| The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors M Hedvat, D Huszar, A Herrmann, JM Gozgit, A Schroeder, A Sheehy, ... Cancer cell 16 (6), 487-497, 2009 | 603 | 2009 |
| Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines CT Walsh, H Chen, TA Keating, BK Hubbard, HC Losey, L Luo, ... Current opinion in chemical biology 5 (5), 525-534, 2001 | 435 | 2001 |
| AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia EK Keeton, K McEachern, KS Dillman, S Palakurthi, Y Cao, MR Grondine, ... Blood, The Journal of the American Society of Hematology 123 (6), 905-913, 2014 | 265 | 2014 |
| BRD4 inhibition is synthetic lethal with PARP inhibitors through the induction of homologous recombination deficiency C Sun, J Yin, Y Fang, J Chen, KJ Jeong, X Chen, CP Vellano, Z Ju, ... Cancer cell 33 (3), 401-416. e8, 2018 | 258 | 2018 |
| Coumarin formation in novobiocin biosynthesis: β-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI H Chen, CT Walsh Chemistry & biology 8 (4), 301-312, 2001 | 238 | 2001 |
| Structural basis of substrate methylation and inhibition of SMYD2 AD Ferguson, NA Larsen, T Howard, H Pollard, I Green, C Grande, ... Structure 19 (9), 1262-1273, 2011 | 219 | 2011 |
| Formation of β-hydroxy histidine in the biosynthesis of nikkomycin antibiotics H Chen, BK Hubbard, SE O'Connor, CT Walsh Chemistry & biology 9 (1), 103-112, 2002 | 170 | 2002 |
| Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1 J Wu, K Mikule, W Wang, N Su, P Petteruti, F Gharahdaghi, E Code, X Zhu, ... ACS chemical biology 8 (10), 2201-2208, 2013 | 165 | 2013 |
| Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol J Wu, F Powell, NA Larsen, Z Lai, KF Byth, J Read, RF Gu, M Roth, ... ACS chemical biology 8 (3), 643-650, 2013 | 161 | 2013 |
| CloQ, a prenyltransferase involved in clorobiocin biosynthesis F Pojer, E Wemakor, B Kammerer, H Chen, CT Walsh, SM Li, L Heide Proceedings of the National Academy of Sciences 100 (5), 2316-2321, 2003 | 155 | 2003 |
| AZD5153: a novel bivalent BET bromodomain inhibitor highly active against hematologic malignancies GW Rhyasen, MM Hattersley, Y Yao, A Dulak, W Wang, P Petteruti, ... Molecular cancer therapeutics 15 (11), 2563-2574, 2016 | 144 | 2016 |
| Potent and selective bivalent inhibitors of BET bromodomains MJ Waring, H Chen, AA Rabow, G Walker, R Bobby, S Boiko, ... Nature chemical biology 12 (12), 1097-1104, 2016 | 140 | 2016 |
| Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6 W McCoull, T Cheung, E Anderson, P Barton, J Burgess, K Byth, Q Cao, ... ACS Chemical Biology 13 (11), 3131-3141, 2018 | 134 | 2018 |
| Deoxysugars in glycopeptide antibiotics: Enzymatic synthesis of TDP-l-epivancosamine in chloroeremomycin biosynthesis H Chen, MG Thomas, BK Hubbard, HC Losey, CT Walsh, MD Burkart Proceedings of the National Academy of Sciences 97 (22), 11942-11947, 2000 | 134 | 2000 |
| Glycopeptide antibiotic biosynthesis: Enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine H Chen, CC Tseng, BK Hubbard, CT Walsh Proceedings of the National Academy of Sciences 98 (26), 14901-14906, 2001 | 132 | 2001 |
| Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit H Chen, S O’Connor, DE Cane, CT Walsh Chemistry & biology 8 (9), 899-912, 2001 | 120 | 2001 |
| Discovery of novel benzylidene-1, 3-thiazolidine-2, 4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases LA Dakin, MH Block, H Chen, E Code, JE Dowling, X Feng, AD Ferguson, ... Bioorganic & medicinal chemistry letters 22 (14), 4599-4604, 2012 | 113 | 2012 |
| BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer DO Adeegbe, S Liu, MM Hattersley, M Bowden, CW Zhou, S Li, R Vlahos, ... Cancer immunology research 6 (10), 1234-1245, 2018 | 94 | 2018 |
| BRD4 facilitates replication stress-induced DNA damage response J Zhang, AM Dulak, MM Hattersley, BS Willis, J Nikkilä, A Wang, A Lau, ... Oncogene 37 (28), 3763-3777, 2018 | 86 | 2018 |
| Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3 R)-4-[2-[4-[1-(3-Methoxy-[1, 2, 4] triazolo [4, 3-b … RH Bradbury, R Callis, GR Carr, H Chen, E Clark, L Feron, S Glossop, ... Journal of medicinal chemistry 59 (17), 7801-7817, 2016 | 80 | 2016 |
