| Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies Y Yao, P Chen, J Diao, G Cheng, L Deng, JL Anglin, BVV Prasad, Y Song Journal of the American Chemical Society 133 (42), 16746-16749, 2011 | 181 | 2011 |
| DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia RE Rau, BA Rodriguez, M Luo, M Jeong, A Rosen, JH Rogers, ... Blood, The Journal of the American Society of Hematology 128 (7), 971-981, 2016 | 130 | 2016 |
| Synthesis and structure–activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L JL Anglin, L Deng, Y Yao, G Cai, Z Liu, H Jiang, G Cheng, P Chen, ... Journal of medicinal chemistry 55 (18), 8066-8074, 2012 | 109 | 2012 |
| Crystallographic investigation and selective inhibition of mutant isocitrate dehydrogenase B Zheng, Y Yao, Z Liu, L Deng, JL Anglin, H Jiang, BVV Prasad, Y Song ACS medicinal chemistry letters 4 (6), 542-546, 2013 | 108 | 2013 |
| Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer L Zhang, L Deng, F Chen, Y Yao, B Wu, L Wei, Q Mo, Y Song Oncotarget 5 (21), 10665, 2014 | 91 | 2014 |
| 3-(Piperidin-4-ylmethoxy) pyridine containing compounds are potent inhibitors of lysine specific demethylase 1 F Wu, C Zhou, Y Yao, L Wei, Z Feng, L Deng, Y Song Journal of medicinal chemistry 59 (1), 253-263, 2016 | 89 | 2016 |
| DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy W Liu, L Deng, Y Song, M Redell PLoS One 9 (5), e98270, 2014 | 86 | 2014 |
| Coordination Chemistry Based Approach to Lipophilic Inhibitors of 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase L Deng, S Sundriyal, V Rubio, Z Shi, Y Song Journal of medicinal chemistry 52 (21), 6539-6542, 2009 | 86 | 2009 |
| Inhibition of 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic Studies L Deng, J Diao, P Chen, V Pujari, Y Yao, G Cheng, DC Crick, BVV Prasad, ... Journal of medicinal chemistry 54 (13), 4721-4734, 2011 | 84 | 2011 |
| Stereocontrolled and convergent total synthesis of amphidinolide T3 LS Deng, XP Huang, G Zhao The Journal of Organic Chemistry 71 (12), 4625-4635, 2006 | 80 | 2006 |
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure–activity relationship, and selective antitumor activity Z Liu, Y Yao, M Kogiso, B Zheng, L Deng, JJ Qiu, S Dong, H Lv, JM Gallo, ... Journal of Medicinal Chemistry 57 (20), 8307-8318, 2014 | 73 | 2014 |
| Antimalarial and structural studies of pyridine-containing inhibitors of 1-deoxyxylulose-5-phosphate reductoisomerase J Xue, J Diao, G Cai, L Deng, B Zheng, Y Yao, Y Song ACS medicinal chemistry letters 4 (2), 278-282, 2013 | 66 | 2013 |
| Structural basis of substrate specificity and protease inhibition in Norwalk virus Z Muhaxhiri, L Deng, S Shanker, B Sankaran, MK Estes, T Palzkill, ... Journal of virology 87 (8), 4281-4292, 2013 | 61 | 2013 |
| Structures of 1-deoxy-D-xylulose-5-phosphate reductoisomerase/lipophilic phosphonate complexes L Deng, K Endo, M Kato, G Cheng, S Yajima, Y Song ACS medicinal chemistry letters 2 (2), 165-170, 2011 | 59 | 2011 |
| 2-Substituted 4, 5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases P Chen, LB Horton, RL Mikulski, L Deng, S Sundriyal, T Palzkill, Y Song Bioorganic & medicinal chemistry letters 22 (19), 6229-6232, 2012 | 46 | 2012 |
| Antiviral targets of human noroviruses BVV Prasad, S Shanker, Z Muhaxhiri, L Deng, JM Choi, MK Estes, Y Song, ... Current opinion in virology 18, 117-125, 2016 | 43 | 2016 |
| Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L L Deng, L Zhang, Y Yao, C Wang, MS Redell, S Dong, Y Song MedChemComm 4 (5), 822-826, 2013 | 42 | 2013 |
| Selective inhibitors of histone methyltransferase dot1l Y Song, P Chen, D Jiasheng, G Cheng, D Lisheng, JL Anglin, ... US Patent App. 14/015,913, 2014 | 23 | 2014 |
| A stereoselective total synthesis of 7, 8-O-isopropylidene iriomoteolide-3a Y Zhang, L Deng, G Zhao Organic & Biomolecular Chemistry 9 (12), 4518-4526, 2011 | 22 | 2011 |
| Synthesis, activity and structure–activity relationship of noroviral protease inhibitors L Deng, Z Muhaxhiri, MK Estes, T Palzkill, BVV Prasad, Y Song MedChemComm 4 (10), 1354-1359, 2013 | 21 | 2013 |
