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Christopher J. Smedley
Christopher J. Smedley
在 monash.edu 的电子邮件经过验证
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The growing applications of SuFEx click chemistry
AS Barrow, CJ Smedley, Q Zheng, S Li, J Dong, JE Moses
Chemical Society Reviews 48 (17), 4731-4758, 2019
3782019
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Q Zheng, JL Woehl, S Kitamura, D Santos-Martins, CJ Smedley, G Li, ...
Proceedings of the National Academy of Sciences 116 (38), 18808-18814, 2019
1572019
Diversity oriented clicking (DOC): divergent synthesis of SuFExable pharmacophores from 2‐substituted‐alkynyl‐1‐sulfonyl fluoride (SASF) hubs
CJ Smedley, G Li, AS Barrow, TL Gialelis, MC Giel, A Ottonello, Y Cheng, ...
Angewandte Chemie 132 (30), 12560-12569, 2020
942020
Metal‐free synthesis of functional 1‐substituted‐1, 2, 3‐triazoles from ethenesulfonyl fluoride and organic azides
MC Giel, CJ Smedley, ERR Mackie, T Guo, J Dong, TP Soares da Costa, ...
Angewandte Chemie 132 (3), 1197-1202, 2020
792020
1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry
CJ Smedley, MC Giel, A Molino, AS Barrow, DJD Wilson, JE Moses
Chemical Communications 54 (47), 6020-6023, 2018
762018
Accelerated SuFEx click chemistry for modular synthesis
CJ Smedley, JA Homer, TL Gialelis, AS Barrow, RA Koelln, JE Moses
Angewandte Chemie 134 (4), e202112375, 2022
722022
Bifluoride ion mediated SuFEx trifluoromethylation of sulfonyl fluorides and iminosulfur oxydifluorides
CJ Smedley, Q Zheng, B Gao, S Li, A Molino, HM Duivenvoorden, ...
Angewandte Chemie International Edition 58 (14), 4552-4556, 2019
722019
Sulfur–Fluoride Exchange (SuFEx)‐Mediated Synthesis of Sterically Hindered and Electron‐Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates
CJ Smedley, AS Barrow, C Spiteri, MC Giel, P Sharma, JE Moses
Chemistry–A European Journal 23 (42), 9990-9995, 2017
422017
Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents
J Adams, EC Anderson, EE Blackham, YWR Chiu, T Clarke, N Eccles, ...
ACS Medicinal Chemistry Letters 5 (11), 1207-1212, 2014
322014
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
Y Cheng, G Li, CJ Smedley, MC Giel, S Kitamura, JL Woehl, G Bianco, ...
Proceedings of the National Academy of Sciences 119 (37), e2208540119, 2022
172022
Phosphorus fluoride exchange: Multidimensional catalytic click chemistry from phosphorus connective hubs
S Sun, JA Homer, CJ Smedley, QQ Cheng, KB Sharpless, JE Moses
Chem 9 (8), 2128-2143, 2023
162023
Sustainable syntheses of (−)-jerantinines A & E and structural characterisation of the jerantinine-tubulin complex at the colchicine binding site
CJ Smedley, PA Stanley, ME Qazzaz, AE Prota, N Olieric, H Collins, ...
Scientific reports 8 (1), 10617, 2018
142018
Ethene‐1, 1‐disulfonyl Difluoride (EDSF) for SuFEx Click Chemistry: Synthesis of SuFExable 1, 1‐Bissulfonylfluoride Substituted Cyclobutene Hubs
CJ Smedley, MC Giel, T Fallon, JE Moses
Angewandte Chemie International Edition 62 (30), e202303916, 2023
82023
A diversity oriented clicking strategy: the stereoselective synthesis of highly-functionalised olefins from 2-substituted-alkynyl-1-sulfonyl fluorides
CJ Smedley
Chemical Communications 58 (80), 11316-11319, 2022
72022
Aminium cation-radical catalysed selective hydration of (E)-aryl enynes
MC Giel, AS Barrow, CJ Smedley, W Lewis, JE Moses
Chemical Communications 57 (57), 6991-6994, 2021
42021
Sulfur fluoride exchange (SuFEx)
MC Giel, CJ Smedley, JE Moses
42021
Phosphorus (V) fluoride exchange (PFEx): multidimensional click chemistry from phosphorus (V) connective hubs
S Sun, CJ Smedley, JA Homer, QQ Cheng, KB Sharpless, JE Moses
32022
“Sleeping beauty” phenomenon: SuFEx-enabled discovery of selective covalent inhibitors of human neutrophil elastase
Q Zheng, JL Woehl, S Kitamura, D Santos-Martins, CJ Smedley, G Li, ...
22019
Inhibition of mitochondrial metabolism by (−)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells
TL Gialelis, Z Wang, JA Homer, WH Yang, T Chung, Q Hu, CJ Smedley, ...
RSC Medicinal Chemistry 14 (4), 710-714, 2023
12023
Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors
Y Cheng, G Li, CJ Smedley, MC Giel, S Kitamura, JL Woehl, G Bianco, ...
2022
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