| Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration KL Paumier, KC Luk, FP Manfredsson, NM Kanaan, JW Lipton, TJ Collier, ... Neurobiology of disease 82, 185-199, 2015 | 403 | 2015 |
| The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease OS Gorbatyuk, S Li, LF Sullivan, W Chen, G Kondrikova, FP Manfredsson, ... Proceedings of the National Academy of Sciences 105 (2), 763-768, 2008 | 373 | 2008 |
| The contribution of alpha synuclein to neuronal survival and function–Implications for Parkinson's disease MJ Benskey, RG Perez, FP Manfredsson Journal of neurochemistry 137 (3), 331-359, 2016 | 267 | 2016 |
| In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration OS Gorbatyuk, S Li, K Nash, M Gorbatyuk, AS Lewin, LF Sullivan, ... Molecular Therapy 18 (8), 1450-1457, 2010 | 237 | 2010 |
| Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology FP Manfredsson, KC Luk, MJ Benskey, A Gezer, J Garcia, NC Kuhn, ... Neurobiology of disease 112, 106-118, 2018 | 170 | 2018 |
| Deficiency in BDNF/TrkB neurotrophic activity stimulates δ-secretase by upregulating C/EBPβ in Alzheimer’s disease ZH Wang, J Xiang, X Liu, SP Yu, FP Manfredsson, IM Sandoval, S Wu, ... Cell reports 28 (3), 655-669. e5, 2019 | 164 | 2019 |
| Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease Z Zhang, SS Kang, X Liu, EH Ahn, Z Zhang, L He, PM Iuvone, DM Duong, ... Nature structural & molecular biology 24 (8), 632-642, 2017 | 163 | 2017 |
| Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders RJ Mandel, FP Manfredsson, KD Foust, A Rising, S Reimsnider, K Nash, ... Molecular Therapy 13 (3), 463-483, 2006 | 159 | 2006 |
| Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat S Reimsnider, FP Manfredsson, N Muzyczka, RJ Mandel Molecular Therapy 15 (8), 1504-1511, 2007 | 129 | 2007 |
| A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures TM Grabinski, A Kneynsberg, FP Manfredsson, NM Kanaan PloS one 10 (3), e0120120, 2015 | 128 | 2015 |
| Is alpha-synuclein loss-of-function a contributor to parkinsonian pathology? Evidence from non-human primates TJ Collier, DE Redmond Jr, K Steece-Collier, JW Lipton, FP Manfredsson Frontiers in neuroscience 10, 12, 2016 | 118 | 2016 |
| Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity FP Manfredsson, N Tumer, B Erdos, T Landa, CS Broxson, LF Sullivan, ... Molecular Therapy 17 (6), 980-991, 2009 | 118 | 2009 |
| C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease ZH Wang, K Gong, X Liu, Z Zhang, X Sun, ZZ Wei, SP Yu, ... Nature communications 9 (1), 1784, 2018 | 113 | 2018 |
| TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease SS Kang, Z Zhang, X Liu, FP Manfredsson, MJ Benskey, X Cao, J Xu, ... Proceedings of the National Academy of Sciences 114 (40), 10773-10778, 2017 | 108 | 2017 |
| Loss of functional alpha-synuclein: a toxic event in Parkinson's disease? NM Kanaan, FP Manfredsson Journal of Parkinson's disease 2 (4), 249-267, 2012 | 102 | 2012 |
| AAV9: a potential blood-brain barrier buster FP Manfredsson, AC Rising, RJ Mandel Molecular Therapy 17 (3), 403-405, 2009 | 101 | 2009 |
| Silencing alpha synuclein in mature nigral neurons results in rapid neuroinflammation and subsequent toxicity MJ Benskey, RC Sellnow, IM Sandoval, CE Sortwell, JW Lipton, ... Frontiers in molecular neuroscience 11, 36, 2018 | 97 | 2018 |
| Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system SE Gombash, FP Manfredsson, CJ Kemp, NC Kuhn, SM Fleming, ... PloS one 8 (11), e81426, 2013 | 95 | 2013 |
| High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis A Sturchio, AK Dwivedi, CB Young, T Malm, L Marsili, JS Sharma, ... EClinicalMedicine 38, 2021 | 93 | 2021 |
| α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease SS Kang, EH Ahn, Z Zhang, X Liu, FP Manfredsson, IM Sandoval, ... The EMBO journal 37 (12), e98878, 2018 | 87 | 2018 |
