| Activation of STING-dependent innate immune signaling by S-phase-specific DNA damage in breast cancer EE Parkes, SM Walker, LE Taggart, N McCabe, LA Knight, R Wilkinson, ... Journal of the National Cancer Institute 109 (1), djw199, 2017 | 427 | 2017 |
| Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation M Gatei, K Sloper, C Sorensen, R Syljuäsen, J Falck, K Hobson, ... Journal of Biological Chemistry 278 (17), 14806-14811, 2003 | 426 | 2003 |
| Single-stranded DNA-binding protein hSSB1 is critical for genomic stability DJ Richard, E Bolderson, L Cubeddu, RIM Wadsworth, K Savage, ... Nature 453 (7195), 677-681, 2008 | 283 | 2008 |
| Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells H Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, ... Leukemia 29 (5), 1092-1103, 2015 | 229 | 2015 |
| Use of the γ-H2AX assay to investigate DNA repair dynamics following multiple radiation exposures LG Mariotti, G Pirovano, KI Savage, M Ghita, A Ottolenghi, KM Prise, ... PloS one 8 (11), e79541, 2013 | 226 | 2013 |
| BRCA 1, a ‘complex’protein involved in the maintenance of genomic stability KI Savage, DP Harkin The FEBS journal 282 (4), 630-646, 2015 | 220 | 2015 |
| BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage M Fabbro, K Savage, K Hobson, AJ Deans, SN Powell, GA McArthur, ... Journal of Biological Chemistry 279 (30), 31251-31258, 2004 | 214 | 2004 |
| Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability KI Savage, JJ Gorski, EM Barros, GW Irwin, L Manti, AJ Powell, ... Molecular cell 54 (3), 445-459, 2014 | 201 | 2014 |
| BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability KI Savage, KB Matchett, EM Barros, KM Cooper, GW Irwin, JJ Gorski, ... Cancer research 74 (10), 2773-2784, 2014 | 153 | 2014 |
| Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes H Dolatshad, A Pellagatti, FG Liberante, M Llorian, E Repapi, V Steeples, ... Leukemia 30 (12), 2322-2331, 2016 | 139 | 2016 |
| BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription MT Harte, GJ O'Brien, NM Ryan, JJ Gorski, KI Savage, NT Crawford, ... Cancer research 70 (6), 2538-2547, 2010 | 136 | 2010 |
| The nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin A Kalousi, AS Hoffbeck, PN Selemenakis, J Pinder, KI Savage, ... Cell reports 11 (1), 149-163, 2015 | 103 | 2015 |
| hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex DJ Richard, K Savage, E Bolderson, L Cubeddu, S So, M Ghita, DJ Chen, ... Nucleic acids research 39 (5), 1692-1702, 2011 | 98 | 2011 |
| The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export J Vohhodina, EM Barros, AL Savage, FG Liberante, L Manti, P Bankhead, ... Nucleic acids research 45 (22), 12816-12833, 2017 | 97 | 2017 |
| Mechanistic rationale to target PTEN-deficient tumor cells with inhibitors of the DNA damage response kinase ATM N McCabe, C Hanna, SM Walker, D Gonda, J Li, K Wikstrom, KI Savage, ... Cancer research 75 (11), 2159-2165, 2015 | 77 | 2015 |
| Krüppel-associated box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin E Bolderson, KI Savage, R Mahen, V Pisupati, ME Graham, DJ Richard, ... Journal of Biological Chemistry 287 (33), 28122-28131, 2012 | 68 | 2012 |
| NF-κB is a critical mediator of BRCA1-induced chemoresistance MT Harte, JJ Gorski, KI Savage, JW Purcell, EM Barros, PM Burn, ... Oncogene 33 (6), 713-723, 2014 | 67 | 2014 |
| Robustness of differential gene expression analysis of RNA-seq A Stupnikov, CE McInerney, KI Savage, SA McIntosh, F Emmert-Streib, ... Computational and structural biotechnology journal 19, 3470-3481, 2021 | 57 | 2021 |
| Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis JJ Gorski, KI Savage, JM Mulligan, SS McDade, JK Blayney, Z Ge, ... Nucleic acids research 39 (22), 9536-9548, 2011 | 55 | 2011 |
| PARP inhibition induces BAX/BAK‐independent synthetic lethality of BRCA1‐deficient non‐small cell lung cancer I Paul, KI Savage, JK Blayney, E Lamers, K Gately, K Kerr, M Sheaff, ... The Journal of pathology 224 (4), 564-574, 2011 | 46 | 2011 |
