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| Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity YJ Zhang, YF Xu, C Cook, TF Gendron, P Roettges, CD Link, WL Lin, ... Proceedings of the National Academy of Sciences 106 (18), 7607-7612, 2009 | 674 | 2009 |
| Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS TF Gendron, KF Bieniek, YJ Zhang, K Jansen-West, PEA Ash, T Caulfield, ... Acta neuropathologica 126, 829-844, 2013 | 639 | 2013 |
| Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice YF Xu, TF Gendron, YJ Zhang, WL Lin, S D'Alton, H Sheng, MC Casey, ... Journal of Neuroscience 30 (32), 10851-10859, 2010 | 605 | 2010 |
| Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis NJ Rutherford, YJ Zhang, M Baker, JM Gass, NCA Finch, YF Xu, ... PLoS genetics 4 (9), e1000193, 2008 | 533 | 2008 |
| TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD CC Chou, YI Zhang, ME Umoh, SW Vaughan, I Lorenzini, F Liu, ... Nature neuroscience 21 (2), 228-239, 2018 | 512 | 2018 |
| C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits J Chew, TF Gendron, M Prudencio, H Sasaguri, YJ Zhang, ... Science 348 (6239), 1151-1154, 2015 | 464 | 2015 |
| Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43 YJ Zhang, Y Xu, CA Dickey, E Buratti, F Baralle, R Bailey, ... Journal of Neuroscience 27 (39), 10530-10534, 2007 | 434 | 2007 |
| Aggregation-prone c9FTD/ALS poly (GA) RAN-translated proteins cause neurotoxicity by inducing ER stress YJ Zhang, K Jansen-West, YF Xu, TF Gendron, KF Bieniek, WL Lin, ... Acta neuropathologica 128, 505-524, 2014 | 393 | 2014 |
| Discovery of a biomarker and lead small molecules to target r (GGGGCC)-associated defects in c9FTD/ALS Z Su, Y Zhang, TF Gendron, PO Bauer, J Chew, WY Yang, E Fostvedt, ... Neuron 83 (5), 1043-1050, 2014 | 381 | 2014 |
| C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins YJ Zhang, TF Gendron, JC Grima, H Sasaguri, K Jansen-West, YF Xu, ... Nature neuroscience 19 (5), 668-677, 2016 | 327 | 2016 |
| Human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice OM Peters, GT Cabrera, H Tran, TF Gendron, JE McKeon, J Metterville, ... Neuron 88 (5), 902-909, 2015 | 289 | 2015 |
| Neurotoxic effects of TDP-43 overexpression in C. elegans PEA Ash, YJ Zhang, CM Roberts, T Saldi, H Hutter, E Buratti, L Petrucelli, ... Human molecular genetics 19 (16), 3206-3218, 2010 | 285 | 2010 |
| Phosphorylation of tau antagonizes apoptosis by stabilizing β-catenin, a mechanism involved in Alzheimer's neurodegeneration HL Li, HH Wang, SJ Liu, YQ Deng, YJ Zhang, Q Tian, XC Wang, XQ Chen, ... Proceedings of the National Academy of Sciences 104 (9), 3591-3596, 2007 | 283 | 2007 |
| Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis YJ Zhang, TF Gendron, MTW Ebbert, AD O’Raw, M Yue, K Jansen-West, ... Nature medicine 24 (8), 1136-1142, 2018 | 280 | 2018 |
| Akt and CHIP coregulate tau degradation through coordinated interactions CA Dickey, J Koren, YJ Zhang, Y Xu, UK Jinwal, MJ Birnbaum, B Monks, ... Proceedings of the National Academy of Sciences 105 (9), 3622-3627, 2008 | 243 | 2008 |
| Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis TF Gendron, J Chew, JN Stankowski, LR Hayes, YJ Zhang, M Prudencio, ... Science translational medicine 9 (383), eaai7866, 2017 | 233 | 2017 |
| Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity YJ Zhang, L Guo, PK Gonzales, TF Gendron, Y Wu, K Jansen-West, ... Science 363 (6428), eaav2606, 2019 | 218 | 2019 |
| CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity HS Ko, R Bailey, WW Smith, Z Liu, JH Shin, YI Lee, YJ Zhang, H Jiang, ... Proceedings of the National Academy of Sciences 106 (8), 2897-2902, 2009 | 208 | 2009 |
| Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice YF Xu, YJ Zhang, WL Lin, X Cao, C Stetler, DW Dickson, J Lewis, ... Molecular neurodegeneration 6, 1-14, 2011 | 206 | 2011 |
