| Protein knockdown using methyl bestatin− ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins Y Itoh, M Ishikawa, M Naito, Y Hashimoto Journal of the American Chemical Society 132 (16), 5820-5826, 2010 | 407 | 2010 |
| Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors S Hamada, T Suzuki, K Mino, K Koseki, F Oehme, I Flamme, H Ozasa, ... Journal of medicinal chemistry 53 (15), 5629-5638, 2010 | 189 | 2010 |
| Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries T Suzuki, Y Ota, M Ri, M Bando, A Gotoh, Y Itoh, H Tsumoto, PR Tatum, ... Journal of medicinal chemistry 55 (22), 9562-9575, 2012 | 187 | 2012 |
| Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate T Suzuki, A Kouketsu, Y Itoh, S Hisakawa, S Maeda, M Yoshida, ... Journal of medicinal chemistry 49 (16), 4809-4812, 2006 | 168 | 2006 |
| Hippocampal microRNA-124 enhances chronic stress resilience in mice F Higuchi, S Uchida, H Yamagata, N Abe-Higuchi, T Hobara, K Hara, ... Journal of Neuroscience 36 (27), 7253-7267, 2016 | 163 | 2016 |
| Design, synthesis, structure− selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors Y Itoh, T Suzuki, A Kouketsu, N Suzuki, S Maeda, M Yoshida, ... Journal of medicinal chemistry 50 (22), 5425-5438, 2007 | 159 | 2007 |
| Design, synthesis and biological evaluation of nuclear receptor-degradation inducers Y Itoh, R Kitaguchi, M Ishikawa, M Naito, Y Hashimoto Bioorganic & medicinal chemistry 19 (22), 6768-6778, 2011 | 156 | 2011 |
| Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors T Suzuki, MNA Khan, H Sawada, E Imai, Y Itoh, K Yamatsuta, N Tokuda, ... Journal of Medicinal Chemistry 55 (12), 5760-5773, 2012 | 140 | 2012 |
| Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors S Hamada, TD Kim, T Suzuki, Y Itoh, H Tsumoto, H Nakagawa, ... Bioorganic & medicinal chemistry letters 19 (10), 2852-2855, 2009 | 140 | 2009 |
| Isoform-selective histone deacetylase inhibitors T Suzuki, Y Itoh, N Miyata Current pharmaceutical design 14 (6), 529-544, 2008 | 138 | 2008 |
| Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein K Okuhira, N Ohoka, K Sai, T Nishimaki-Mogami, Y Itoh, M Ishikawa, ... FEBS letters 585 (8), 1147-1152, 2011 | 132 | 2011 |
| Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists T Suzuki, S Igari, A Hirasawa, M Hata, M Ishiguro, H Fujieda, Y Itoh, ... Journal of medicinal chemistry 51 (23), 7640-7644, 2008 | 129 | 2008 |
| N+-C-H···O Hydrogen bonds in protein-ligand complexes Y Itoh, Y Nakashima, S Tsukamoto, T Kurohara, M Suzuki, Y Sakae, ... Scientific reports 9 (1), 767, 2019 | 120 | 2019 |
| Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly T Suzuki, Y Kasuya, Y Itoh, Y Ota, P Zhan, K Asamitsu, H Nakagawa, ... PLoS One 8 (7), e68669, 2013 | 108 | 2013 |
| Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism. D Ogasawara, Y Itoh, H Tsumoto, T Kakizawa, K Mino, K Fukuhara, ... Angewandte Chemie International Edition 52 (33), 2013 | 102 | 2013 |
| Development of target protein-selective degradation inducer for protein knockdown Y Itoh, M Ishikawa, R Kitaguchi, S Sato, M Naito, Y Hashimoto Bioorganic & medicinal chemistry 19 (10), 3229-3241, 2011 | 94 | 2011 |
| Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity T Suzuki, H Ozasa, Y Itoh, P Zhan, H Sawada, K Mino, L Walport, ... Journal of medicinal chemistry 56 (18), 7222-7231, 2013 | 92 | 2013 |
| Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist Y Itoh, M Ishikawa, R Kitaguchi, K Okuhira, M Naito, Y Hashimoto Bioorganic & medicinal chemistry letters 22 (13), 4453-4457, 2012 | 91 | 2012 |
| Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8‐selective inhibitors T Suzuki, N Muto, M Bando, Y Itoh, A Masaki, M Ri, Y Ota, H Nakagawa, ... ChemMedChem 9 (3), 657-664, 2014 | 77 | 2014 |
| Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site,“selectivity pocket” and NAD+-binding site P Mellini, Y Itoh, H Tsumoto, Y Li, M Suzuki, N Tokuda, T Kakizawa, ... Chemical science 8 (9), 6400-6408, 2017 | 65 | 2017 |
