Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities S Heinz, C Benner, N Spann, E Bertolino, YC Lin, P Laslo, JX Cheng, ... Molecular Cell 38 (4), 576-589, 2010 | 11521 | 2010 |
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate YC Lin, S Jhunjhunwala, C Benner, S Heinz, E Welinder, R Mansson, ... Nature Immunology 11 (7), 635, 2010 | 542 | 2010 |
Global changes in the nuclear positioning of genes and intra-and interdomain genomic interactions that orchestrate B cell fate YC Lin, C Benner, R Mansson, S Heinz, K Miyazaki, M Miyazaki, ... Nature Immunology 13 (12), 1196, 2012 | 299 | 2012 |
ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation EL Stone, M Pepper, CD Katayama, YM Kerdiles, CY Lai, E Emslie, ... Immunity 42 (2), 239-251, 2015 | 254 | 2015 |
CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells SC Degner, J Verma-Gaur, TP Wong, C Bossen, GM Iverson, ... Proceedings of the National Academy of Sciences 108 (23), 9566-9571, 2011 | 243 | 2011 |
Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors EM Mercer, YC Lin, C Benner, S Jhunjhunwala, J Dutkowski, M Flores, ... Immunity 35 (3), 413-425, 2011 | 153 | 2011 |
The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells M Miyazaki, RR Rivera, K Miyazaki, YC Lin, Y Agata, C Murre Nature Immunology 12 (10), 992, 2011 | 143 | 2011 |
Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate R Mansson, E Welinder, J Åhsberg, YC Lin, C Benner, CK Glass, ... Proceedings of the National Academy of Sciences 109 (51), 21028-21033, 2012 | 122 | 2012 |
TFIIH XPB mutants suggest a unified bacterial-like mechanism for promoter opening but not escape YC Lin, WS Choi, JD Gralla Nature structural & molecular biology 12 (7), 603-607, 2005 | 102 | 2005 |
The E-Id protein axis specifies adaptive lymphoid cell identity and suppresses thymic innate lymphoid cell development M Miyazaki, K Miyazaki, K Chen, Y Jin, J Turner, AJ Moore, R Saito, ... Immunity 46 (5), 818-834. e4, 2017 | 86 | 2017 |
Active enhancer and chromatin accessibility landscapes chart the regulatory network of primary multiple myeloma Y Jin, K Chen, A De Paepe, E Hellqvist, AD Krstic, L Metang, ... Blood, The Journal of the American Society of Hematology 131 (19), 2138-2150, 2018 | 78 | 2018 |
Factors and networks that underpin early hematopoiesis EM Mercer, YC Lin, C Murre Seminars in Immunology 23 (5), 317-325, 2011 | 60 | 2011 |
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation TD Holmes, RV Pandey, EY Helm, H Schlums, H Han, TM Campbell, ... Science immunology 6 (57), eabc9801, 2021 | 57 | 2021 |
Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts P Noel, S Hussein, S Ng, CE Antal, W Lin, E Rodela, P Delgado, ... Oncogenesis 9 (11), 100, 2020 | 48 | 2020 |
The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells K Miyazaki, H Watanabe, G Yoshikawa, K Chen, R Hidaka, Y Aitani, ... Science Immunology 5 (51), eabb1455, 2020 | 42 | 2020 |
Transcriptional repression of IFN regulatory factor 7 by MYC is critical for type I IFN production in human plasmacytoid dendritic cells TW Kim, S Hong, Y Lin, E Murat, HM Joo, T Kim, V Pascual, YJ Liu The Journal of Immunology 197 (8), 3348-3359, 2016 | 38 | 2016 |
Stimulation of the XPB ATP-dependent helicase by the beta subunit of TFIIE YC Lin, JD Gralla Nucleic Acids Research 33 (9), 3072-3081, 2005 | 27 | 2005 |
Plasma cell fate is orchestrated by elaborate changes in genome compartmentalization and inter-chromosomal hubs A Bortnick, Z He, M Aubrey, V Chandra, M Denholtz, K Chen, YC Lin, ... Cell reports 31 (1), 2020 | 25 | 2020 |
Chromatin accessibility identifies regulatory elements predictive of gene expression and disease outcome in multiple myeloma BG Barwick, VA Gupta, SM Matulis, JC Patton, DR Powell, Y Gu, DL Jaye, ... Clinical Cancer Research 27 (11), 3178-3189, 2021 | 16 | 2021 |
CTCF expression and dynamic motif accessibility modulates epithelial–mesenchymal gene expression KS Johnson, S Hussein, P Chakraborty, A Muruganantham, S Mikhail, ... Cancers 14 (1), 209, 2022 | 15 | 2022 |