medicinal chemistry 60 (2), 627-640, 2017 | 62 | 2017 |
| End-stapled homo and hetero collagen triple helices: a click chemistry approach C Byrne, PA McEwan, J Emsley, PM Fischer, WC Chan Chemical communications 47 (9), 2589-2591, 2011 | 49 | 2011 |
| Glycoprotein Ibα inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism PA McEwan, RK Andrews, J Emsley Blood, The Journal of the American Society of Hematology 114 (23), 4883-4885, 2009 | 45 | 2009 |
| Scaffold-hopping approach to discover potent, selective, and efficacious inhibitors of NF-κB inducing kinase N Blaquiere, GM Castanedo, JD Burch, LM Berezhkovskiy, H Brightbill, ... Journal of Medicinal Chemistry 61 (15), 6801-6813, 2018 | 43 | 2018 |
| Molecular modeling of the prekallikrein structure provides insights into high‐molecular‐weight kininogen binding and zymogen activation E Hooley, PA McEwan, J Emsley Journal of Thrombosis and Haemostasis 5 (12), 2461-2466, 2007 | 42 | 2007 |
| Tetrahydroindazoles as interleukin-2 inducible T-cell kinase inhibitors. Part II. Second-generation analogues with enhanced potency, selectivity, and pharmacodynamic modulation … JD Burch, K Barrett, Y Chen, J DeVoss, C Eigenbrot, R Goldsmith, ... Journal of Medicinal Chemistry 58 (9), 3806-3816, 2015 | 41 | 2015 |
| Property-and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors JD Burch, K Lau, JJ Barker, F Brookfield, Y Chen, Y Chen, C Eigenbrot, ... Journal of Medicinal Chemistry 57 (13), 5714-5727, 2014 | 32 | 2014 |
