Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis K Matsuoka, T Tamura, D Tsuji, Y Dohzono, K Kitakaze, K Ohno, S Saito, ... Molecular Therapy 19 (6), 1017-1024, 2011 | 87 | 2011 |
Chemical Synthesis of Biologically Active Monoglycosylated GM2‐Activator Protein Analogue Using N‐Sulfanylethylanilide Peptide K Sato, A Shigenaga, K Kitakaze, K Sakamoto, D Tsuji, K Itoh, A Otaka Angewandte Chemie International Edition 52 (30), 7855-7859, 2013 | 66 | 2013 |
Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts Y Takenouchi, K Kitakaze, K Tsuboi, Y Okamoto Experimental cell research 391 (2), 112010, 2020 | 45 | 2020 |
Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease T Kodama, T Togawa, T Tsukimura, I Kawashima, K Matsuoka, K Kitakaze, ... PLoS One 6 (12), e29074, 2011 | 42 | 2011 |
Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model K Kitakaze, Y Mizutani, E Sugiyama, C Tasaki, D Tsuji, N Maita, ... The Journal of Clinical Investigation 126 (5), 1691-1703, 2016 | 41 | 2016 |
ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model K Kitakaze, M Oyadomari, J Zhang, Y Hamada, Y Takenouchi, K Tsuboi, ... Molecular Metabolism 54, 101338, 2021 | 32 | 2021 |
Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity K Kitakaze, S Taniuchi, E Kawano, Y Hamada, M Miyake, M Oyadomari, ... Elife 8, e43302, 2019 | 28 | 2019 |
The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate K Sato, K Kitakaze, T Nakamura, N Naruse, K Aihara, A Shigenaga, ... Chemical Communications 51 (49), 9946-9948, 2015 | 26 | 2015 |
Development of a chemical methodology for the preparation of peptide thioesters applicable to naturally occurring peptides using a sequential quadruple acyl transfer system Y Tsuda, A Shigenaga, K Tsuji, M Denda, K Sato, K Kitakaze, T Nakamura, ... ChemistryOpen 4 (4), 448, 2015 | 18 | 2015 |
Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines K Tsuboi, T Tai, R Yamashita, H Ali, T Watanabe, T Uyama, Y Okamoto, ... Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2021 | 13 | 2021 |
Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation Y Okamoto, K Kitakaze, Y Takenouchi, S Yamamoto, H Ishimaru, K Tsuboi Cellular Signalling 88, 110156, 2021 | 11 | 2021 |
Tailored Synthesis of 162‐Residue S‐Monoglycosylated GM2‐Activator Protein (GM2AP) Analogues that Allows Facile Access to a Protein Library T Nakamura, K Sato, N Naruse, K Kitakaze, T Inokuma, T Hirokawa, ... ChemBioChem 17 (20), 1986-1992, 2016 | 8 | 2016 |
Combined replacement effects of human modified β-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts K Kitakaze, C Tasaki, Y Tajima, T Hirokawa, D Tsuji, H Sakuraba, K Itoh Biochemistry and Biophysics Reports 7, 157–163, 2016 | 8 | 2016 |
Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner S Okamoto, K Miyano, K Kitakaze, H Kato, A Yamauchi, M Kajikawa, ... Biochemical and Biophysical Research Communications 587, 78-84, 2021 | 7 | 2021 |
Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7 K Kitakaze, K Tsuboi, M Tsuda, Y Takenouchi, H Ishimaru, Y Okamoto Journal of Lipid Research 62, 100141, 2021 | 6 | 2021 |
GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator K Kitakaze, H Ali, R Kimoto, Y Takenouchi, H Ishimaru, A Yamashita, ... Communications Biology 6 (1), 524, 2023 | 5 | 2023 |
Targeted deletion of ATF4 in β cells leads to the vulnerability and dedifferentiation during ER stress K Kitakaze, K Kurahashi, M Miyake, Y Hamada, M Oyadomari, ... Diabetes 67 (Supplement 1), 2018 | 5 | 2018 |
Sweat Protects against Contact Hypersensitivity: Transient Sweat Suppression Compromises Skin Barrier Function in Mice H Ishimaru, K Nakamoto, M Yamane, T Yamamoto, K Kitakaze, ... Journal of Investigative Dermatology, 2024 | 1 | 2024 |
Cyclic phosphatidic acid is produced by GDE7 in the ER lumen as a lysophospholipid mediator K Kitakaze, H Ali, R Kimoto, Y Takenouchi, H Ishimaru, A Yamashita, ... | 1 | 2022 |
GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression Y Okamoto, K Kitakaze, Y Takenouchi, R Matsui, D Koga, R Miyashima, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1871 (7), 119798, 2024 | | 2024 |