Structural biology and drug discovery for protein–protein interactions H Jubb, AP Higueruelo, A Winter, TL Blundell Trends in pharmacological sciences 33 (5), 241-248, 2012 | 205 | 2012 |
Biophysical and computational fragment-based approaches to targeting protein–protein interactions: applications in structure-guided drug discovery A Winter, AP Higueruelo, M Marsh, A Sigurdardottir, WR Pitt, TL Blundell Quarterly reviews of biophysics 45 (4), 383-426, 2012 | 131 | 2012 |
Molecular modeling of prohibitin domains A Winter, O Kämäräinen, A Hofmann Proteins: Structure, Function, and Bioinformatics 68 (1), 353-362, 2007 | 71 | 2007 |
Characterization of three druggable hot-spots in the Aurora-A/TPX2 interaction using biochemical, biophysical, and fragment-based approaches PJ McIntyre, PM Collins, L Vrzal, K Birchall, LH Arnold, C Mpamhanga, ... ACS chemical biology 12 (11), 2906-2914, 2017 | 48 | 2017 |
Structural determinants for plant annexin− membrane interactions N Dabitz, NJ Hu, AM Yusof, N Tranter, A Winter, M Daley, O Zschörnig, ... Biochemistry 44 (49), 16292-16300, 2005 | 44 | 2005 |
Hookworm SCP/TAPS protein structure—a key to understanding host–parasite interactions and developing new interventions A Osman, CK Wang, A Winter, A Loukas, L Tribolet, RB Gasser, ... Biotechnology advances 30 (3), 652-657, 2012 | 38 | 2012 |
Natural MHC class I polymorphism controls the pathway of peptide dissociation from HLA-B27 complexes K Winkler, A Winter, C Rueckert, B Uchanska-Ziegler, U Alexiev Biophysical journal 93 (8), 2743-2755, 2007 | 38 | 2007 |
The crystal structure of calcium-bound annexin Gh1 from Gossypium hirsutum and its implications for membrane binding mechanisms of plant annexins NJ Hu, AM Yusof, A Winter, A Osman, AK Reeve, A Hofmann Journal of Biological Chemistry 283 (26), 18314-18322, 2008 | 28 | 2008 |
Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of … AG Sigurdardottir, A Winter, A Sobkowicz, M Fragai, D Chirgadze, ... Chemical Science 6 (11), 6147-6157, 2015 | 25 | 2015 |
Structural insights into separase architecture and substrate recognition through computational modelling of caspase-like and death domains A Winter, R Schmid, R Bayliss PLoS Computational Biology 11 (10), e1004548, 2015 | 21 | 2015 |
Biochemical characterization of annexin B1 from Cysticercus cellulosae A Winter, AM Yusof, E Gao, HL Yan, A Hofmann The FEBS journal 273 (14), 3238-3247, 2006 | 19 | 2006 |
Developing antagonists for the Met-HGF/SF protein–protein interaction using a fragment-based approach A Winter, AG Sigurdardottir, D DiCara, G Valenti, TL Blundell, E Gherardi Molecular cancer therapeutics 15 (1), 3-14, 2016 | 12 | 2016 |
A closed conformation of the Caenorhabditis elegans separase–securin complex G Bachmann, MW Richards, A Winter, F Beuron, E Morris, R Bayliss Open Biology 6 (4), 160032, 2016 | 10 | 2016 |
Molecular changes in dengue envelope protein domain III upon interaction with glycosaminoglycans JG Hyatt, S Prévost, JM Devos, CJ Mycroft-West, MA Skidmore, A Winter Pathogens 9 (11), 935, 2020 | 8 | 2020 |
Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain DM DiCara, DY Chirgadze, AR Pope, A Karatt-Vellatt, A Winter, P Slavny, ... Scientific reports 7 (1), 9000, 2017 | 8 | 2017 |
The crystal structure of calcium-bound annexin Gh1 from Gossypium hirsutum indicates different mechanisms of membrane binding in plant and animal annexins N Hu, A Yusof, A Winter, A Osman, A Reeve, A Hofmann J. Biol. Chem 283, 18314-18322, 2008 | 5 | 2008 |
Towards understanding the roles of prohibitins, multi-functional regulator proteins A Hofmann, A Winter Current Chemical Biology 2 (1), 11-19, 2008 | 3 | 2008 |
Effect of cardiolipin on the lamellarity and elongation of liposomes hydrated in PBS A Piccinini, J Kohlbrecher, D Moussaoui, A Winter, S Prévost Journal of Colloid and Interface Science 669, 844-855, 2024 | | 2024 |
Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein H Baber, A Aghajani, BH Gallimore, C Bethel, JG Hyatt, EFB King, ... Biochimie 223, 31-40, 2024 | | 2024 |
Accessing active fragments for drug discovery utilising nitroreductase biocatalysis L Holder, E Yuce, G Oriomah, A Jenkins, J Reynisson, A Winter, ... | | 2024 |