Photochemical intermolecular dearomative cycloaddition of bicyclic azaarenes with alkenes J Ma, S Chen, P Bellotti, R Guo, F Schäfer, A Heusler, X Zhang, ... Science 371 (6536), 1338-1345, 2021 | 137 | 2021 |
FAD-dependent enzyme-catalysed intermolecular [4+ 2] cycloaddition in natural product biosynthesis L Gao, C Su, X Du, R Wang, S Chen, Y Zhou, C Liu, X Liu, R Tian, ... Nature Chemistry 12 (7), 620-628, 2020 | 129 | 2020 |
Non-C2-Symmetric Chiral-at-Ruthenium Catalyst for Highly Efficient Enantioselective Intramolecular C(sp3)–H Amidation Z Zhou, S Chen, Y Hong, E Winterling, Y Tan, M Hemming, K Harms, ... Journal of the American Chemical Society 141 (48), 19048-19057, 2019 | 109 | 2019 |
Proton donor acidity controls selectivity in nonaromatic nitrogen heterocycle synthesis S Duttwyler, S Chen, MK Takase, KB Wiberg, RG Bergman, JA Ellman Science 339 (6120), 678-682, 2013 | 84 | 2013 |
Catalytic Enantioselective Intramolecular C(sp3)−H Amination of 2‐Azidoacetamides Z Zhou, S Chen, J Qin, X Nie, X Zheng, K Harms, R Riedel, KN Houk, ... Angewandte Chemie International Edition 58 (4), 1088-1093, 2019 | 83 | 2019 |
Atroposelective synthesis of axially chiral N‐Arylpyrroles by chiral‐at‐rhodium catalysis CX Ye, S Chen, F Han, X Xie, S Ivlev, KN Houk, E Meggers Angewandte Chemie 132 (32), 13654-13658, 2020 | 77 | 2020 |
Catalytic α-deracemization of ketones enabled by photoredox deprotonation and enantioselective protonation C Zhang, AZ Gao, X Nie, CX Ye, SI Ivlev, S Chen, E Meggers Journal of the American Chemical Society 143 (33), 13393-13400, 2021 | 76 | 2021 |
Catalytic asymmetric Staudinger–aza-Wittig reaction for the synthesis of heterocyclic amines L Cai, K Zhang, S Chen, RJ Lepage, KN Houk, EH Krenske, O Kwon Journal of the American Chemical Society 141 (24), 9537-9542, 2019 | 75 | 2019 |
Open-shell fluorination of alkyl bromides: unexpected selectivity in a silyl radical-mediated chain process GH Lovett, S Chen, XS Xue, KN Houk, DWC MacMillan Journal of the American Chemical Society 141 (51), 20031-20036, 2019 | 74 | 2019 |
Regio‐and Stereoselective 1, 2‐Dihydropyridine Alkylation/Addition Sequence for the Synthesis of Piperidines with Quaternary Centers S Duttwyler, S Chen, C Lu, BQ Mercado, RG Bergman, JA Ellman Angewandte Chemie 126 (15), 3958-3961, 2014 | 63 | 2014 |
Origins of Enantioselectivity in Asymmetric Radical Additions to Octahedral Chiral-at-Rhodium Enolates: A Computational Study S Chen, X Huang, E Meggers, KN Houk Journal of the American Chemical Society 139 (49), 17902-17907, 2017 | 60 | 2017 |
Highly diastereoselective functionalization of piperidines by photoredox-catalyzed α-amino C–H arylation and epimerization MM Walker, B Koronkiewicz, S Chen, KN Houk, JM Mayer, JA Ellman Journal of the American Chemical Society 142 (18), 8194-8202, 2020 | 58 | 2020 |
Stereocontrolled 1, 3-nitrogen migration to access chiral α-amino acids CX Ye, X Shen, S Chen, E Meggers Nature chemistry 14 (5), 566-573, 2022 | 52 | 2022 |
Facile access to fused 2D/3D rings via intermolecular cascade dearomative [2+ 2] cycloaddition/rearrangement reactions of quinolines with alkenes J Ma, S Chen, P Bellotti, T Wagener, C Daniliuc, KN Houk, F Glorius Nature Catalysis 5 (5), 405-413, 2022 | 50 | 2022 |
Intercepting fleeting cyclic allenes with asymmetric nickel catalysis MM Yamano, AV Kelleghan, Q Shao, M Giroud, BJ Simmons, B Li, ... Nature 586 (7828), 242-247, 2020 | 47 | 2020 |
Photochemical dearomative cycloadditions of quinolines and alkenes: scope and mechanism studies R Guo, S Adak, P Bellotti, X Gao, WW Smith, SN Le, J Ma, KN Houk, ... Journal of the American Chemical Society 144 (38), 17680-17691, 2022 | 43 | 2022 |
Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (−)-Bilobalide RM Demoret, MA Baker, M Ohtawa, S Chen, CC Lam, S Khom, M Roberto, ... Journal of the American Chemical Society 142 (43), 18599-18618, 2020 | 43 | 2020 |
Efficient Z-Selective Olefin-Acrylamide Cross-Metathesis Enabled by Sterically Demanding Cyclometalated Ruthenium Catalysts Y Xu, JJ Wong, AE Samkian, JH Ko, S Chen, KN Houk, RH Grubbs Journal of the American Chemical Society 142 (50), 20987-20993, 2020 | 40 | 2020 |
Facile Rh (III)-catalyzed synthesis of fluorinated pyridines S Chen, RG Bergman, JA Ellman Organic letters 17 (11), 2567-2569, 2015 | 39 | 2015 |
Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists BJ Huffman, S Chen, JL Schwarz, RE Plata, EN Chin, LL Lairson, ... Nature Chemistry 12 (3), 310-317, 2020 | 36 | 2020 |