Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients SJ Howe, MR Mansour, K Schwarzwaelder, C Bartholomae, M Hubank, ... The Journal of clinical investigation 118 (9), 2008 | 1454 | 2008 |
Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. FJ Staal, M Roederer, LA Herzenberg, LA Herzenberg Proceedings of the National Academy of Sciences 87 (24), 9943-9947, 1990 | 1216 | 1990 |
Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes CJM Loomans, EJP de Koning, FJT Staal, MB Rookmaaker, C Verseyden, ... Diabetes 53 (1), 195-199, 2004 | 1154 | 2004 |
WNT signalling in the immune system: WNT is spreading its wings FJT Staal, TC Luis, MM Tiemessen Nature Reviews Immunology 8 (8), 581-593, 2008 | 681 | 2008 |
Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. M Roederer, FJ Staal, PA Raju, SW Ela, LA Herzenberg, LA Herzenberg Proceedings of the National Academy of Sciences 87 (12), 4884-4888, 1990 | 536 | 1990 |
Glutathione deficiency and human immunodeficiency virus infection. FJT Staal, SW Ela The Lancet 339 (8798), 909-912, 1992 | 531 | 1992 |
Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway. MT Anderson, FJ Staal, C Gitler, LA Herzenberg, LA Herzenberg Proceedings of the National Academy of Sciences 91 (24), 11527-11531, 1994 | 479 | 1994 |
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling WA Dik, K Pike-Overzet, F Weerkamp, D De Ridder, EFE De Haas, ... The Journal of experimental medicine 201 (11), 1715-1723, 2005 | 462 | 2005 |
WNT signalling and haematopoiesis: a WNT–WNT situation FJT Staal, HC Clevers Nature Reviews Immunology 5 (1), 21-30, 2005 | 448 | 2005 |
Wnt signals are transmitted through N‐terminally dephosphorylated β‐catenin FJT Staal, M van Noort, GJ Strous, HC Clevers EMBO reports, 2002 | 411 | 2002 |
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia I Homminga, R Pieters, AW Langerak, JJ de Rooi, A Stubbs, M Verstegen, ... Cancer cell 19 (4), 484-497, 2011 | 405 | 2011 |
A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes RC Padmos, MHJ Hillegers, EM Knijff, R Vonk, A Bouvy, FJT Staal, ... Archives of general psychiatry 65 (4), 395-407, 2008 | 400 | 2008 |
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion TC Luis, BAE Naber, PPC Roozen, MH Brugman, EFE de Haas, ... Cell stem cell 9 (4), 345-356, 2011 | 362 | 2011 |
An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates J Goveia, K Rohlenova, F Taverna, L Treps, LC Conradi, A Pircher, ... Cancer cell 37 (1), 21-36. e13, 2020 | 344 | 2020 |
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences C Baum, C Von Kalle, FJT Staal, Z Li, B Fehse, M Schmidt, F Weerkamp, ... Molecular Therapy 9 (1), 5-13, 2004 | 300 | 2004 |
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy A Deichmann, S Hacein-Bey-Abina, M Schmidt, A Garrigue, MH Brugman, ... The Journal of clinical investigation 117 (8), 2225-2232, 2007 | 298 | 2007 |
Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx. FJ Staal, MT Anderson, GE Staal, LA Herzenberg, C Gitler, ... Proceedings of the National Academy of Sciences 91 (9), 3619-3622, 1994 | 286 | 1994 |
Wnt signaling is required for thymocyte development and activates Tcf‐1 mediated transcription FJT Staal, J Meeldijk, P Moerer, P Jay, BCM van de Weerdt, S Vainio, ... European journal of immunology 31 (1), 285-293, 2001 | 273 | 2001 |
CD34+ CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells P Res, E Martinez-Caceres, A Cristina Jaleco, F Staal, E Noteboom, ... | 246 | 1996 |
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development TC Luis, M Ichii, MH Brugman, P Kincade, FJT Staal Leukemia 26 (3), 414-421, 2012 | 244 | 2012 |